The biology and medicine of calcium signalling.

abstract：:The gene encoding ovine 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) was cloned and characterized. This gene consists of five exons and is greater than 4 kb in length. It contains an open reading frame of 1215 bp, which encodes a protein of 404 amino acids with a predicted MW of 44 kDa. The deduced ovine...

journal_title：Molecular and cellular endocrinology

authors： Campbell LE,Yu M,Yang K

更新日期：1996-05-17 00:00:00

abstract：:Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to...

journal_title：Molecular and cellular endocrinology

authors： Purohit A,Woo LW,Potter BV

更新日期：2011-07-04 00:00:00

abstract：:A new analogue of recombinant human growth hormone (hGH), hGH des(1-6,14) was expressed in Escherichia coli, refolded and purified to homogeneity. The mutation decreased the hormone's ability to bind lactogenic and somatogenic receptors through its site 1, and almost completely abolished its ability to bind these rece...

journal_title：Molecular and cellular endocrinology

authors： Tchelet A,Vogel T,Helman D,Guy R,Neospouolus C,Goffin V,Djiane J,Gertler A

更新日期：1997-06-20 00:00:00

abstract：:Osteoblastic metastases are common in patients with advanced prostate cancer. The pathophysiology of the new bone formation at metastatic sites is not currently known, but it is hypothesized that growth factors secreted by the prostate may be involved. Unfortunately, most rodent models of prostate cancer with metastas...

journal_title：Molecular and cellular endocrinology

authors： LeRoy BE,Bahnson RR,Rosol TJ

更新日期：2002-11-29 00:00:00

abstract：:Menin is a protein product of a tumor suppressor gene MEN1, mutations of which are responsible for multiple endocrine neoplasia type 1, an autosomal dominant familial cancer syndrome. We isolated rat menin cDNA clones from a fetal rat brain cDNA library. We also determined the nucleotide sequence of the protein coding...

journal_title：Molecular and cellular endocrinology

authors： Maruyama K,Tsukada T,Hosono T,Ohkura N,Kishi M,Honda M,Nara-Ashizawa N,Nagasaki K,Yamaguchi K

更新日期：1999-10-25 00:00:00

abstract：:Adrenocortical tumors (ACTs) frequently cause steroid excess and present cell-cycle dysregulation. cAMP/PKA signaling is involved in steroid synthesis and play a role in cell-cycle regulation. We investigated, by cell synchronization in the different phases of the cell-cycle, the control of steroidogenesis and the con...

journal_title：Molecular and cellular endocrinology

authors： Rizk-Rabin M,Chaoui-Ibadioune S,Vaczlavik A,Ribes C,Polak M,Ragazzon B,Bertherat J

更新日期：2020-01-15 00:00:00

abstract：:It has been suggested that activation of mitochondrial respiration by thyroid hormone results in oxidative tissue injury secondary to increased reactive oxygen species production. In order to throw light on this subject, the effects of thyroid state on O2 consumption and H2O2 release by rat liver mitochondria were inv...

journal_title：Molecular and cellular endocrinology

authors： Venditti P,De Rosa R,Di Meo S

更新日期：2003-07-31 00:00:00

abstract：:Transthyretin (TTR) is a plasma thyroid hormone (TH) binder that emerged from an ancient hydroxyisourate hydrolase by gene duplication. To know how an ancient TTR had high affinity for THs, molecular and TH binding properties of lamprey TTRs were investigated. In adult serum, the lipoprotein LAL was a major T3 binder ...

journal_title：Molecular and cellular endocrinology

authors： Kasai K,Nishiyama N,Yamauchi K

更新日期：2018-10-15 00:00:00

abstract：:Recently, a defect in pertussis toxin-independent actions of epinephrine on pancreatic B-cells of fa/fa Zucker rats was reported (Cawthorn and Chan (1991) Mol. Cell. Endocrinol. 75, 197-204). We now report studies of islet alpha 2-adrenoceptor function of fa/fa rats. Insulin and cAMP production by islets of obese rats...

