Thyroid hormone regulation of rat pituitary tumor cell growth: a new role for apotransferrin as an autocrine thyromedin.

abstract：:The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmit...

journal_title：Molecular and cellular endocrinology

authors： Zemková H,Stojilkovic SS

更新日期：2018-03-05 00:00:00

abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

journal_title：Molecular and cellular endocrinology

authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

更新日期：2019-01-15 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:The role of estrogens produced by the testis may involve negative feedback regulation of androgen biosynthesis. Estrogens are also associated with contractile processes of seminiferous tubules, and might have mitogenic effects on Sertoli and Leydig cells. To investigate the location of aromatase (estrogen synthetase) ...

journal_title：Molecular and cellular endocrinology

authors： Brodie A,Inkster S,Yue W

更新日期：2001-06-10 00:00:00

abstract：:Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin-associated proteins include G protein-coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinase...

journal_title：Molecular and cellular endocrinology

authors： Luoma JI,Boulware MI,Mermelstein PG

更新日期：2008-08-13 00:00:00

abstract：:Border cell migration is a process that occurs during Drosophila ovarian development in which cells derived from a simple epithelium migrate and invade neighboring tissue. This process resembles the behavior of cancerous cells that derive from the simple epithelium of the human ovary. One important regulator of border...

journal_title：Molecular and cellular endocrinology

authors： Yoshida H,Liu J,Samuel S,Cheng W,Rosen D,Naora H

更新日期：2005-12-21 00:00:00

abstract：:The effects of propylthiouracil (PTU) treatment on vasopressin, angiotensin II, glucagon and alpha 1-adrenergic receptors in both developing and adult rats were studied in liver membrane preparations by measuring the binding of the following ligands: [3H][8-lysine]vasopressin, [3H]Sar-angiotensin II, [125I]glucagon an...

journal_title：Molecular and cellular endocrinology

authors： Ali M,Cantau B,Chicot D,Clos J

更新日期：1987-05-01 00:00:00

abstract：:Deficiency of adrenal hormones promotes exacerbated neutrophil influx into inflammatory sites. We investigated the effect of adrenal deficiency on neutrophil mobilization comparing adrenalectomized (ADX) male Wistar rats to sham-operated (SO) or non-manipulated (N) animals, as controls. Seven days after surgeries, the...

journal_title：Molecular and cellular endocrinology

authors： Cavalcanti DM,Lotufo CM,Borelli P,Tavassi AM,Pereira AL,Markus RP,Farsky SH

更新日期：2006-04-25 00:00:00

abstract：:The involvement of cyclic-AMP (cAMP) as a potential second messenger in the neurohormonal control of ovarian steroidogenesis was investigated in the adult female blowfly Phormia regina. Individual measurements of ovarian cAMP concentrations and of ovarian biosynthesis of ecdysteroids, stimulated after a protein meal, ...

journal_title：Molecular and cellular endocrinology

authors： Manière G,Vanhems E,Delbecque J

更新日期：2000-10-25 00:00:00

abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

journal_title：Molecular and cellular endocrinology

authors： Chun TY,Bloem L,Pratt JH

更新日期：2002-08-30 00:00:00

abstract：:Key reproductive events, such as menstruation and implantation, are considered to be inflammatory processes and glucocorticoids act as anti-inflammatory agents. The balance of expression of types 1 and 2 11beta-hydroxysteroid dehydrogenases (11betaHSD) controls the availability of cortisol to bind to the glucocorticoi...

journal_title：Molecular and cellular endocrinology

authors： McDonald SE,Henderson TA,Gomez-Sanchez CE,Critchley HO,Mason JI

更新日期：2006-03-27 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:In the frog Xenopus laevis, vitellogenin is the major estrogen-induced protein in the liver. We have characterized an additional secreted protein, of 45,000 Da and designated Ep45, which is also responsive to estrogen treatment. Like vitellogenin, Ep45 is not normally found in the plasma nor synthesized by the liver o...

journal_title：Molecular and cellular endocrinology

authors： Holland LJ,Wangh LJ

更新日期：1987-01-01 00:00:00

abstract：:Forskolin, a diterpene hypotensive drug, activates adenylate cyclase in brain and in some other tissues (Seamon et al., 1981). Forskolin activated adenylate cyclase in particulate preparations and enhanced cyclic AMP accumulation in slices of dog thyroid. These effects were maximal within minutes and remained constant...

journal_title：Molecular and cellular endocrinology

authors： Van Sande J,Cochaux P,Mockel J,Dumont JE

更新日期：1983-01-01 00:00:00

abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

journal_title：Molecular and cellular endocrinology

authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1989-06-01 00:00:00

abstract：:To determine if the hormonal effects on insulin-like growth factor binding protein (IGFBP) production differed between granulosa and thecal cells, both cell types were collected and cultured in serum-free medium with various hormone treatments, arranged in three experiments. Following treatment, cells were enumerated ...

journal_title：Molecular and cellular endocrinology

authors： Chamberlain CS,Spicer LJ

更新日期：2001-08-20 00:00:00

abstract：:On the surface of the free (receptor-unbound) form of hCG, we have previously identified 14 topographically distinct epitopes (Schwarz et al. (1986) Endocrinology 118, 189-197; Berger et al. (1990) J. Endocrinol. 125, 301-309). Here we report that only two of them, i.e. the (adjacent) beta 3 and beta 5 epitopes, can b...

