Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones.

abstract：:In the 40 years of transferrin research, no previous role for apotransferrin has been recognized other than to serve as a plasma carrier for dietary and storage iron. Our studies have revealed a new 'autocrine' growth role for this molecule as well as a possible new cell-cell bridge/CAM function. Certainly, these obse...

journal_title：Molecular and cellular endocrinology

authors： Sirbasku DA,Pakala R,Sato H,Eby JE

更新日期：1991-05-01 00:00:00

abstract：:The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6...

journal_title：Molecular and cellular endocrinology

authors： van Haastert PJ,van Walsum H,van der Meer RC,Bulgakov R,Konijn TM

更新日期：1982-02-01 00:00:00

abstract：:In order to study the control of vasopressin-release, the effect of a series of potential agents was studied in an in vitro perifusion system of rat neurohypophysis after in vivo treatment with nialamide, a monoamine oxidase inhibitor. In this system, metlatonin stimulated vasopressin-release in a dose-dependent manne...

journal_title：Molecular and cellular endocrinology

authors： Lemay A,Brouillette A,Denizeau F,Lavoie M

更新日期：1979-05-01 00:00:00

abstract：:Obesity may cause several metabolic complications, including insulin resistance and type 2 diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and effective drugs for treatment of obesity and insulin resistance. The aim of this study was to survey if baicalin might ameliorate obesi...

journal_title：Molecular and cellular endocrinology

authors： Fang P,Yu M,Zhang L,Wan D,Shi M,Zhu Y,Bo P,Zhang Z

更新日期：2017-06-15 00:00:00

abstract：:Phospholipase C (PHL-C) activity determined in homogenates of fat cells treated with physiological concentrations of insulin showed a 2-3-fold increase as compared to controls in the absence of insulin. The changes of PHL-C and pyruvate dehydrogenase (PDH) activity which was measured concomitantly exhibited very simil...

journal_title：Molecular and cellular endocrinology

authors： Koepfer-Hobelsberger B,Wieland OH

更新日期：1984-06-01 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

journal_title：Molecular and cellular endocrinology

authors： Lewy H,Ashkenazi IE,Naor Z

更新日期：2003-05-30 00:00:00

abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

journal_title：Molecular and cellular endocrinology

authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

更新日期：2016-05-15 00:00:00

abstract：:Thyroid dysgenesis is the most frequent cause of congenital hypothyroidism, but its molecular pathophysiology is largely unknown. Our hypothesis that some genes downstream to thyroid transcription factor-2 (TTF-2) might be responsible for development of the thyroid prompted us to identify genes whose expression is sti...

journal_title：Molecular and cellular endocrinology

authors： Hishinuma A,Ohmika N,Namatame T,Ieiri T

更新日期：2004-06-30 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant e...

journal_title：Molecular and cellular endocrinology

authors： Breitling R,Krazeisen A,Möller G,Adamski J

更新日期：2001-01-22 00:00:00

abstract：:Adrenocortical cancer is a rare malignancy for which current pharmacological therapies are still insufficient. We tested the effect of a novel PI3 kinase - mammalian target of rapamycin dual inhibitor (NVP-BEZ235) on proliferation of the H295R adrenocortical cancer cell line in vitro and grown as xenografts in immunod...

journal_title：Molecular and cellular endocrinology

authors： Doghman M,Lalli E

更新日期：2012-11-25 00:00:00

abstract：:The thyroid hormone receptors (TR) are able to bind DNA and to repress transcription in the absence of thyroid hormone. This repression function is an important feature of TRs as aberrant silencing can lead to severe diseases and developmental abnormalities. TR utilizes different mechanisms to achieve repression of ta...

journal_title：Molecular and cellular endocrinology

authors： Eckey M,Moehren U,Baniahmad A

更新日期：2003-12-31 00:00:00

abstract：:Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G(1)-S phase cell cycle progression. We investigated this cooperativity by evaluating if the key cell cycle regulators, c-Myc and cyclin D1, represent points of conv...

journal_title：Molecular and cellular endocrinology

authors： Mawson A,Lai A,Carroll JS,Sergio CM,Mitchell CJ,Sarcevic B

更新日期：2005-01-14 00:00:00

abstract：:The angiotensin II (AngII) type 1 (AT(1)) receptor is a seven-transmembrane G protein-coupled receptor, and is involved in regulating the physiological and pathological process of the cardiovascular system. Systemically and locally generated AngII has agonistic action on AT(1) receptor, but recent studies have demonst...

journal_title：Molecular and cellular endocrinology

authors： Akazawa H,Yasuda N,Komuro I

更新日期：2009-04-29 00:00:00

abstract：:Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events. To determine whether calcium or DREAM may play a role in linking these processes, we used an L-type Ca(2+)-blocker (nimodipine) and found that not only GnRH gene expression (GnRH-GE) pulse act...

journal_title：Molecular and cellular endocrinology

authors： Leclerc GM,Boockfor FR

更新日期：2007-03-15 00:00:00

abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

journal_title：Molecular and cellular endocrinology

authors： Scammell JG,Wear LB,Von Haven R

更新日期：1990-06-18 00:00:00

abstract：:Diabetes exacerbates neuronal injury mediated through neurotransmitters deregulation in cerebral cortex. Our study analyzed the neuroprotective effect of curcumin to prevent cortical dysfunction associated with diabetes. Our study revealed decreased gene expression of muscarinic M1, insulin receptor, SOD, choline acet...

