11Beta-hydroxysteroid dehydrogenases in human endometrium.

abstract：:We examined the effects of growth hormone (GH), prolactin (PRL) and insulin-like growth factor-I (IGF-I) on DNA synthesis, and insulin-like growth factor binding protein 3 (IGFBP-3) gene expression, in a rat beta-cell line INS-1. GH and PRL were equally effective in increasing DNA synthesis and IGFBP-3 gene expression...

journal_title：Molecular and cellular endocrinology

authors： De W,Bréant B,Czernichow P,Asfari M

更新日期：1995-10-30 00:00:00

abstract：:MicroRNAs (miRNAs or miRs)-9 expression was reported to be upregulated in the follicular fluid of patients with polycystic ovary syndrome (PCOS). However, whether miR-9 affects ovarian dysfunction of PCOS and the related mechanisms are still unclear. Here we detected miR-9 and vitamin D receptor (VDR) expression in wo...

journal_title：Molecular and cellular endocrinology

authors： Kong F,Du C,Wang Y

更新日期：2019-04-15 00:00:00

abstract：:Catecholamines are known to have an inhibitory effect on oviductal smooth musculature by changing the adrenergic receptors activity. In order to further investigate the role of epinephrine and/or norepinephrine in oviduct, the distribution of beta-adrenergic receptors has been studied in the rat oviduct, using in vitr...

journal_title：Molecular and cellular endocrinology

authors： Tolszczuk M,Pelletier G

更新日期：1988-11-01 00:00:00

abstract：:Melatonin has repeatedly been shown to inhibit the proliferation of MCF-7 human breast cancer cells. Previous reports suggest that the actions of melatonin can be mediated either through G-protein coupled membrane receptors or via retinoid orphan receptors (RORalphas). In this study, we demonstrated the expression of ...

journal_title：Molecular and cellular endocrinology

authors： Dai J,Ram PT,Yuan L,Spriggs LL,Hill SM

更新日期：2001-05-15 00:00:00

abstract：:alpha-Fetoprotein (AFP) is a serum protein expressed during fetal life, the expression of which is shut off after birth. The activity of the mouse Afp gene promoter region comprised between -80 and -38 bp is regulated by the thyroid hormone receptor (T3R): negatively in the presence of T3 and positively in the absence...

journal_title：Molecular and cellular endocrinology

authors： Van Reeth T,Gabant P,Szpirer C,Szpirer J

更新日期：2002-02-25 00:00:00

abstract：:The role of cannabinoid receptor I (CBR-1) in the induction of decidualization was examined using decidual fibroblasts and human endometrial stromal cells as model systems. Decidual fibroblasts decidualized in vitro for 3 and 6 days in the presence of the CBR-1 agonist R(+)-WIN 55,212-2 mesylate (WIN, 0.1-10 microM) e...

journal_title：Molecular and cellular endocrinology

authors： Moghadam KK,Kessler CA,Schroeder JK,Buckley AR,Brar AK,Handwerger S

更新日期：2005-01-14 00:00:00

abstract：:Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-k...

journal_title：Molecular and cellular endocrinology

authors： Kuil CW,Mulder E

更新日期：1994-06-01 00:00:00

abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

journal_title：Molecular and cellular endocrinology

authors： Chun TY,Bloem L,Pratt JH

更新日期：2002-08-30 00:00:00

abstract：:Temperature-dependent sex determination (TSD) is a prime example of phenotypic plasticity in that gonadal sex is determined by the temperature of the incubating egg. In the red-eared slider turtle (Trachemys scripta), the effect of temperature can be overridden by exogenous ligands, i.e., sex steroid hormones and ster...

journal_title：Molecular and cellular endocrinology

authors： Matsumoto Y,Crews D

更新日期：2012-05-06 00:00:00

abstract：:Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], a...

journal_title：Molecular and cellular endocrinology

authors： Pathak V,Gault VA,Flatt PR,Irwin N

更新日期：2015-02-05 00:00:00

abstract：:The expression of prostatic acid phosphatase (PAcP) in three human prostate carcinoma cell lines including LNCaP, DU 145 and PC-3, was studied to explore its potential role as a marker in the progression of prostate cancer. Although Southern blot analysis suggested the presence of PAcP gene in all three prostate carci...

