Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.

abstract：:This work was designed to determine whether IGF-1 and EGF modulate nuclear transfer and transactivation of the androgen receptor (AR) in human prostate cell lines (PNT1A and DU-145). We first characterized the IGF-1 and EGF receptors by ligand-binding assays with [125I] IGF-1 and [125I] EGF in a normal human prostate ...

journal_title：Molecular and cellular endocrinology

authors： Orio F Jr,Térouanne B,Georget V,Lumbroso S,Avances C,Siatka C,Sultan C

更新日期：2002-12-30 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:In previous studies, we found that endometriotic stromal cells lose the ability to regulate cell survival signaling in endometriotic epithelial cells. Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved. We found that ecto...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Xue J,Li M,Zhao X,Wei D,Li C

更新日期：2015-09-15 00:00:00

abstract：:Extracts from the plant Pygeum africanum are widely used in the therapy of benign prostate hyperplasia (BPH) and in combinational therapy for prostate cancer, the second leading cause of cancer death and the mostly diagnosed form of cancer in men. The androgen receptor (AR) plays a crucial role in the development of t...

journal_title：Molecular and cellular endocrinology

authors： Roell D,Baniahmad A

更新日期：2011-01-30 00:00:00

abstract：:We reported previously that stem Leydig cells (SLC) on the surfaces of rat testicular seminiferous tubules are able to differentiate into Leydig cells. The proliferation and differentiation of SLCs seem likely to be regulated by niche cells, including nearby germ and Sertoli cells. Due to the cyclical nature of sperma...

journal_title：Molecular and cellular endocrinology

authors： Guan X,Chen F,Chen P,Zhao X,Mei H,Liu J,Lian Q,Zirkin BR,Chen H

更新日期：2019-02-05 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily includes several closely related peptides including the activins and inhibins. Since we recently reported that TGF-beta 1 and beta 2 are potent inducers of steroid 5 alpha-reductase (5 alpha R), we have now studied the effects of these other peptides using pri...

journal_title：Molecular and cellular endocrinology

authors： Antonipillai I,Wahe M,Yamamoto J,Horton R

更新日期：1995-01-01 00:00:00

abstract：:Sox genes participate in several developmental processes, including sex determination and differentiation. In this study, the genomic structure of sox17 was characterized in the sea bass (sb). Two transcripts, one producing a normal protein (sb Sox17) and another producing a truncated protein (sb t-Sox17) were detecte...

journal_title：Molecular and cellular endocrinology

authors： Navarro-Martín L,Galay-Burgos M,Sweeney G,Piferrer F

更新日期：2009-02-27 00:00:00

abstract：:The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three...

journal_title：Molecular and cellular endocrinology

authors： Qi H,Grenier J,Fournier A,Labrie C

更新日期：2003-11-28 00:00:00

abstract：:This study examines the effect of preincubation of sheep ovarian follicles with hCG or FSH on the ability of isolated theca and granulosa to increase cAMP levels in response to a second incubation with hCG or FSH. Secondly, the effect of preincubation of small follicles with hCG on androstenedione and testosterone pro...

journal_title：Molecular and cellular endocrinology

authors： Weiss TJ,Armstrong DT

更新日期：1979-03-01 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:A comparative study of hGH and IL2 post-signaling effects, as examined by RNA expression (Nb29) and protein levels of the heat-shock protein hsp70, was performed in a hormone-dependent rat lymphoma cell line, Nb2-11C. Optimal doses of hGH or IL2 increased Nb29 expression in a dose-dependent manner. Addition of both mi...

journal_title：Molecular and cellular endocrinology

authors： Horn S,Cohen R,Gertler A

更新日期：1994-11-01 00:00:00

abstract：:The effects of cholera toxin on the responses of cultured Sertoli cells were compared with those elicited by follicle-stimulating hormone (FSH), and N6O2'-dibutyryl-3',5'-cyclic AMP (bu2cAMP). Addition of FSH or cholera toxin increased cAMP levels. Subsequently there was greater rates of conversion of testosterone to ...

journal_title：Molecular and cellular endocrinology

authors： Fritz IB,Griswold MD,Louis BG,Dorrington JH

更新日期：1976-08-01 00:00:00

abstract：:An enzyme system capable of monodeiodinating T4 to T3 and to rT3 in a microsomal fraction of normal human thyroid tissue is characterized. The pH optimum for 5'-monodeiodination of T4 to T3 was around 7.0 The Km (apparent) for the conversion of T4 to T3 was 5.7 mumoles/l. PTU, ipodate and rT3 inhibited T4 deiodination...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P

更新日期：1984-10-01 00:00:00

abstract：:As deduced on the basis of cloning experiments, the putative extracellular domain of pituitary glycoprotein hormone (lutropin (LH), thyrotropin (TSH), and FSH) receptors (rec) is sufficiently large to suggest involvement in hormone binding. Comparison of the amino acid sequences of the extracellular domains of the gly...

journal_title：Molecular and cellular endocrinology

authors： Dattatreyamurty B,Reichert LE Jr

更新日期：1992-09-01 00:00:00

abstract：:The time- and dose-dependent effects of bovine activin A and bovine follicle stimulating hormone (FSH) suppressing protein (FSP) or follistatin on basal and FSH-induced steroidogenesis and inhibin production were studied in granulosa cells from immature, diethylstilbestrol (DES)-treated rats. In the presence of rat FS...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK,Robertson DM

