Link between steroidogenesis, the cell cycle, and PKA in adrenocortical tumor cells.

abstract：:The angiotensin II (AngII) type 1 (AT(1)) receptor is a seven-transmembrane G protein-coupled receptor, and is involved in regulating the physiological and pathological process of the cardiovascular system. Systemically and locally generated AngII has agonistic action on AT(1) receptor, but recent studies have demonst...

journal_title：Molecular and cellular endocrinology

authors： Akazawa H,Yasuda N,Komuro I

更新日期：2009-04-29 00:00:00

abstract：:Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes. In addition to its effects improving insulin sensitivity, FGF21 causes weight loss by increasing energy ...

journal_title：Molecular and cellular endocrinology

authors： Giralt M,Gavaldà-Navarro A,Villarroya F

更新日期：2015-12-15 00:00:00

abstract：:The effects of a GnRH antagonist analogue (N-acetyl-Ala1,D-p-Cl-Phe2,D-Trp3,6-GnRH, Ant.) and a GnRH antiserum (A/S) on the development of pituitary-testicular function were studied in immature (23/24-31/32-day-old) rats. In another experiment the Ant. treatment was combined with bromocriptine (BR)-induced hypoprolact...

journal_title：Molecular and cellular endocrinology

authors： Huhtaniemi IT,Stewart JM,Channabasavaiah K,Fraser HM,Clayton RN

更新日期：1984-02-01 00:00:00

abstract：:Adrenal binding protein 4 (Ad4BP) known also as steroidogenic factor 1 (SF-1) is a cell specific transcription factor regulating all steroidogenic P450 genes and is present exclusively in steroidogenic tissues. In this study, we examined whether Ad4BP expression is affected by oncogene-induced cell transformation. Usi...

journal_title：Molecular and cellular endocrinology

authors： Keren-Tal I,Dantes A,Plehn-Dujowich D,Amsterdam A

更新日期：1997-03-14 00:00:00

abstract：:The major ganglioside NeuAc alpha 2-->3Gal beta 1-->4Glc beta 1-->1Cer (GM3) present in cultured rat granulosa cells was examined for potential function in the expression of luteinizing hormone (LH) receptor on the cell surface in response to follicle-stimulating hormone (FSH). Synthesis of GM3 was stimulated concentr...

journal_title：Molecular and cellular endocrinology

authors： Hattori M,Horiuchi R

更新日期：1992-10-01 00:00:00

abstract：:Corticotropin (ACTH) binds to specific receptors in the adrenal cortex and thereby regulates glucocorticoid and mineralocorticoid production. The number of ACTH binding sites on adrenocortical cells is increased by exposure of cells to activators of the cAMP pathway. The mechanism responsible for the increase in ACTH ...

journal_title：Molecular and cellular endocrinology

authors： Mountjoy KG,Bird IM,Rainey WE,Cone RD

更新日期：1994-02-01 00:00:00

abstract：:Obesity may cause several metabolic complications, including insulin resistance and type 2 diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and effective drugs for treatment of obesity and insulin resistance. The aim of this study was to survey if baicalin might ameliorate obesi...

journal_title：Molecular and cellular endocrinology

authors： Fang P,Yu M,Zhang L,Wan D,Shi M,Zhu Y,Bo P,Zhang Z

更新日期：2017-06-15 00:00:00

abstract：:We studied the functional properties of hepatic glucagon receptors during rat development. Glucagon binding to liver membranes and isolated hepatocytes was significantly less in foetuses and weaning rats than in adult animals, reflecting changes in the number of receptors rather than any change in receptor affinity fo...

journal_title：Molecular and cellular endocrinology

authors： Blázquez E,Perez Castillo A,de Diego JG

更新日期：1987-02-01 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroidal enzyme which, in breast cancer cells, mainly synthesizes 17-beta-estradiol (E2), an estrogenic hormone that stimulates breast cancer cell growth. We previously showed that the enzyme increased breast cancer cell proliferation via a dual effect on E2 ...

journal_title：Molecular and cellular endocrinology

authors： Aka JA,Calvo EL,Lin SX

更新日期：2017-01-05 00:00:00

abstract：:Proinsulin folding imperfections cause extensive beta-cell defects known in diabetes. Here, we investigated whether exenatide can alleviate such defects in proinsulin conversion, beta-cell survival, and insulin secretion, in the Ins2+/Akita beta-cells that have a spontaneous mutation (Cys 96 Tyr) in the insulin 2 gene...

