ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines.

abstract：:The NAD+ dependent (K or type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase oxidizes glucocorticoids and thus prevents them from occupying mineralocorticoid receptors. Mutations in the HSD11K (HSD11B2) gene encoding this isozyme cause a genetic form of hypertension, the syndrome of apparent mineralocorticoid exce...

journal_title：Molecular and cellular endocrinology

authors： Agarwal AK,White PC

更新日期：1996-07-23 00:00:00

abstract：:Microcirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and preven...

journal_title：Molecular and cellular endocrinology

authors： Herrera NA,Duchatsch F,Tardelli LP,Dionísio TJ,Shinohara AL,Santos CF,Amaral SL

更新日期：2020-04-05 00:00:00

abstract：:We have designed and synthesized a biotinylated vasopressin antagonist which is a selective probe for studying the V1a subtype of vasopressin receptor. Initially we synthesized the novel vasopressin analogue d(CH2)5Tyr(Me)2LysNH2(9)AVP (ALVP). Biotinamidocaproate was subsequently coupled to the epsilon-amino group of ...

journal_title：Molecular and cellular endocrinology

authors： Howl J,Kerr ID,Chan CH,Wheatley M

更新日期：1991-05-01 00:00:00

abstract：:The binding of triiodothyronine (T3) to tadpole liver, intestine, and tail fin nuclei was consistent with a single class of binding sites. The KD for the binding of T3 to isolated nuclei from the liver (1.02 nM), intestine (1.40 nM), and tail fin (0.831 nM) nuclei were not significantly different. The number of bindin...

journal_title：Molecular and cellular endocrinology

authors： Jaffe RC

更新日期：1987-07-01 00:00:00

abstract：:Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have been studied in many tissues and organs over decades. GH and IGF-1 are part of the hypothalamic/pituitary somatotrophic axis that consists of man...

journal_title：Molecular and cellular endocrinology

authors： Dixit M,Poudel SB,Yakar S

更新日期：2021-01-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) is a stroma-derived mitogen mediating epithelial-stromal interactions. We investigated the role of KGF during epithelial-stromal interactions accompanying ruminant mammogenesis. Target-specificity of KGF was demonstrated in that KGF-stimulated proliferation of bovine mammary epithelial...

journal_title：Molecular and cellular endocrinology

authors： Hovey RC,Davey HW,Vonderhaar BK,Mackenzie DD,McFadden TB

更新日期：2001-07-05 00:00:00

abstract：:The free radical, or oxidative stress, theory posits that imbalance in cells between prooxidants and antioxidants results in an altered redox state and, over time, an accumulation of oxidative damage. We hypothesized herein that cells with an increasingly prooxidant intracellular environment also might be particularly...

journal_title：Molecular and cellular endocrinology

authors： Chen H,Zhou L,Lin CY,Beattie MC,Liu J,Zirkin BR

更新日期：2010-07-29 00:00:00

abstract：:Diabetes-induced neutrophil NETosis impairs wound healing through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-triggered activation of mitogen-activated protein kinase (MAPK) ERK1/2 and p38 is involved in NETosis. Hydrogen sulfide (H2S), an endogenous signaling molecule, accelerates diabetic wo...

journal_title：Molecular and cellular endocrinology

authors： Yang CT,Chen L,Chen WL,Li N,Chen MJ,Li X,Zheng X,Zhao YZ,Wu YX,Xian M,Liu J

更新日期：2019-01-15 00:00:00

abstract：:Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin-associated proteins include G protein-coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinase...

journal_title：Molecular and cellular endocrinology

authors： Luoma JI,Boulware MI,Mermelstein PG

更新日期：2008-08-13 00:00:00

abstract：:The functional significance of two unlinked human vitamin D receptor (hVDR) gene polymorphisms was evaluated in twenty human fibroblast cell lines. Genotypes at both a Fok I restriction site (F/f) in exon II and a singlet (A) repeat in exon IX (L/S) were determined, and relative transcription activities of endogenous ...

journal_title：Molecular and cellular endocrinology

authors： Whitfield GK,Remus LS,Jurutka PW,Zitzer H,Oza AK,Dang HT,Haussler CA,Galligan MA,Thatcher ML,Encinas Dominguez C,Haussler MR