journal_title：Molecular and cellular endocrinology

authors： Chan CB,MacPhail RM

更新日期：1992-03-01 00:00:00

abstract：:The present study was aimed at characterizing the deficiency of the glucocorticoid-receptor system in the immature pituitary gland of neonatal rats. Under conditions of both constant protein and DNA concentrations, [3H]dexamethasone binding to nuclei was significantly lower in the immature, compared with the mature, g...

journal_title：Molecular and cellular endocrinology

authors： Sakly M,Koch B

更新日期：1982-09-01 00:00:00

abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

journal_title：Molecular and cellular endocrinology

authors： Lewy H,Ashkenazi IE,Naor Z

更新日期：2003-05-30 00:00:00

abstract：:In this study we have investigated the protein phosphorylation pattern in the membrane fraction prepared from bovine luteal cells. The phosphorylation reaction was carried out in vitro, under defined conditions, using either [gamma-32P]ATP or [gamma-35S]ATP as the phosphate donor. The results obtained show that [gamma...

journal_title：Molecular and cellular endocrinology

authors： Budnik LT,Mukhopadhyay AK

更新日期：1990-03-05 00:00:00

abstract：:The present experiment used cultured mouse cumulus cell-enclosed oocytes (CEOs) and denuded oocytes (DOs) to study the function of nitric oxide (NO) in mouse oocyte meiotic maturation. Either positive or negative actions of NO on meiotic maturation has been observed when CEOs or DOs were cultured for 24 h in a medium ...

journal_title：Molecular and cellular endocrinology

authors： Bu S,Xia G,Tao Y,Lei L,Zhou B

更新日期：2003-09-30 00:00:00

abstract：:To fully evaluate the advantages of a cryopreservation program a method needs to be established to express the additional patients pregnant from cryopreservation. The patient specific method considers cryopreservation as augmentation only among patients without a pregnancy from the fresh transfer, or from previously t...

journal_title：Molecular and cellular endocrinology

authors： Schnorr JA,Muasher SJ,Jones HW Jr

更新日期：2000-11-27 00:00:00

abstract：:Accumulating evidence suggests that the human follitropin receptor is unusually sensitive to mutation. Previous results (Mol. Cell. Endo. 166 (2000) 101) determined that scanning mutations in a.a. 12-14 and 22-30 neither bound follitropin nor were present on the cell surface, suggesting that these regions are involved...

journal_title：Molecular and cellular endocrinology

authors： Nechamen CA,Dias JA

更新日期：2003-03-28 00:00:00

abstract：:The mechanisms of cytokine-induced beta-cell death are poorly characterised. In rat insulin-producing RINm5F cells, the combination of interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha presently induced disruption of the mitochondrial membrane potential (Deltapsi(m)) as demonstrated by reduced JC-1 ...

journal_title：Molecular and cellular endocrinology

authors： Barbu A,Welsh N,Saldeen J

更新日期：2002-04-25 00:00:00

abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

journal_title：Molecular and cellular endocrinology

authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

更新日期：2012-10-15 00:00:00

abstract：:In human granulosa-lutein cells, high-density lipoproteins (HDL) can stimulate progesterone synthesis. The objective of the present study was to establish whether prostaglandins (PGs) participate in the steroidogenic response to HDL. Both HDL and apolipoprotein AI (ApoAI) stimulated concentration-dependent increases i...

journal_title：Molecular and cellular endocrinology

authors： Chandras C,Ragoobir J,Barrett GE,Bruckdorfer KR,Graham A,Abayasekara DR,Michael AE

更新日期：2004-07-30 00:00:00

abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

journal_title：Molecular and cellular endocrinology

authors： Thompson BR,Lobo S,Bernlohr DA

更新日期：2010-04-29 00:00:00

abstract：:Spermatogonial stem cells are quiescent, undergo self-renewal or differentiating divisions, thereby forming the cellular basis of spermatogenesis. This cellular development is orchestrated by follicle-stimulating hormone (FSH), through the production of Sertoli cell-derived factors, and by Leydig cell-released androge...

