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Calcium-agonistic action of Mn2+ in the parathyroid cell.

Abstract：

:The effects of 3.0 mM Mn2+ on parathyroid hormone (PTH) release, 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) were studied in vitro with use of parathyroid glands from rats and cattle. Mn2+ inhibited PTH release by about 70 and 60% at Ca2+ concentrations of less than 10 nM or 0.5 mM, respectively, and like the inhibitory effect of Ca2+, that of Mn2+ was rapid and reversible. Mn2+-induced inhibition of the PTH release was associated with reduction of 45Ca uptake by about 50% and a marked but temporary increase in 45Ca efflux. Mn2+ induced a rapid transient increase in Ca2+i provided that the intracellular release of Ca2+ had not already been triggered by previous exposure to 3.0 mM Ca2+. This initial action was apparently followed by influx of Mn2+, since pronounced quenching of the fluorescence from the Ca2+ indicator fura-2 was observed. The results indicate that Mn2+ behaves in several respects like a calcium analogue in parathyroid cells and may inhibit PTH release by interfering directly with the secretory machinery.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Johansson H,Larsson R,Wallfelt C,Rastad J,Akerström G,Gylfe E

doi

10.1016/0303-7207(88)90197-9

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

77-82

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

0303-7207(88)90197-9

journal_volume

59

pub_type

杂志文章

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