更新日期：2001-05-25 00:00:00

abstract：:Follistatin (FS) is well characterized as an activin-binding protein. Recently, a novel follistatin-like protein called follistatin-related gene (FLRG) that has a similar domain organization to that of follistatin has been identified. Like follistatins, FLRG binds activins and bone morphogenetic proteins (BMPs). To st...

journal_title：Molecular and cellular endocrinology

authors： Nakatani M,Yamakawa N,Matsuzaki T,Shimasaki S,Sugino H,Tsuchida K

更新日期：2002-03-28 00:00:00

abstract：:We used murine Ba/F3 cells transfected with human growth hormone receptor (hGHR) cDNA to investigate the regulatory mechanisms of human growth hormone-binding protein (hGH-BP) release. The extracellular domain of hGHRs were cleaved and released as hGH-BPs (a soluble form of hGHR). The hGH-BP release was enhanced by ph...

journal_title：Molecular and cellular endocrinology

authors： Takagi K,Saito Y,Sawada J

更新日期：2001-09-01 00:00:00

abstract：:We investigated the involvement of protein synthesis in the stimulatory action of thyroid hormones on amino acid accumulation and characterized K(+) currents involved in the hyperpolarizing effect of thyroxine (T(4)) on Sertoli cells. Immature rat testes were incubated in Krebs Ringer-bicarbonate buffer (KRb) in the p...

journal_title：Molecular and cellular endocrinology

authors： Menegaz D,Zamoner A,Royer C,Leite LD,Bortolotto ZA,Silva FR

更新日期：2006-02-26 00:00:00

abstract：:It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confi...

journal_title：Molecular and cellular endocrinology

authors： Walters KA,Handelsman DJ

更新日期：2018-04-15 00:00:00

abstract：:Functional development of the ventral prostate and seminal vesicles in the male rat has been examined by incubating tissue with [35S] methionine and using specific antisera to detect the synthesis of individual marker proteins. 4 major secretory proteins of the seminal vesicles were chosen along with 4 major prostatic...

journal_title：Molecular and cellular endocrinology

authors： Higgins SJ,Smith SE,Wilson J

更新日期：1982-06-01 00:00:00

abstract：:Somatostatin (SS) and its synthetic analogs have a role in the treatment of neuroendocrine tumours both in terms of symptoms control and antiproliferative activities. These effects are mediated by five SS receptors, widely expressed in both human neuroendocrine and non-neuroendocrine tumours, which were demonstrated t...

journal_title：Molecular and cellular endocrinology

authors： Volante M,Rosas R,Allìa E,Granata R,Baragli A,Muccioli G,Papotti M

更新日期：2008-05-14 00:00:00

abstract：:Using dispersed cultures of fetal rat hypothalami, we studied the effects of forskolin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), activators of protein kinase A and C, respectively, upon vasopressin (VP) secretion, VP mRNA expression and VP mRNA poly(A) tail length. Forskolin stimulated the VP m...

journal_title：Molecular and cellular endocrinology

authors： Emanuel RL,Girard DM,Thull DL,Majzoub JA

更新日期：1992-07-01 00:00:00

abstract：:The apparent preferential expression of the elastase/cathepsin G protease inhibitor antileukoproteinase (ALP) in endometrium of species with epitheliochorial placenta suggests mechanisms of transcriptional regulation unique to these mammalian species. To begin to define the cis-acting regulatory elements involved in t...

journal_title：Molecular and cellular endocrinology

authors： Simmen RC,Badinga L,Michel FJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND/PURPOSE:It remains unclear what role curcumin plays in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis, since some researchers found that curcumin has the ability to inhibit osteoclastogenesis. While others have considered it as an autophagy activator. This study aimed to determine th...

journal_title：Molecular and cellular endocrinology

authors： Ke D,Wang Y,Yu Y,Wang Y,Zheng W,Fu X,Han J,Zhang G,Xu J

更新日期：2020-01-15 00:00:00

abstract：:To elucidate the molecular mechanism in relation to vascular supply and osteoporosis, we investigated the effect of hypoxia on Runx2 expression in MG63 cells. Also investigated was expression of type I collagen and osteocalcin, which are regulated by Runx2, alkaline phosphatase (ALPase) to see if they are affected by ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Park BH,Kim HK,Park TS,Baek HS