journal_title：Molecular and cellular endocrinology

authors： Crespo D,Assis LHC,Furmanek T,Bogerd J,Schulz RW

更新日期：2016-12-05 00:00:00

abstract：:The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR g...

journal_title：Molecular and cellular endocrinology

authors： Henrohn D,Le Grevés P,Nyberg F

更新日期：1997-12-12 00:00:00

abstract：:In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst(1)-sst(5)) and the variety of si...

journal_title：Molecular and cellular endocrinology

authors： Cervia D,Casini G,Bagnoli P

更新日期：2008-05-14 00:00:00

abstract：:Adult neurogenesis occurs in neural stem cell (NSC) niches where slow cycling stem cells give rise to faster cycling progenitors. In the adult mouse NSC niche thyroid hormone, T3, and its receptor TRα act as a neurogenic switch promoting progenitor cell cycle completion and neuronal differentiation. Little is known ab...

journal_title：Molecular and cellular endocrinology

authors： Préau L,Le Blay K,Saint Paul E,Morvan-Dubois G,Demeneix BA

更新日期：2016-01-15 00:00:00

abstract：:The interaction of indomethacin with the antilipolytic effect of prostaglandin E2 (PGE2) was investigated in rat adipocytes in order to reveal a possible role of endogenous PGs in adipose tissue. Adipocytes isolated from rats treated in vivo for 5 days with indomethacin were compared with non-treated control rats. The...

journal_title：Molecular and cellular endocrinology

authors： Richelsen B

更新日期：1988-07-01 00:00:00

abstract：:A comparative study of hGH and IL2 post-signaling effects, as examined by RNA expression (Nb29) and protein levels of the heat-shock protein hsp70, was performed in a hormone-dependent rat lymphoma cell line, Nb2-11C. Optimal doses of hGH or IL2 increased Nb29 expression in a dose-dependent manner. Addition of both mi...

journal_title：Molecular and cellular endocrinology

authors： Horn S,Cohen R,Gertler A

更新日期：1994-11-01 00:00:00

abstract：:Exposure of human decidual cells for 0.5 h to dibutyryl cAMP, isobutyl-methylxanthine (IBMX), cholera toxin or forskolin caused a dose-dependent inhibition of prolactin release with maximal inhibition by each agent of 50-60%. Dibutyryl cAMP (5 mM), IBMX (0.5 mM), and cholera toxin (10 micrograms/ml) also inhibited pro...

journal_title：Molecular and cellular endocrinology

authors： Handwerger S,Harman I,Costello A,Markoff E

更新日期：1987-03-01 00:00:00

abstract：:The crucial effects of androgens on the male skeleton are at least partly mediated via the androgen receptor (AR). In addition to hormone binding, the AR activity is regulated by post-translational modifications, including SUMOylation. SUMOylation is a reversible modification in which Small Ubiquitin-related MOdifier ...

journal_title：Molecular and cellular endocrinology

authors： Wu J,Movérare-Skrtic S,Zhang FP,Koskela A,Tuukkanen J,Palvimo JJ,Sipilä P,Poutanen M,Ohlsson C

更新日期：2019-01-05 00:00:00

abstract：:In order to study the distribution of LH (HCG) receptors on luteal cells ferritin was coupled to ovine LH with glutaraldehyde and purified by gel chromatography. The conjugate (FELH) competed with 125I-hCG for binding to isolated luteal membranes and stimulated a dose-dependent release of progesterone (P) from isolate...

journal_title：Molecular and cellular endocrinology

authors： Luborsky JL,Behrman HR

更新日期：1979-08-01 00:00:00

abstract：:In cultured human lymphocytes (IM-9) and in isolated rat adipocytes human growth hormone is substrate for a receptor-mediated degradation. When the cells are incubated with monoiodinated human growth hormone half of the radioactivity dissociating from the cells is in the form of [125I]monoiodotyrosine. Since IM-9 lymp...

journal_title：Molecular and cellular endocrinology

authors： Weyer B,Sonne O

更新日期：1985-06-01 00:00:00

abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

更新日期：2016-01-05 00:00:00