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Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats.

Abstract：

:Diabetes exacerbates neuronal injury mediated through neurotransmitters deregulation in cerebral cortex. Our study analyzed the neuroprotective effect of curcumin to prevent cortical dysfunction associated with diabetes. Our study revealed decreased gene expression of muscarinic M1, insulin receptor, SOD, choline acetyl transferase and increased gene expression of muscarinic M3, α7-nicotinic acetylcholine receptor, acetylcholine esterase and GLUT3 in cerebral cortex of diabetic rats. Curcumin and insulin treatment reversed this altered parameters to near control. Immunohistochemistry studies of muscarinic M1 and M3 confirmed the gene expression at protein level. Decreased novel arm entry of diabetic rats in Y-maze test, improved in treatment group. These results suggest that cholinergic dysfunction, impaired glucose transport and oxidative stress contributes to learning and memory deficits in diabetes and further suggest that antioxidant curcumin has potential therapeutic role in preventing and/or delaying the diabetic complications associated with brain.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Peeyush Kumar T,Antony S,Soman S,Kuruvilla KP,George N,Paulose CS

doi

10.1016/j.mce.2010.07.004

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1-10

issue

1

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(10)00365-5

journal_volume

331

pub_type

杂志文章

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