Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells.

abstract：:The high mobility group AT-hook (HMGA) proteins, a family of DNA architectural factors, are highly expressed during embryogenesis and play a crucial role in several different biological processes, as well as in tumorigenesis of a wide range of tissues, including pituitary. Indeed, HMGA2 has been found rearranged and a...

journal_title：Molecular and cellular endocrinology

authors： Fedele M,Palmieri D,Fusco A

更新日期：2010-09-15 00:00:00

abstract：:The age-related evolution of the in vitro effects of a gonadotropin releasing hormone agonist ([D-Trp6]-GnRH) on the secretion of testosterone by the testis, cultured during 3 days on a Millipore filter floating on M199 medium, was studied during the perinatal period in the rat. The basal and luteinizing hormone (LH)-...

journal_title：Molecular and cellular endocrinology

authors： Habert R,Devif I,Gangnerau MN,Lecerf L

更新日期：1991-12-01 00:00:00

abstract：:The distribution and molecular forms of bombesin-like immunoreactivity (BLI) were determined in the ovine median eminence using a new, C-terminally directed antiserum. BLI was confined to neurons of the external zone of the median eminence, near small blood vessels, many of which also were immunoreactive for CRF. Each...

journal_title：Molecular and cellular endocrinology

authors： Giraud AS,Smith AI,Rundle SE

更新日期：1987-10-01 00:00:00

abstract：:The expression of genes encoding inhibin/activin subunits and activin receptor was examined in four cultured Leydig tumor cells (MA-10, I-10, R2C, and LC-540). Inhibin alpha-subunit gene was highly expressed in Leydig tumor cell lines except LC-540. Both inhibin beta-A- and beta-B-subunit mRNAs were present in low lev...

journal_title：Molecular and cellular endocrinology

authors： Chen CL,Pignataro OP,Feng ZM

更新日期：1993-07-01 00:00:00

abstract：:Findings concerning the role of diabetes mellitus (DM) in osteoclast differentiation are contradictory in vivo and in vitro. Sirtuin 1 (SIRT1) can inhibit RANKL-induced osteoclastogenesis and deacetylate p66Shc suppress its phosphorylation in high glucose (HG)-stimulated human umbilical vein endothelial cells. This st...

journal_title：Molecular and cellular endocrinology

authors： Qu B,Gong K,Yang H,Li Y,Jiang T,Zeng Z,Cao Z,Pan X

更新日期：2018-10-15 00:00:00

abstract：:Oxytocin (OT) plays an important role in the onset of human labour by stimulating uterine contractions and promoting prostaglandin/inflammatory cytokine synthesis in amnion via oxytocin receptor (OTR) coupling. The OTR-antagonist, Atosiban, is widely used as a tocolytic for the management of acute preterm labour. We f...

journal_title：Molecular and cellular endocrinology

authors： Kim SH,MacIntyre DA,Hanyaloglu AC,Blanks AM,Thornton S,Bennett PR,Terzidou V

更新日期：2016-01-15 00:00:00

abstract：:Activins play a fundamental role in cell differentiation and development. Activin A signaling is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated. Here, we found that activin AB and activi...

journal_title：Molecular and cellular endocrinology

authors： Tsuchida K,Nakatani M,Yamakawa N,Hashimoto O,Hasegawa Y,Sugino H

更新日期：2004-05-31 00:00:00

abstract：:Testosterone is converted to the more biologically active androgen, dihydrotestosterone (DHT), by steroid 5alpha-reductase. Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spe...

journal_title：Molecular and cellular endocrinology

authors： Robaire B,Henderson NA

更新日期：2006-05-16 00:00:00

abstract：:The effect of a gonadotropin-releasing hormone-agonist (GnRH-a) on the synthesis of insulin-like growth factor-binding protein-5 (IGFBP-5), a physiological marker for atresia, was investigated. Granulosa cells obtained from diethylstilbestrol (DES)-treated immature female rats were cultured in serum-free medium for 72...

journal_title：Molecular and cellular endocrinology

authors： Onoda N,Li D,Mickey G,Erickson G,Shimasaki S

更新日期：1995-04-28 00:00:00

abstract：:Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ isoform that contains two nuclear recep...

