Zebrafish pancreas development.

abstract：:The effects of 3.0 mM Mn2+ on parathyroid hormone (PTH) release, 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) were studied in vitro with use of parathyroid glands from rats and cattle. Mn2+ inhibited PTH release by about 70 and 60% at Ca2+ concentrations of less than 10 nM or 0.5 mM, respectively, and li...

journal_title：Molecular and cellular endocrinology

authors： Johansson H,Larsson R,Wallfelt C,Rastad J,Akerström G,Gylfe E

更新日期：1988-09-01 00:00:00

abstract：:Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling path...

journal_title：Molecular and cellular endocrinology

authors： Schedlich LJ,Yenson VM,Baxter RC

更新日期：2013-09-05 00:00:00

abstract：:Regulation of the ovalbumin (Ov) gene is strictly controlled by precise developmental, tissue-specific, and hormonal cues. The Ov gene is transcriptionally activated by four classes of steroid hormones: estrogens, androgens, glucocorticoids, and progestins. Although it has served as a model to study multi-hormone gene...

journal_title：Molecular and cellular endocrinology

authors： Dillner NB,Sanders MM

更新日期：2002-06-28 00:00:00

abstract：:Insulin and cAMP stimulate prolactin gene transcription and prolactin-CAT expression in rat pituitary tumor GH cells. Expression of prolactin-CAT construct, pPrl(-173/+75)CAT, is stimulated 10- to 30-fold by either insulin or cAMP. Addition of both insulin and cAMP resulted in an additive 20- to 60-fold stimulation. A...

journal_title：Molecular and cellular endocrinology

authors： Jacob KK,Stanley FM

更新日期：1995-04-01 00:00:00

abstract：:Various water-insoluble cannabinoids as well as SP-111A, the water-soluble derivative of delta 9-tetrahydrocannabinol (delta 9-THC), reduced hCG and dibutyryl-cAMP stimulated testosterone production by rat testicular Leydig cell preparations. With 0.15 microM (0.05 micrograms/ml) 8-beta-OH-delta 9-THC the inhibition w...

journal_title：Molecular and cellular endocrinology

authors： Jakubovic A,McGeer EG,McGeer PL

更新日期：1979-07-01 00:00:00

abstract：:NPY receptors represent novel molecular therapeutic targets in cancer and obesity. However, the extent of NPY receptor expression in normal human tissues is poorly investigated. Based on the role of NPY in reproductive functions, the NPY receptor expression was studied in 25 normal human testes and, additionally, 24 t...

journal_title：Molecular and cellular endocrinology

authors： Körner M,Waser B,Thalmann GN,Reubii JC

更新日期：2011-04-30 00:00:00

abstract：:Epigenetic methodologies address mechanisms of estrogenic effects on hypothalamic and preoptic neurons, as well as mechanisms by which stress can interfere with female reproductive behaviors. Recent results are reviewed. ...

journal_title：Molecular and cellular endocrinology

authors： Pfaff DW,Gagnidze K,Hunter RG

更新日期：2018-05-15 00:00:00

abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

journal_title：Molecular and cellular endocrinology

authors： Ananthanarayanan VS,Kerman A

更新日期：2006-02-26 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and growth in others. We examined whether PTHrP production is greater in well-differentiated or growing beta cells and whether PTHrP induces differentiation or growth in...

journal_title：Molecular and cellular endocrinology

authors： Sawada Y,Zhang B,Okajima F,Izumi T,Takeuchi T

更新日期：2001-09-01 00:00:00

abstract：:Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) vi...

journal_title：Molecular and cellular endocrinology

authors： de Oliveira M,De Sibio MT,Mathias LS,Rodrigues BM,Sakalem ME,Nogueira CR

更新日期：2020-09-15 00:00:00

abstract：:Melanocortin 4 receptor (Mc4r/MC4R) is a G-Protein coupled receptor that is expressed in the hypothalamus and implicated in body weight control. Mutations in MC4R are the most frequent cause of monogenetic forms of human obesity. Despite its importance, the MC4R signaling pathways and transcriptional regulation underl...

journal_title：Molecular and cellular endocrinology

authors： Wankhade UD,Good DJ

更新日期：2011-07-20 00:00:00

abstract：:Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroe...

journal_title：Molecular and cellular endocrinology

authors： Vandenput L,Ohlsson C

更新日期：2014-01-25 00:00:00

abstract：:The androgen receptor (AR) is a ligand-dependent transcription activator responsible for male sexual development. In order to specifically inhibit the AR pathway, dominant negative ARs were constructed by inactivation of the major transactivation domains of the wild type AR and fusing this mutant (AR122) to the Krüppe...

journal_title：Molecular and cellular endocrinology

authors： Bramlett KS,Dits NF,Sui X,Jorge MC,Zhu X,Jenster G

更新日期：2001-10-25 00:00:00

abstract：:Type-1 diabetes (T1D) is a heterogeneous autoimmune disease, and there are pathogenetic differences between young- and adult-onset T1D patients. We hypothesized that the expressions of genes involved in costimulatory immune system pathways in peripheral blood are differently regulated in young- and adult-onset T1D. St...

journal_title：Molecular and cellular endocrinology

authors： Pruul K,Kisand K,Alnek K,Metsküla K,Reimand K,Heilman K,Peet A,Varik K,Peetsalu M,Einberg Ü,Tillmann V,Uibo R

更新日期：2015-09-05 00:00:00

abstract：:The contributions of prolactin (PRL) to breast cancer are becoming increasingly recognized. To better understand the role for PRL in this disease, its interactions with other oncogenic growth factors and hormones must be characterized. Here, we review our current understanding of PRL crosstalk with other mammary oncog...

