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The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer cell growth.

Abstract：

:Extracts from the plant Pygeum africanum are widely used in the therapy of benign prostate hyperplasia (BPH) and in combinational therapy for prostate cancer, the second leading cause of cancer death and the mostly diagnosed form of cancer in men. The androgen receptor (AR) plays a crucial role in the development of the prostate as well as in prostate diseases. Even though the extracts from P. africanum are considered as beneficial for prostate diseases in clinical trials, and some active compounds for treatment of BPH could be identified, compounds responsible for AR inhibition and the molecular mechanism for inhibition of prostatitis need to be identified. Recently, atraric acid and N-butylbenzene-sulfonamide were isolated from a selective dichlormethane extract of P. africanum as two novel AR antagonistic compounds. The molecular mechanisms of AR inhibition were analyzed and are summarized here. Both compounds are the first known natural, complete and specific AR antagonist.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Roell D,Baniahmad A

doi

10.1016/j.mce.2010.09.013

subject

Has Abstract

pub_date

2011-01-30 00:00:00

pages

1-8

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(10)00474-0

journal_volume

332

pub_type

杂志文章,评审

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