journal_title：Molecular and cellular endocrinology

authors： Garcia-Arenas R,Lin FF,Lin D,Jin LP,Shih CC,Chang C,Lin MF

更新日期：1995-04-28 00:00:00

abstract：:The cell line MD-IGF-1, containing an ovine IGF-1 cDNA driven by the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter, was used to study expression of IGF-1 linked to the MMTV-LTR in bovine mammary epithelial cells in response to various hormonal and substratum stimuli. Acute sensitivity of the MMTV-...

journal_title：Molecular and cellular endocrinology

authors： Romagnolo D,Akers RM,Wong EA,Boyle PL,McFadden TB,Byatt JC,Turner JD

更新日期：1993-10-01 00:00:00

abstract：:Polyamines are well-known ubiquitous components of living cells. Although these polycations have been implicated in the regulation of major cellular functions such as DNA, RNA and protein synthesis occurring during cellular proliferation and/or differentiation processes, their mechanism of action at the molecular leve...

journal_title：Molecular and cellular endocrinology

authors： Cochet C,Chambaz EM

更新日期：1983-06-01 00:00:00

abstract：:Cannabinoids, the main active components of marijuana, have been shown to exert different adverse effects on male reproduction both in vertebrates and invertebrates. The main effects of endocannabinoids, a particular group of endogenously produced cannabinoids, in sperm are the inhibition of motility, capacitation and...

journal_title：Molecular and cellular endocrinology

authors： Rossato M

更新日期：2008-04-16 00:00:00

abstract：:Exploitation of estrogen's vasculoprotective properties in drug design is difficult due to its adverse effects on endometrium and breast. Selective estrogen receptor modulators (SERM) act as estrogen agonists in some tissues but are anti-estrogenic in others. We investigate here whether tamoxifen, raloxifene, and two ...

journal_title：Molecular and cellular endocrinology

authors： Savolainen-Peltonen H,Luoto NM,Kangas L,Häyry P

更新日期：2004-11-30 00:00:00

abstract：:We have used plus-minus hybridization to identify Xenopus liver cDNA clones of mRNAs whose levels are regulated by estrogen. One clone identified in this way was shown to be a nearly full-length cDNA clone of the mRNA coding for a small 22 000 dalton estrogen-inducible serum protein (EISP). Quantitation of EISP mRNA l...

journal_title：Molecular and cellular endocrinology

authors： Hayward MA,Barton MC,Shapiro DJ

更新日期：1985-02-01 00:00:00

abstract：:The regulation of the insulin receptor by cAMP has been examined in glial C6 cells. Incubation for 48 h with dibutyryl cyclic AMP produced a dose-dependent inhibition of 125I-insulin binding to the cells. Other agents that elevate intracellular cAMP levels such as forskolin and cholera toxin mimicked the effect of thi...

journal_title：Molecular and cellular endocrinology

authors： Montiel F,Aranda A,Pascual A

更新日期：1989-02-01 00:00:00

abstract：:Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in...

journal_title：Molecular and cellular endocrinology

authors： Lammel Lindemann JA,Angajala A,Engler DA,Webb P,Ayers SD

更新日期：2014-05-05 00:00:00

abstract：:Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular ...

journal_title：Molecular and cellular endocrinology

authors： Chopin L,Walpole C,Seim I,Cunningham P,Murray R,Whiteside E,Josh P,Herington A

更新日期：2011-06-20 00:00:00

abstract：:The in vitro secretion of immunoreactive somatomedin C/insulin-like growth factor I (IR Sm-C/IGF-I) by two human breast cancer cell lines, MCF-7 and EVSA-T has been studied. IR Sm-C/IGF-I concentration showed a linear increase in serum-free culture media over 72 h of incubation for both cell lines, and a close correla...