journal_title：Molecular and cellular endocrinology

authors： Tang W,Yuan Q,Xu B,Osei K,Wang J

更新日期：2017-01-05 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) was found to induce type-1 plasminogen activator inhibitor (PAI-1) antigen in the human fibrosarcoma cell line HT-1080, and PAI-1 and urokinase-type plasminogen activator (u-PA) antigens in the human carcinoma cell line T-CAR1; tissue-type plasminogen activator (t-PA) antigen wa...

journal_title：Molecular and cellular endocrinology

authors： Georg B,Helseth E,Lund LR,Skandsen T,Riccio A,Danø K,Unsgaard G,Andreasen PA

更新日期：1989-01-01 00:00:00

abstract：:The members of stanniocalcins (STCs: STC-1 and STC-2) family are known to be involved in tumor progression and metastasis. Although current evidences suggest the involvement of STCs in vascular biology, the functional roles of STCs in angiogenesis have not yet been elucidated. The objective of this study was to deciph...

journal_title：Molecular and cellular endocrinology

authors： Law AY,Wong CK

更新日期：2013-07-15 00:00:00

abstract：:Thyroid hormone pretreatment was indicated to increase tissue tolerance to ischemia-reperfusion injury (IRI) in various organs, but the underlying molecular mechanisms remains largely unknown. Induction of heme oxygenase-1 (HO-1) protects organs against IRI. The present study investigated the effect of thyroid hormone...

journal_title：Molecular and cellular endocrinology

authors： Li F,Lu S,Zhu R,Zhou Z,Ma L,Cai L,Liu Z

更新日期：2011-06-06 00:00:00

abstract：:In the present paper the effects of 17beta-estradiol on the expression of the preprosomatostatin 1 (PSS1) in the orange-spotted grouper hypothalamus and ovary were investigated. Results from in vivo of intraperitoneal injection and in vitro static cultures showed that estradiol increased the mRNA expression of PSS1 ge...

journal_title：Molecular and cellular endocrinology

authors： Zhang L,Li W,Hong X,Lin H

更新日期：2009-11-13 00:00:00

abstract：:The human choriocarcinoma cell line, BeWo, synthesizes the glycoprotein hormone, human chorionic gonadotropin (hCG). We have undertaken this study to compare the synthesized and secreted forms of hCG and their alpha- and beta-subunits in cell cultures of BeWo cells to those forms of normal placental cells by immunobin...

journal_title：Molecular and cellular endocrinology

authors： Takeuchi Y,Sakakibara R,Ishiguro M

更新日期：1990-03-05 00:00:00

abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

journal_title：Molecular and cellular endocrinology

authors： Chun TY,Bloem L,Pratt JH

更新日期：2002-08-30 00:00:00

abstract：:The concentration of high-affinity estradiol binding sites in the uteri and pituitaries of normal and two dwarf strains of mice was studied. The two dwarf strains are characterized by their total absence of growth hormone or prolactin synthesis and low or absent TSH production. The uteri of the dwarf mice are small bu...

journal_title：Molecular and cellular endocrinology

authors： Sartor P,Slabaugh M,Sakai D,Gorski J

更新日期：1983-01-01 00:00:00

abstract：:Granulosa cells were isolated from antral follicles of intact, adult female rats by treatment with EGTA and hypertonic sucrose, and were kept in culture for 1, 15 or 37 days. The amount of inhibin-like activity in spent rat granulosa-cell media (rGCCM) was assessed by using a bioassay for inhibin (measurement of the u...

journal_title：Molecular and cellular endocrinology

authors： Hermans WP,van Leeuwen EC,Debets MH,Sander HJ,de Jong FH

更新日期：1982-08-01 00:00:00

abstract：:A peptide of unknown structure was found as a side product in a commercial preparation of the 1-34 fragment of bovine parathyroid hormone (PTH). CNBr cleavage and amino acid analysis showed that this peptide is the des-lys-13 form of 1-34 bovine PTH. The peptide thus represents a deletion mutant of PTH and structure-f...

journal_title：Molecular and cellular endocrinology

authors： Zull JE,Smith LM,Chuang J,Jentoft J

更新日期：1987-06-01 00:00:00

abstract：:Four abundant cDNA clones have been isolated from a rat epididymal cDNA library. Northern blot analysis has shown that these clones partially encode 4.5 kb, 2.8 kb, 1.2 kb and 0.85 kb mRNAs and that their expression is not detectable in total RNA preparations from heart, kidney, liver or testis. Fourteen days after ca...

