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Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis.

Abstract：

:In previous studies, we found that endometriotic stromal cells lose the ability to regulate cell survival signaling in endometriotic epithelial cells. Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved. We found that ectopic endometriotic stromal cells (ESC) expressed and secreted higher Wnt2 protein compared with normal endometrial stromal cells (NSC). Conditioned medium (CM) from ESC supplemented with Wnt2 antibody significantly inhibited the growth of normal endometrial epithelial cells (NEC), while CM from ESC per se showed no significant effect on the growth of NEC. Metformin decreased the expression and secretion of Wnt2 in ESC. CM from Metformin-pretreated ESC significantly inhibited the growth of NEC. In conclusion, Wnt2/β-catenin signaling was involved in stromal-epithelial cells interaction in endometriosis. Metformin might regulate the stroma-epithelium communication via Wnt2-mediated signaling in endometriosis.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Zhang H,Xue J,Li M,Zhao X,Wei D,Li C

doi

10.1016/j.mce.2015.06.011

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

61-5

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(15)00321-4

journal_volume

413

pub_type

杂志文章

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