更新日期：1990-02-12 00:00:00

abstract：:The transcriptional activity of various lengths of the 5'-untranslated region (UTR) of the murine LH receptor (R) gene were studied using the luciferase reporter gene in transiently transfected mouse Leydig tumor cells (mLTC-1). Chinese hamster ovarian (CHO) and HeLa cells were used as controls. The basal transcriptio...

journal_title：Molecular and cellular endocrinology

authors： El-Hefnawy T,Krawczyk Z,Nikula H,Viherä I,Huhtaniemi I

更新日期：1996-05-31 00:00:00

abstract：:It has recently been shown that mammals contain a gene encoding a protein that is related to stanniocalcin (STC), a hormone previously considered to be present only in bony fish where it plays a major role in Ca2+ homeostasis. Here we report the identification in the mouse and human of a cDNA, STC-2, that shows signif...

journal_title：Molecular and cellular endocrinology

authors： Chang AC,Reddel RR

更新日期：1998-06-25 00:00:00

abstract：:A new strain, named WRT cells, has been generated from primary cultures of rat thyroids. The primary culture was grown in Coon's modified Ham's F12 medium with 5% calf serum, insulin, hydrocortisone, transferrin, somatostatin, glycyl-L-histidyl-L-lysine and thyrotropin (TSH). On the basis of the following facts, the W...

journal_title：Molecular and cellular endocrinology

authors： Brandi ML,Rotella CM,Mavilia C,Franceschelli F,Tanini A,Toccafondi R

更新日期：1987-11-01 00:00:00

abstract：:The present study investigated the pattern and site of expression of the prolactin receptor gene in the testis of the seasonally breeding Soay sheep. In experiment 1, Northern blot analysis confirmed expression of the prolactin receptor gene in the testis which was encoded by RNA transcripts of approximately 3.6, 11.2...

journal_title：Molecular and cellular endocrinology

authors： Jabbour HN,Lincoln GA

更新日期：1999-02-25 00:00:00

abstract：:The metabolism of progesterone (PROG) by cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17α-hydroxyprogesterone (17-OHPROG) and 16α-hydroxyprogesterone (16-OHPROG) in humans. Unlike 17-OHPROG, 16-OHPROG is not metabolised further in steroidogenic tissue. While this metabolite ca...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart P,Africander D,Conradie R,Louw R,Swart AC

更新日期：2011-04-10 00:00:00

abstract：:The present study was aimed at characterizing the deficiency of the glucocorticoid-receptor system in the immature pituitary gland of neonatal rats. Under conditions of both constant protein and DNA concentrations, [3H]dexamethasone binding to nuclei was significantly lower in the immature, compared with the mature, g...

journal_title：Molecular and cellular endocrinology

authors： Sakly M,Koch B

更新日期：1982-09-01 00:00:00

abstract：:Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative association with human diseases makes them promising pharmacological targets because of the large potential to develop ligands. LXR are mainly considered as intracellular cholesterol "sensors" whose a...

journal_title：Molecular and cellular endocrinology

authors： Viennois E,Mouzat K,Dufour J,Morel L,Lobaccaro JM,Baron S

更新日期：2012-04-04 00:00:00

abstract：:Catecholamines are known to have an inhibitory effect on oviductal smooth musculature by changing the adrenergic receptors activity. In order to further investigate the role of epinephrine and/or norepinephrine in oviduct, the distribution of beta-adrenergic receptors has been studied in the rat oviduct, using in vitr...

journal_title：Molecular and cellular endocrinology

authors： Tolszczuk M,Pelletier G

更新日期：1988-11-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

journal_title：Molecular and cellular endocrinology

authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

更新日期：2013-01-05 00:00:00

abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

journal_title：Molecular and cellular endocrinology

authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

更新日期：2010-03-05 00:00:00

abstract：:Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, PC2, CPE and preproNPY protein expression levels were compared among m...

journal_title：Molecular and cellular endocrinology

authors： Tang SS,Zhang JH,Liu HX,Li HZ

更新日期：2009-05-06 00:00:00

abstract：:Spermatogonial transplantation as developed in the laboratory of Ralph Brinster has been a technological breakthrough in the study of Sertoli-germ cell interactions. For the first time, germ cells can be transferred from one animal to another and from one species to another. The transfer technology combined with devel...

journal_title：Molecular and cellular endocrinology

authors： Russell LD,Griswold MD

更新日期：2000-03-30 00:00:00

abstract：:Key reproductive events, such as menstruation and implantation, are considered to be inflammatory processes and glucocorticoids act as anti-inflammatory agents. The balance of expression of types 1 and 2 11beta-hydroxysteroid dehydrogenases (11betaHSD) controls the availability of cortisol to bind to the glucocorticoi...

journal_title：Molecular and cellular endocrinology

authors： McDonald SE,Henderson TA,Gomez-Sanchez CE,Critchley HO,Mason JI

更新日期：2006-03-27 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:Rat adipocytes in primary culture have been used to study the intracellular processing of growth hormone (GH) receptors. Pretreatment of adipocytes with 20 micrograms/ml cycloheximide resulted in a rapid decline (t1/2 approximately 45 min) of the 125I-human growth hormone (hGH) binding capacity of the cells. This decl...

journal_title：Molecular and cellular endocrinology

authors： Roupas P,Herington AC

更新日期：1988-05-01 00:00:00