journal_title：Molecular and cellular endocrinology

authors： Walker JE,Jones R,Moore A,Hamilton DW,Hall L

更新日期：1990-11-12 00:00:00

abstract：:The interaction of indomethacin with the antilipolytic effect of prostaglandin E2 (PGE2) was investigated in rat adipocytes in order to reveal a possible role of endogenous PGs in adipose tissue. Adipocytes isolated from rats treated in vivo for 5 days with indomethacin were compared with non-treated control rats. The...

journal_title：Molecular and cellular endocrinology

authors： Richelsen B

更新日期：1988-07-01 00:00:00

abstract：:Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are widely recognized for their roles in ovulation and the support of early pregnancy. Aside from the timing of expression, however, the differences between LH and hCG have largely been overlooked in the clinical realm because of their similar molecular s...

journal_title：Molecular and cellular endocrinology

authors： Choi J,Smitz J

更新日期：2014-03-05 00:00:00

abstract：:Osteoblastic metastases are common in patients with advanced prostate cancer. The pathophysiology of the new bone formation at metastatic sites is not currently known, but it is hypothesized that growth factors secreted by the prostate may be involved. Unfortunately, most rodent models of prostate cancer with metastas...

journal_title：Molecular and cellular endocrinology

authors： LeRoy BE,Bahnson RR,Rosol TJ

更新日期：2002-11-29 00:00:00

abstract：OBJECTIVE:Significant attempts are being made to generate multifunctional, hybrid or peptide combinations as novel therapeutic strategies for type 2 diabetes, however this presents key challenges including design and pharmaceutical development. In this study, we evaluated metabolic properties of oral nutritional supple...

journal_title：Molecular and cellular endocrinology

authors： Pathak NM,Millar PJB,Pathak V,Flatt PR,Gault VA

更新日期：2018-01-15 00:00:00

abstract：:We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deac...

journal_title：Molecular and cellular endocrinology

authors： Tao RH,Kawate H,Wu Y,Ohnaka K,Ishizuka M,Inoue A,Hagiwara H,Takayanagi R

更新日期：2006-03-09 00:00:00

abstract：:Prostaglandin A1 (PGA1) increases heat shock element (HSE)-mediated transcription, thereby enhancing expression of HSE-bearing genes, including heat shock proteins. Because we recently found functional HSEs in the human and rodent c-fos promoters, we hypothesized that PGA1 might increase c-fos expression through the H...

journal_title：Molecular and cellular endocrinology

authors： Ishikawa T,Sekine N,Hata K,Igarashi T,Fujita T

更新日期：2000-06-01 00:00:00

abstract：:Since all-trans retinoic acid (ATRA) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of ATRA on thyroid carcinoma and to evaluate the effectiveness of ATRA in redifferentiation induction of thyroid carcinoma. Therefore, we investigated cell growth rate,...

journal_title：Molecular and cellular endocrinology

authors： Malehmir M,Haghpanah V,Larijani B,Ahmadian S,Alimoghaddam K,Heshmat R,Ghavamzadeh A,Adabi K,Ghaffari SH

更新日期：2012-01-02 00:00:00

abstract：:Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential h...

journal_title：Molecular and cellular endocrinology

authors： Monticone S,Else T,Mulatero P,Williams TA,Rainey WE

更新日期：2015-01-05 00:00:00

abstract：:Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by progesterone or synthetic progestins. Estrogen and progestin action is regulated at the pre-receptor level, by interconversion of active hormones (estradiol (E2), prog...

journal_title：Molecular and cellular endocrinology

authors： Rizner TL,Smuc T,Rupreht R,Sinkovec J,Penning TM

更新日期：2006-03-27 00:00:00

abstract：:In light of current discussions on multiple forms of inhibin, it was thought of interest to ascertain the identity of the postulated 'iso-hormones' of bull seminal plasma inhibin (Chari et al., 1978). By subjecting the biologically active fraction, obtained by Sephadex G-100 gel filtration of bull seminal plasma aceto...

journal_title：Molecular and cellular endocrinology

authors： Mohapatra SK,Duraiswami S,Chari S

更新日期：1985-07-01 00:00:00