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Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation.

Abstract：

:Since all-trans retinoic acid (ATRA) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of ATRA on thyroid carcinoma and to evaluate the effectiveness of ATRA in redifferentiation induction of thyroid carcinoma. Therefore, we investigated cell growth rate, morphological and nuclear: cytoplasmic ratio, adherent-dependent growth, response to chemotherapy drug following differentiation, T3 and T4 measurement, and critical genes expression pattern. Papillary cell line showed more growth inhibition by ATRA, in addition, mesenchymal and spindle-shape of 8305C cells changed to polygonal. Additionally, high nuclear: cytoplasmic ratio of anaplastic decreased significantly. Redifferentiation significantly suppressed the anchorage-dependent growth in the both cell lines in a dose-dependent manner, potentiated the arsenic trioxide (ATO) effects in anaplastic and papillary cell lines. Furthermore, reduction in the expression of stemness, and invasion related genes was observed in the both cell lines. Altogether, ATRA treatment could hold the aggressive behavior of thyroid carcinoma in restraint and/or potentiate the effect of chemotherapy drug ATO.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Malehmir M,Haghpanah V,Larijani B,Ahmadian S,Alimoghaddam K,Heshmat R,Ghavamzadeh A,Adabi K,Ghaffari SH

doi

10.1016/j.mce.2011.09.002

subject

Has Abstract

pub_date

2012-01-02 00:00:00

pages

260-9

issue

1

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(11)00536-3

journal_volume

348

pub_type

杂志文章

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