journal_title：Molecular and cellular endocrinology

authors： Snyder CA,Goodson ML,Schroeder AC,Privalsky ML

更新日期：2015-09-15 00:00:00

abstract：:After the luteinizing hormone (LH) surge, the cells that remain from the ovulated follicle undergo a process of differentiation termed luteinization. Two key features of the cells after luteinization are the capacity for tremendous production of progesterone [10(16) molecules of progesterone per (min/(g of CL))] and t...

journal_title：Molecular and cellular endocrinology

authors： Diaz FJ,Anderson LE,Wu YL,Rabot A,Tsai SJ,Wiltbank MC

更新日期：2002-05-31 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which whe...

journal_title：Molecular and cellular endocrinology

authors： Drummond AE,Dyson M,Le MT,Ethier JF,Findlay JK

更新日期：2003-04-28 00:00:00

abstract：:The study aims to examine the effects of restraint, cold, and in combination of hypoxia on pituitary GH mRNA and hepatic IGF-I mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (CRFR1) and SS in mediating the effects of continual hypoxia. Continual or inte...

journal_title：Molecular and cellular endocrinology

authors： Chen XQ,Xu NY,Du JZ,Wang Y,Duan C

更新日期：2005-10-20 00:00:00

abstract：:Specific binding sites for bovine placental lactogen (bPL) and the lactogenic hormone, prolactin, have been detected in endometrial membranes isolated from uteri of mid-pregnant heifers. The specific binding of human growth hormone (hGH) (used to monitor the presence of lactogenic binding sites) and of bPL was increas...

journal_title：Molecular and cellular endocrinology

authors： Galosy SS,Gertler A,Elberg G,Laird DM

更新日期：1991-07-01 00:00:00

abstract：:Growth hormone (GH) secretion, evoked by either pituitary adenylate cyclase-activating polypeptide (PACAP) or dopamine (DA), is dependent on both voltage-sensitive calcium channels (VSCC) and cAMP signaling in goldfish. We further characterized the involvement of Ca2+ in evoked release by PACAP and DA, by examining th...

journal_title：Molecular and cellular endocrinology

authors： Chang JP,Wong CJ,Davis PJ,Soetaert B,Fedorow C,Sawisky G

更新日期：2003-08-29 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent isolated from Androgr...

journal_title：Molecular and cellular endocrinology

authors： Zhang M,Yang M,Wang N,Liu Q,Wang B,Huang T,Tong Y,Ming Y,Wong CW,Liu J,Yao D,Guan M

更新日期：2020-08-01 00:00:00

abstract：:Patients with PS or non-syndromic deafness were submitted to genetic/functional analyzes of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator FOXI1, and of the potassium channel KCNJ10. SLC26A4 was the most frequently mutated gene. An altered intracellular localization with immunocyt...

journal_title：Molecular and cellular endocrinology

authors： Cirello V,Bazzini C,Vezzoli V,Muzza M,Rodighiero S,Castorina P,Maffini A,Bottà G,Persani L,Beck-Peccoz P,Meyer G,Fugazzola L

更新日期：2012-04-04 00:00:00

abstract：:Employing RT- and RACE-PCR on RNA isolated from testicular tissue, we have cloned the coding cDNA sequence for the RLF, also known as Insl3, of the fallow deer. The RLF coding sequence consisted of 396 bp encoding a peptide of 131 amino acids and shared highest homology with bovine, sheep and goat RLF. Northern analys...

journal_title：Molecular and cellular endocrinology

authors： Hombach-Klonisch S,Kauffold J,Rautenberg T,Steger K,Tetens F,Fischer B,Klonisch T

更新日期：2000-01-25 00:00:00

abstract：:The effect of thyroid status on the postnatal development of the two molecular forms of Na+,K+-ATPase, distinguished kinetically on the basis of their ouabain sensitivity, was examined in rat brain. Hypothyroidism induced by PTU from day 1 postnatally significantly reduced the Na+,K+-ATPase activity in cerebellum (22-...

journal_title：Molecular and cellular endocrinology

authors： Atterwill CK,Reid J,Athayde CM

更新日期：1985-05-01 00:00:00

abstract：:Nuclear Receptors form a superfamily of 48 transcription factors that exhibit a plethora of functions in steroid hormone signaling, regulation of metabolism, circadian rhythm and cellular differentiation. In this review, we describe our current knowledge on the role of Nuclear Receptors in atherosclerosis, which is a ...