journal_title：Molecular and cellular endocrinology

authors： Minuto F,Del Monte P,Barreca A,Nicolin A,Giordano G

更新日期：1987-12-01 00:00:00

abstract：:We investigated the involvement of protein synthesis in the stimulatory action of thyroid hormones on amino acid accumulation and characterized K(+) currents involved in the hyperpolarizing effect of thyroxine (T(4)) on Sertoli cells. Immature rat testes were incubated in Krebs Ringer-bicarbonate buffer (KRb) in the p...

journal_title：Molecular and cellular endocrinology

authors： Menegaz D,Zamoner A,Royer C,Leite LD,Bortolotto ZA,Silva FR

更新日期：2006-02-26 00:00:00

abstract：:Differentiation of human placental mononuclear trophoblasts into a multinucleate syncytium involves up-regulation of key proteins promoting cell fusion and increased capacity for placental hormonogenesis. It is well established that the activation of adenylyl cyclase leads to increased expression of trophoblast fusoge...

journal_title：Molecular and cellular endocrinology

authors： Delidaki M,Gu M,Hein A,Vatish M,Grammatopoulos DK

更新日期：2011-01-30 00:00:00

abstract：:We examined the effect of growth hormone on local growth factor mRNA expression in male Sprague-Dawley rats. Repetitive systemic administration of growth hormone (0.4 IU every 4 h) increased the expression of IGF-I mRNA up to 2.8-fold in costal cartilage tissue compared with controls. Basic FGF (bFGF) mRNA expression ...

journal_title：Molecular and cellular endocrinology

authors： Izumi T,Shida J,Jingushi S,Hotokebuchi T,Sugioka Y

更新日期：1995-07-01 00:00:00

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:Men have had a substantially higher risk of developing bladder cancer than women. This has prompted research on androgen-mediated androgen receptor (AR) signaling in urothelial cancer. Indeed, increasing preclinical evidence indicates that AR activation correlates with the promotion of urothelial carcinogenesis and tu...

journal_title：Molecular and cellular endocrinology

authors： Inoue S,Mizushima T,Miyamoto H

更新日期：2018-04-15 00:00:00

abstract：:Insulin stimulates rapid tyrosine phosphorylation of the protein Shc, which subsequently binds to Grb2, resulting in the activation of a complex mitogenic signaling network. In this study, we examined the levels of Shc protein, its phosphorylation state and Shc-Grb2 association in liver, muscle and adipose tissue befo...

journal_title：Molecular and cellular endocrinology

authors： Páez-Espinosa EV,Rocha EM,Velloso LA,Boschero AC,Saad MJ

更新日期：1999-10-25 00:00:00

abstract：:Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism (CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been investigated. Here we conducted a genetic screening of TG gene in a cohort of 382 Chinese CH patients. We identified 22 rare non-polymorphic v...

journal_title：Molecular and cellular endocrinology

authors： Hu X,Chen R,Fu C,Fan X,Wang J,Qian J,Yi S,Li C,Luo J,Su J,Zhang S,Xie B,Zheng H,Lai Y,Chen Y,Li H,Gu X,Chen S,Shen Y

更新日期：2016-03-05 00:00:00

abstract：:The screening of an oligo(dT)-primed prostate cDNA library with a human glandular kallikrein-1 (hGK-1) genomic DNA fragment resulted in the isolation of two different hGK-1 cDNAs. A 1.2 kb cDNA (pGK-1) contains an open reading frame of 510 bp, encoding the major part of the previously predicted hGK-1 protein (Schedlic...

journal_title：Molecular and cellular endocrinology

authors： Riegman PH,Vlietstra RJ,van der Korput HA,Romijn JC,Trapman J

更新日期：1991-04-01 00:00:00

abstract：:Cyclic ewes were treated with control vehicle or progesterone receptor antagonist (onapristone; 100mg i.m. twice daily) during either early (day 3-5) or late (day 12-14) luteal phase and plasma samples collected for hormone analysis and to determine endogenous and oxytocin induced PGF2α release. On day 14 and 17, ewes...

journal_title：Molecular and cellular endocrinology

authors： Mann GE,Wathes DC,Robinson RS

更新日期：2013-08-25 00:00:00

abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

journal_title：Molecular and cellular endocrinology

authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

更新日期：2019-01-15 00:00:00