Abstract:
:Testosterone is converted to the more biologically active androgen, dihydrotestosterone (DHT), by steroid 5alpha-reductase. Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa. Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation. Several compounds have been reported to inhibit either one or both forms of 5alpha-reductase in many tissues. The first commercially available inhibitor of 5alpha-reductase, finasteride, has a predominant effect on the type 2 isozyme, while more recently developed agents, such as dutasteride, PNU157706 and FK143, act as dual inhibitors. We found that the treatment of adult rats with such agents results in pronounced effects on the expression of genes essential to the formation of the optimal luminal microenvironment that is required for proper sperm maturation. Furthermore, drug treatment caused a significant decrease in the percentage of progressively motile and morphologically normal spermatozoa in the cauda epididymides. Mating females to treated males resulted in fewer successful pregnancies and a higher rate of pre-implantation loss. Thus, there may be a role for dual 5alpha-reductase inhibitors as potential components of a male contraceptive.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Robaire B,Henderson NAdoi
10.1016/j.mce.2005.12.044keywords:
subject
Has Abstractpub_date
2006-05-16 00:00:00pages
190-5issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(05)00490-9journal_volume
250pub_type
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
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pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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更新日期:2014-07-05 00:00:00
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更新日期:2000-04-25 00:00:00
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pub_type: 杂志文章
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