journal_title：Molecular and cellular endocrinology

authors： Peeyush Kumar T,Antony S,Soman S,Kuruvilla KP,George N,Paulose CS

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Mono-2-ethylhexyl phthalate (MEHP), an important metabolite of di (2-ethylhexyl) phthalate (DEHP), can induce lipid metabolic disorder. Previous studies have shown that MEHP promotes 3T3-L1 cell differentiation; however, the underlying mechanism is unclear. The present study was performed to investigate the ...

journal_title：Molecular and cellular endocrinology

authors： Qi W,Zhou L,Zhao T,Ding S,Xu Q,Han X,Zhao Y,Song X,Zhao T,Zhang X,Ye L

更新日期：2019-03-15 00:00:00

abstract：:Inhibin A and B are dimeric proteins capable of suppressing FSH both in vitro and in vivo. The principal form in the male is inhibin B which is produced in the testis and circulates to inhibit pituitary FSH secretion. Activin A, B and AB are dimeric proteins that share the same beta subunits with the inhibins but, in ...

journal_title：Molecular and cellular endocrinology

authors： de Kretser DM,Meinhardt A,Meehan T,Phillips DJ,O'Bryan MK,Loveland KA

更新日期：2000-03-30 00:00:00

abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

journal_title：Molecular and cellular endocrinology

authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1989-06-01 00:00:00

abstract：:In order to differentiate whether activation of NaK-ATPase in thyroid thermogenesis is due to increased numbers of active 'sodium pump' units or due to a change in the kinetics of the enzyme, the effect of T3 on activation energy (Ea) of NaK-ATPase was determined in rat liver, kidney and brain. Injection of T3 produce...

journal_title：Molecular and cellular endocrinology

authors： Rahimifar M,Ismail-Beigi

更新日期：1977-02-01 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is the common precursor of several pituitary hormones including alpha-melanotropic hormone, adrenocorticotropic hormone, beta-lipotropin and beta-endorphin. The porcine POMC cDNA was inserted downstream from the late promoter of an SV40-derived expression vector and co-transfected in NIH 3T...

journal_title：Molecular and cellular endocrinology

authors： Zollinger L,Noël G,Des Parois L,Sales V,Crine P,Boileau G

更新日期：1988-07-01 00:00:00

abstract：:Increased production of inflammatory cytokines is suggested to be of importance for initiation and progression of insulin resistance. Chronic treatment with the AMP analogue 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR) has been shown to improve insulin sensitivity and prevent the development of diabe...

journal_title：Molecular and cellular endocrinology

authors： Lihn AS,Pedersen SB,Lund S,Richelsen B

更新日期：2008-09-24 00:00:00

abstract：:It has been previously shown that corticotropin-releasing hormone (CRH) exerts antiproliferative activity on an estrogen-dependent tumor cell line, i.e. human endometrial adenocarcinoma Ishikawa (IK) cells. Here we have investigated the effects of CRH on another estrogen-dependent tumor cell line, human breast cancer ...

journal_title：Molecular and cellular endocrinology

authors： Graziani G,Tentori L,Muzi A,Vergati M,Tringali G,Pozzoli G,Navarra P

更新日期：2007-01-29 00:00:00

abstract：:Agrochemicals or pesticides are compounds widely used to prevent, destroy or mitigate pests such as insects, rodents, herbs and weeds. However, most of them also act as environmental estrogens, anti-estrogens and/or antiandrogenic chemicals. In addition, both herbicides (such as glyphosate and paraquat) and insecticid...

journal_title：Molecular and cellular endocrinology

authors： Rossetti MF,Stoker C,Ramos JG

更新日期：2020-06-15 00:00:00

abstract：:Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-k...

journal_title：Molecular and cellular endocrinology

authors： Kuil CW,Mulder E

更新日期：1994-06-01 00:00:00

abstract：:The cDNA encoding the bovine activin type II receptor has been cloned by reverse transcription-polymerase chain reaction (RT-PCR) amplification of a bovine testicular RNA preparation. Sequence comparisons of the bovine activin type II receptor with its human, mouse and rat homologues show strong evolutionary conservat...

journal_title：Molecular and cellular endocrinology

authors： Ethier JF,Houde A,Lussier JG,Silversides DW

更新日期：1994-12-01 00:00:00

abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is essential for the biosynthesis of all active steroid hormones. The 3beta-HSD enzyme consists in multiple isoforms, each the product of a distinct gene. In the mouse, six tissue-specific isoforms have been identified. These isoforms are expressed in...

journal_title：Molecular and cellular endocrinology

authors： Peng L,Arensburg J,Orly J,Payne AH

更新日期：2002-02-22 00:00:00

abstract：:Several lines of evidence indicate that the number of GnRH receptors (GnRH-R) and therefore, gonadotrope responsiveness to GnRH, is highly dependent upon the level of GnRH-R mRNA. To explore this aspect of regulation, we have isolated a 3.3 kb fragment encompassing the promoter region of the rat GnRH-R gene. Primer ex...

journal_title：Molecular and cellular endocrinology

authors： Pincas H,Forraï Z,Chauvin S,Laverrière JN,Counis R

更新日期：1998-09-25 00:00:00

abstract：:Porcine Leydig cells in primary culture were incubated to equilibrium with increasing doses of either porcine luteinizing hormone (pLH) or human chorionic gonadotropin (hCG). Then, free and total high affinity gonadotropin receptors on the cell surface were dosed with [125I]hCG as tracer. In isotonic high salt medium,...

journal_title：Molecular and cellular endocrinology

authors： Genty N,Salesse R,Jallal B,Garnier J

更新日期：1991-04-01 00:00:00