Relaxin-like factor (RLF) mRNA expression in the fallow deer.

abstract：:Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G(1)-S phase cell cycle progression. We investigated this cooperativity by evaluating if the key cell cycle regulators, c-Myc and cyclin D1, represent points of conv...

journal_title：Molecular and cellular endocrinology

authors： Mawson A,Lai A,Carroll JS,Sergio CM,Mitchell CJ,Sarcevic B

更新日期：2005-01-14 00:00:00

abstract：:If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the in...

journal_title：Molecular and cellular endocrinology

authors： Delvenne P,Herman L,Kholod N,Caberg JH,Herfs M,Boniver J,Jacobs N,Hubert P

更新日期：2007-01-29 00:00:00

abstract：:Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse subma...

journal_title：Molecular and cellular endocrinology

authors： Ludwig G,Ganten D,Murakami K,Fasching U,Hackenthal E

更新日期：1987-04-01 00:00:00

abstract：:The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms....

journal_title：Molecular and cellular endocrinology

authors： Taylor JA,Lewis KJ,Lubahn DB

更新日期：1998-10-25 00:00:00

abstract：:The aim of this study was to evaluate the episodic-like memory (ELM) and the transcriptional regulation of the enzymes involved in hippocampal allopregnanolone synthesis in young adult and middle-aged male and female rats. Young adult males, but not middle-aged ones, showed a good performance in the ELM task. In contr...

journal_title：Molecular and cellular endocrinology

authors： Rossetti MF,Varayoud J,Andreoli MF,Stoker C,Luque EH,Ramos JG

更新日期：2018-07-15 00:00:00

abstract：:Recent findings demonstrated that a subset of papillary thyroid cancers (PTCs) is characterized by reduced expression of the von Hippel-Lindau (VHL) tumor suppressor gene, and that lowest levels associated with more aggressive PTCs. In the present study, the levels of the two VHL mRNA splicing variants, VHL-213 (V1) a...

journal_title：Molecular and cellular endocrinology

authors： Baldini E,Tuccilli C,Arlot-Bonnemains Y,Chesnel F,Sorrenti S,De Vito C,Catania A,D'Armiento E,Antonelli A,Fallahi P,Watutantrige-Fernando S,Tartaglia F,Barollo S,Mian C,Bononi M,Arceri S,Mascagni D,Vergine M,Pironi D

更新日期：2017-03-05 00:00:00

abstract：:The chum salmon insulin-like growth factor II (IGF-II) gene is highly expressed in liver tissue. In this study we demonstrate that two transcription factors, Sp1 and C/EBPbeta, are involved in the enhanced expression of the salmon IGF-II gene. The presence of the fish homolog for C/EBPbeta in salmon liver RNA was conf...

journal_title：Molecular and cellular endocrinology

authors： Palamarchuk AY,Kavsan VM,Sussenbach JS,Holthuizen PE

更新日期：2001-02-14 00:00:00

abstract：:Microcirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and preven...

journal_title：Molecular and cellular endocrinology

authors： Herrera NA,Duchatsch F,Tardelli LP,Dionísio TJ,Shinohara AL,Santos CF,Amaral SL

更新日期：2020-04-05 00:00:00

abstract：:The screening of an oligo(dT)-primed prostate cDNA library with a human glandular kallikrein-1 (hGK-1) genomic DNA fragment resulted in the isolation of two different hGK-1 cDNAs. A 1.2 kb cDNA (pGK-1) contains an open reading frame of 510 bp, encoding the major part of the previously predicted hGK-1 protein (Schedlic...

journal_title：Molecular and cellular endocrinology

authors： Riegman PH,Vlietstra RJ,van der Korput HA,Romijn JC,Trapman J

更新日期：1991-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR α and PPAR β/δ activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742-pharmacological activators of PPAR ...

journal_title：Molecular and cellular endocrinology

authors： Regueira M,Riera MF,Galardo MN,Pellizzari EH,Cigorraga SB,Meroni SB

更新日期：2014-01-25 00:00:00

abstract：:The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR g...

journal_title：Molecular and cellular endocrinology

authors： Henrohn D,Le Grevés P,Nyberg F

更新日期：1997-12-12 00:00:00

abstract：:The NAD+ dependent (K or type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase oxidizes glucocorticoids and thus prevents them from occupying mineralocorticoid receptors. Mutations in the HSD11K (HSD11B2) gene encoding this isozyme cause a genetic form of hypertension, the syndrome of apparent mineralocorticoid exce...

journal_title：Molecular and cellular endocrinology

authors： Agarwal AK,White PC

更新日期：1996-07-23 00:00:00

abstract：:We report a novel method to study the mechanisms of luteinizing hormone (LH) receptor desensitization and truncation, using antisense oligodeoxynucleotides that code for regions of the NH2-terminus, the third extracellular loop and the C-terminus of the LH receptor. Mouse tumour (MA10) Leydig cells were incubated for ...

journal_title：Molecular and cellular endocrinology

authors： West AP,Cooke BA

更新日期：1991-08-01 00:00:00

abstract：:Transforming growth factor beta (TGF beta) caused a dose-dependent increase in both basal and follicle-stimulating hormone (FSH)-stimulated inhibin production by rat granulosa cells in culture. The TGF beta dose-response curve in the absence of FSH was approximately parallel to that in the presence of either a minimal...

journal_title：Molecular and cellular endocrinology

authors： Zhang ZW,Findlay JK,Carson RS,Herington AC,Burger HG

更新日期：1988-08-01 00:00:00

abstract：:When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accum...