journal_title：Molecular and cellular endocrinology

authors： Carver KC,Arendt LM,Schuler LA

更新日期：2009-08-13 00:00:00

abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

journal_title：Molecular and cellular endocrinology

authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

更新日期：1987-12-01 00:00:00

abstract：:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes,...

journal_title：Molecular and cellular endocrinology

authors： Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DA

更新日期：2013-07-05 00:00:00

abstract：:After i.m. injection of [3H]butyrobetaine into rats, the accumulation of carnitine into the epididymis, prostate gland, seminal vesicles, testis and heart was studied. The concentration of radiolabeled carnitine into the cauda epididymis increased linearly with time up to 72 h after the injection of the precursor, whi...

journal_title：Molecular and cellular endocrinology

authors： Bohmer T,Hansson V

更新日期：1975-08-01 00:00:00

abstract：:Recent work from our laboratory has focused on elucidating the mechanism of androgen regulation of the androgen receptor (AR). We have demonstrated that testosterone increases AR protein and binding within 1 h in the ventral prostate of adult rats castrated for 24 h. Cycloheximide administered with testosterone reduce...

journal_title：Molecular and cellular endocrinology

authors： Mora GR,Mahesh VB

更新日期：1996-11-29 00:00:00

abstract：:The control of progenitor cell proliferation in concert with terminal differentiation during embryonic development is poorly understood. The present paper examines this issue in the different cell lineages of the fetal mouse pituitary. Mouse fetuses were pulse-exposed to 3H-thymidine (3H-T) on a single day between emb...

journal_title：Molecular and cellular endocrinology

authors： Seuntjens E,Denef C

更新日期：1999-04-25 00:00:00

abstract：:The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmit...

journal_title：Molecular and cellular endocrinology

authors： Zemková H,Stojilkovic SS

更新日期：2018-03-05 00:00:00

abstract：:Induction of prolactin hepatic receptors in the male rat by exogenous prolactin and the possible involvement of prostaglandins in this process were studied. When ovine prolactin 500 microgram/kg was administered sc in saline containing 10% PVP (polyvinylpyrrolidone), twice daily for 6.5 days and the rats killed 48 h a...

journal_title：Molecular and cellular endocrinology

authors： Barkey RJ,Shani J,Lahav M,Amit T,Youdim MB

更新日期：1981-02-01 00:00:00

abstract：:Evidence that transforming growth factor-beta (TGF beta) is produced by porcine thecal cells and acts upon porcine granulosa cells suggests that this peptide may be a local regulator of follicular function in this species. The objective of the present study was to investigate the effects of TGF beta on steroidogenesis...

journal_title：Molecular and cellular endocrinology

authors： Engelhardt H,Tekpetey FR,Gore-Langton RE,Armstrong DT

更新日期：1992-05-01 00:00:00

abstract：:17Beta-hydroxysteroid dehydrogenase Type 1 (17beta-HSD1) has a pivotal role in regulating the synthesis of oestradiol (E2) within breast tumours. In whole body studies in postmenopausal women with breast cancer the conversion of oestrone (E1) to E2 (4.4+/-1.1%) was much lower than the inactivation of E2 to E1 (17.3+/-...

journal_title：Molecular and cellular endocrinology

authors： Purohit A,Tutill HJ,Day JM,Chander SK,Lawrence HR,Allan GM,Fischer DS,Vicker N,Newman SP,Potter BV,Reed MJ

更新日期：2006-03-27 00:00:00

abstract：:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in...

journal_title：Molecular and cellular endocrinology

authors： Wang CY,Chen WY,Lai PY,Chung BC

更新日期：2013-05-22 00:00:00

abstract：:Severe inflammation in the islets is observed in obese patients with type 2 diabetes. Inflammation in the islets is caused by obesity-induced serum free fatty acids. Asprosin is a fasting-induced adipokine, which contributes to hepatic glucose production. However, the effects of asprosin on inflammation and cellular d...

journal_title：Molecular and cellular endocrinology

authors： Lee T,Yun S,Jeong JH,Jung TW

更新日期：2019-04-15 00:00:00

abstract：:The role of AII receptors subtypes, AT1 and AT2, in the regulation of aldosterone secretion was studied in adrenal glomerulosa cells and membranes from rats on normal and low sodium intake, using AII receptor subtype-specific antagonists. In adrenal glomerulosa cells, more than 90% of the receptors were AT1 and there ...

journal_title：Molecular and cellular endocrinology

authors： Aguilera G

更新日期：1992-12-01 00:00:00

abstract：:Delphinidin possesses the highest chemopreventive activity among the six components of anthocyanidin that are pigments from fruits and vegetables giving them blue, purple or red colors. Although delphinidin has anti-carcinogenic and apoptotic effects in various cancers, little is known about its functional roles in ov...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Jeong W,Song G

更新日期：2016-02-15 00:00:00

abstract：:To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

journal_title：Molecular and cellular endocrinology

authors： Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

更新日期：2013-01-30 00:00:00

abstract：:Neuropeptide Y (NPY) is expressed in adipose tissue and is involved in adipocyte metabolism. Although NPY impacts on glucose utilization in vivo, the underlying cellular mechanism is yet to be fully elucidated. In this study we investigated the effect of NPY on the insulin-stimulated translocation of glucose transport...

journal_title：Molecular and cellular endocrinology

authors： Gericke MT,Schröder T,Kosacka J,Nowicki M,Klöting N,Spanel-Borowski K

更新日期：2012-01-02 00:00:00