journal_title：Molecular and cellular endocrinology

authors： Schwarz S,Krude H,Wick G,Berger P

更新日期：1991-11-01 00:00:00

abstract：:Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-k...

journal_title：Molecular and cellular endocrinology

authors： Kuil CW,Mulder E

更新日期：1994-06-01 00:00:00

abstract：:Imprinted gene expression in preimplantation development has been extensively studied in the mouse. Different imprinted genes vary in their time of onset of expression and also in the timing and tissue-specificity of mono-allelic expression. We have surveyed a range of imprinted genes for expression, and mono-allelic ...

journal_title：Molecular and cellular endocrinology

authors： Monk M,Salpekar A

更新日期：2001-10-22 00:00:00

abstract：:Dopamine and somatostatin are both involved in the negative control of normal pituitary cells. Dopamine subtype 2 receptor (D2DR) and somatostatin receptor (sst) agonists, mainly directed to sst2, are used in the treatment of pituitary adenomas. Nevertheless, a majority of corticotroph and gonadotroph adenomas and a t...

journal_title：Molecular and cellular endocrinology

authors： Saveanu A,Jaquet P,Brue T,Barlier A

更新日期：2008-05-14 00:00:00

abstract：:Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung cancer line (BEN cells). Northern analysis demonstrated that calcitonin caused a rapid 4.5-fold elevation in PTHrP mRNA. Transient transfection of a construct containing 1119 base pairs of the ...

journal_title：Molecular and cellular endocrinology

authors： Chilco PJ,Gerardi JM,Kaczmarczyk SJ,Chu S,Leopold V,Zajac JD

更新日期：1993-07-01 00:00:00

abstract：:Glucose uptake by brown adipose tissue, measured following deoxyglucose injection in vivo, was increased by 6- and 11-fold following 2 and 14 days of cold exposure, respectively. To look for the possible mechanism of these modifications, the glucose transporter Glut 4 has been characterized at the protein and mRNA lev...

journal_title：Molecular and cellular endocrinology

authors： Olichon-Berthe C,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1992-11-01 00:00:00

abstract：:Activating mutations in the follicle-stimulating hormone (FSH) receptor (FSHR) gene are rarely detected due to the absence of a clearly defined phenotype, particularly in men. We here report the biochemical features of a novel mutation in the first extracellular loop of the FSHR. The mutation (N431I) was detected in a...

journal_title：Molecular and cellular endocrinology

authors： Casas-González P,Scaglia HE,Pérez-Solís MA,Durand G,Scaglia J,Zariñán T,Dias JA,Reiter E,Ulloa-Aguirre A

更新日期：2012-11-25 00:00:00

abstract：:Interaction of tamoxifen, trioxifene and LY117018 with cytosol-estrogen receptors from immature rat uteri was compared. Determination of relative binding affinity (RBA) by competition with [3H] estradiol under various assay conditions revealed that the RBA of LY117018 increased with temperature while that of trioxifen...

journal_title：Molecular and cellular endocrinology

authors： Black LJ,Jones CD,Goode RL

更新日期：1981-04-01 00:00:00

abstract：:Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is...

journal_title：Molecular and cellular endocrinology

authors： Das SK,Balasubramanian P,Weerasekara YK

更新日期：2017-11-05 00:00:00

abstract：:Trophoblast cells produce several inmmuneregulators like the Vasoactive Intestinal Peptide (VIP) and P4 targeting multiple circuits, and also display an intese phagocytic ability allowing embryo implantation in a tolerogenic context. Here, we explored whether P4 and VIP- crosstalk modulates trophoblast cell function, ...

journal_title：Molecular and cellular endocrinology

authors： Vota D,Aguero M,Grasso E,Hauk V,Gallino L,Soczewski E,Pérez Leirós C,Ramhorst R

更新日期：2017-03-05 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily includes several closely related peptides including the activins and inhibins. Since we recently reported that TGF-beta 1 and beta 2 are potent inducers of steroid 5 alpha-reductase (5 alpha R), we have now studied the effects of these other peptides using pri...

journal_title：Molecular and cellular endocrinology

authors： Antonipillai I,Wahe M,Yamamoto J,Horton R

更新日期：1995-01-01 00:00:00

abstract：:Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-linked immunosorbent as...

journal_title：Molecular and cellular endocrinology

authors： Hockl P,Sorianello E,Chamson-Reig A,Ballerini G,Campo S,Groome N,Lux-Lantos V,Libertun C

更新日期：2003-05-30 00:00:00

abstract：:Clinical observations indicate that elevated aldosterone impairs cardiovascular function. The mechanisms, however, are not totally understood although total and cardiovascular mortality are decreased by aldosterone antagonists. Experimentally, increased plasma aldosterone induces pericoronary inflammation and cardiac ...

journal_title：Molecular and cellular endocrinology

authors： Heymes C,Garnier A,Fuchs S,Bendall JK,Nehme J,Ambroisine ML,Robidel E,Swynghedauw B,Milliez P,Delcayre C

更新日期：2004-03-31 00:00:00