journal_title：Molecular and cellular endocrinology

authors： Verhoeven G,Cailleau J,de Moor P

更新日期：1980-11-01 00:00:00

abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

journal_title：Molecular and cellular endocrinology

authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

更新日期：1987-12-01 00:00:00

abstract：:The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells with growth hormone in vitro. All cells in thymus were not found to be sensitive to the hormone. The proportion of cells whose surface charge was altered by the hormone was 65% in the thymocytes from 5-week-old rats. T...

journal_title：Molecular and cellular endocrinology

authors： Hanjan SN,Talwar GP

更新日期：1975-09-01 00:00:00

abstract：:A new analogue of recombinant human growth hormone (hGH), hGH des(1-6,14) was expressed in Escherichia coli, refolded and purified to homogeneity. The mutation decreased the hormone's ability to bind lactogenic and somatogenic receptors through its site 1, and almost completely abolished its ability to bind these rece...

journal_title：Molecular and cellular endocrinology

authors： Tchelet A,Vogel T,Helman D,Guy R,Neospouolus C,Goffin V,Djiane J,Gertler A

更新日期：1997-06-20 00:00:00

abstract：:The gene encoding ovine 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) was cloned and characterized. This gene consists of five exons and is greater than 4 kb in length. It contains an open reading frame of 1215 bp, which encodes a protein of 404 amino acids with a predicted MW of 44 kDa. The deduced ovine...

journal_title：Molecular and cellular endocrinology

authors： Campbell LE,Yu M,Yang K

更新日期：1996-05-17 00:00:00

abstract：:This study examines the effect of FSH, testosterone and estradiol on testicular LH receptors and in vitro testicular responsiveness to LH in immature rats under various conditions. FSH treatment of 15-day-old immature rats significantly increased the number of LH receptors but did not alter testicular responsiveness. ...

journal_title：Molecular and cellular endocrinology

authors： Chen YD,Shaw MJ,Payne AH

更新日期：1977-10-01 00:00:00

abstract：:Skeletal muscle is the major site of postprandial glucose disposal and augmenting glucose uptake into this tissue may attenuate insulin resistance that precedes type 2 diabetes mellitus. Here, we investigated the effect of pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and...

journal_title：Molecular and cellular endocrinology

authors： Tamrakar AK,Jaiswal N,Yadav PP,Maurya R,Srivastava AK

更新日期：2011-06-06 00:00:00

abstract：:Glucose uptake by brown adipose tissue, measured following deoxyglucose injection in vivo, was increased by 6- and 11-fold following 2 and 14 days of cold exposure, respectively. To look for the possible mechanism of these modifications, the glucose transporter Glut 4 has been characterized at the protein and mRNA lev...

journal_title：Molecular and cellular endocrinology

authors： Olichon-Berthe C,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1992-11-01 00:00:00

abstract：:Dispersed, estradiol (E2)-treated, rat pituitary cell cultures were used to examine the intracellular processing of progesterone (P) associated with its modulation of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretion. Enhancement and suppression of LH release was only observed with ac...

journal_title：Molecular and cellular endocrinology

authors： Krey LC,Kamel F,MacLusky NJ

更新日期：1990-01-22 00:00:00

abstract：:The aim of this study was to investigate whether co-culture of human islets with adipose-derived stem cells (ASCs) can improve islet quality and to evaluate which factors play a role in the protective effect of ASCs against islet dysfunction. Islets and ASCs were cultured in three experimental groups for 24 h, 48 h, a...

journal_title：Molecular and cellular endocrinology

authors： de Souza BM,Rodrigues M,de Oliveira FS,da Silva LPA,Bouças AP,Portinho CP,Dos Santos BP,Camassola M,Rocha D,Lysakowski S,Martini J,Leitão CB,Nardi NB,Bauer AC,Crispim D

更新日期：2020-04-05 00:00:00

abstract：:Calcium salts were found to replace ACTH in inducing steroidogenesis in isolated adrenocortical cells from rats. This Ca-specific stimulation occurred when the cation was presented to the cells in the presence of phosphate and carbonate as a counter-ions under conditions which favoured the formation of colloidal calci...

journal_title：Molecular and cellular endocrinology

authors： Neher R,Milani A

更新日期：1978-01-01 00:00:00

abstract：:Thyroid dysgenesis is the most frequent cause of congenital hypothyroidism, but its molecular pathophysiology is largely unknown. Our hypothesis that some genes downstream to thyroid transcription factor-2 (TTF-2) might be responsible for development of the thyroid prompted us to identify genes whose expression is sti...

journal_title：Molecular and cellular endocrinology

authors： Hishinuma A,Ohmika N,Namatame T,Ieiri T

更新日期：2004-06-30 00:00:00

abstract：:The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes. Important in this relationship is the strong correlation between hyperinsulinemia and low levels of albuminuria (e.g. microalbuminuria). Recent work highl...

journal_title：Molecular and cellular endocrinology

authors： Nistala R,Whaley-Connell A

更新日期：2013-09-25 00:00:00

abstract：:The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial i...

journal_title：Molecular and cellular endocrinology

authors： Castillo AF,Orlando U,Helfenberger KE,Poderoso C,Podesta EJ

更新日期：2015-06-15 00:00:00

abstract：:The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for thei...

journal_title：Molecular and cellular endocrinology

authors： Cooray SN,Clark AJ

更新日期：2011-01-15 00:00:00

abstract：:Recently, a remarkable progress has been made in our understanding about the role of sex steroids in male physiology. In this paper, we consider the clinical aspects of congenital estrogen deficiency - notably, estrogen resistance and aromatase deficiency - in men and we discuss both well-established and supposed estr...

journal_title：Molecular and cellular endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Baraldi E,Faustini-Fustini M,Granata AR,Carani C

更新日期：2001-06-10 00:00:00