更新日期：2002-06-28 00:00:00

abstract：:The present experiment used cultured mouse cumulus cell-enclosed oocytes (CEOs) and denuded oocytes (DOs) to study the function of nitric oxide (NO) in mouse oocyte meiotic maturation. Either positive or negative actions of NO on meiotic maturation has been observed when CEOs or DOs were cultured for 24 h in a medium ...

journal_title：Molecular and cellular endocrinology

authors： Bu S,Xia G,Tao Y,Lei L,Zhou B

更新日期：2003-09-30 00:00:00

abstract：:The effect of a gonadotropin-releasing hormone-agonist (GnRH-a) on the synthesis of insulin-like growth factor-binding protein-5 (IGFBP-5), a physiological marker for atresia, was investigated. Granulosa cells obtained from diethylstilbestrol (DES)-treated immature female rats were cultured in serum-free medium for 72...

journal_title：Molecular and cellular endocrinology

authors： Onoda N,Li D,Mickey G,Erickson G,Shimasaki S

更新日期：1995-04-28 00:00:00

abstract：:Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesi...

journal_title：Molecular and cellular endocrinology

authors： Louw-du Toit R,Storbeck KH,Cartwright M,Cabral A,Africander D

更新日期：2017-02-05 00:00:00

abstract：:Delphinidin possesses the highest chemopreventive activity among the six components of anthocyanidin that are pigments from fruits and vegetables giving them blue, purple or red colors. Although delphinidin has anti-carcinogenic and apoptotic effects in various cancers, little is known about its functional roles in ov...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Jeong W,Song G

更新日期：2016-02-15 00:00:00

abstract：:Receptors for calcitriol are described in human decidua. They exhibit a dissociation constant of 35 +/- 6 pM and they are at concentrations similar to those found in other tissues (0.45 +/- 0.04 fmol/micrograms DNA). They are highly specific for calcitriol since neither of the other vitamin D3 derivatives nor the ster...

journal_title：Molecular and cellular endocrinology

authors： Delvin EE,Gagnon L,Arabian A,Gibb W

更新日期：1990-07-09 00:00:00

abstract：:Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid-binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-deple...

journal_title：Molecular and cellular endocrinology

authors： Krautbauer S,Haberl EM,Eisinger K,Pohl R,Rein-Fischboeck L,Rentero C,Alvarez-Guaita A,Enrich C,Grewal T,Buechler C,Neumeier M

更新日期：2017-01-05 00:00:00

abstract：:Tibolone, a synthetic steroid used for the prevention of osteoporosis and the treatment of climacteric symptoms in post-menopausal women, may exert tissue selective estrogenic actions acting on estrogen receptors (ERs). We previously showed that tibolone protects human T98G astroglial cells against glucose deprivation...

journal_title：Molecular and cellular endocrinology

authors： Avila-Rodriguez M,Garcia-Segura LM,Hidalgo-Lanussa O,Baez E,Gonzalez J,Barreto GE

更新日期：2016-09-15 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a member of a family of cytokines that regulate differentiation and proliferation in a wide variety of tissues including the pituitary gland. In both the normal pituitary and tumorous cell lines TGF-beta1 has anti-proliferative activity, however the intracellular mechanism...

journal_title：Molecular and cellular endocrinology

authors： Frost SJ,Simpson DJ,Farrell WE

更新日期：2001-05-15 00:00:00

abstract：:Immature female rats were injected with a single dose (10 IU) of pregnant mare serum gonadotropin to induce growth and maturation of ovarian follicles. Using such ovaries as a model, we tested the effects of low molecular weight subfractions of charcoal-absorbed bovine follicular fluid (FF-c) on (a) radioiodinated hum...

journal_title：Molecular and cellular endocrinology

authors： Fletcher PW,Dias JA,Sanzo MA,Reichert LE Jr

更新日期：1982-03-01 00:00:00

abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

journal_title：Molecular and cellular endocrinology

authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

更新日期：1999-11-25 00:00:00