journal_title：Molecular and cellular endocrinology

authors： Kurakula K,Hamers AA,de Waard V,de Vries CJ

更新日期：2013-04-10 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) protects the non-discriminating mineralocorticoid receptor from occupation by glucocorticoids. In man the enzyme is also highly expressed in the placenta where it is thought to also protect the fetus from the high circulating levels of maternal glu...

journal_title：Molecular and cellular endocrinology

authors： Li KX,Smith RE,Ferrari P,Funder JW,Krozowski ZS

更新日期：1996-06-18 00:00:00

abstract：:We reported previously that stem Leydig cells (SLC) on the surfaces of rat testicular seminiferous tubules are able to differentiate into Leydig cells. The proliferation and differentiation of SLCs seem likely to be regulated by niche cells, including nearby germ and Sertoli cells. Due to the cyclical nature of sperma...

journal_title：Molecular and cellular endocrinology

authors： Guan X,Chen F,Chen P,Zhao X,Mei H,Liu J,Lian Q,Zirkin BR,Chen H

更新日期：2019-02-05 00:00:00

abstract：:Type I pseudohypoaldosteronism (PHA1) is a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting and failure to thrive. Typical biochemical features include high levels of plasma aldosterone and renin, hyponatremia and hyperkalemia. Different mutations of the human mineralocorticoid re...

journal_title：Molecular and cellular endocrinology

authors： Sartorato P,Khaldi Y,Lapeyraque AL,Armanini D,Kuhnle U,Salomon R,Caprio M,Viengchareun S,Lombès M,Zennaro MC

更新日期：2004-03-31 00:00:00

abstract：:The mechanisms that control the onset of puberty remain within the purview of the neurobiologists who first recognised the concept of removal of a restraint factor to permit reawakening of puberty. The discovery of a ligand-activated G protein receptor-signalling pathway upstream of the GnRH pulse generator adds furth...

journal_title：Molecular and cellular endocrinology

authors： Hughes IA,Kumanan M

更新日期：2006-07-25 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity. We investigated whether in vitro, adipocyte SSAO was mo...

journal_title：Molecular and cellular endocrinology

authors： Repessé X,Moldes M,Muscat A,Vatier C,Chetrite G,Gille T,Planes C,Filip A,Mercier N,Duranteau J,Fève B

更新日期：2015-08-15 00:00:00

abstract：:Factors that regulate the tissue specific and developmental expression of the GLUT4 gene, whose transcribed protein is primarily responsible for mediating insulin stimulated glucose transport, are poorly defined. In this study we examined the effects of retinoic acid, a circulating factor that can promote cellular dif...

journal_title：Molecular and cellular endocrinology

authors： Sleeman MW,Zhou H,Rogers S,Ng KW,Best JD

更新日期：1995-02-27 00:00:00

abstract：:In an effort to identify the signal transduction mechanism associated with the inhibition of juvenile hormone (JH) biosynthesis by the neuropeptides allatostatins, levels of the cyclic nucleotides cAMP and cGMP were measured in corpora allata (CA) of virgin and mated Diploptera punctata females using radioimmunoassays...

journal_title：Molecular and cellular endocrinology

authors： Cusson M,Yagi KJ,Guan XC,Tobe SS

更新日期：1992-11-01 00:00:00

abstract：:Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G(1)-S phase cell cycle progression. We investigated this cooperativity by evaluating if the key cell cycle regulators, c-Myc and cyclin D1, represent points of conv...

journal_title：Molecular and cellular endocrinology

authors： Mawson A,Lai A,Carroll JS,Sergio CM,Mitchell CJ,Sarcevic B

更新日期：2005-01-14 00:00:00

abstract：:Allatostatins with a typical YXFGL-amide C-terminus constitute a neuropeptide family, which was discovered because of its inhibitory action on insect juvenile hormone synthesis. In the search for possible new functions for allatostatins we focused our attention on the fat body. Our previous studies on the cockroach Bl...

journal_title：Molecular and cellular endocrinology

authors： Martín D,Piulachs MD,Bellés X

更新日期：1996-08-09 00:00:00