Involvement of Bcl-2 family proteins in germ cell apoptosis during testicular development in the rat and pro-survival effect of stem cell factor on germ cells in vitro.

abstract：:Transforming growth factor beta (TGF beta) caused a dose-dependent increase in both basal and follicle-stimulating hormone (FSH)-stimulated inhibin production by rat granulosa cells in culture. The TGF beta dose-response curve in the absence of FSH was approximately parallel to that in the presence of either a minimal...

journal_title：Molecular and cellular endocrinology

authors： Zhang ZW,Findlay JK,Carson RS,Herington AC,Burger HG

更新日期：1988-08-01 00:00:00

abstract：:Proinsulin folding imperfections cause extensive beta-cell defects known in diabetes. Here, we investigated whether exenatide can alleviate such defects in proinsulin conversion, beta-cell survival, and insulin secretion, in the Ins2+/Akita beta-cells that have a spontaneous mutation (Cys 96 Tyr) in the insulin 2 gene...

journal_title：Molecular and cellular endocrinology

authors： Tang W,Yuan Q,Xu B,Osei K,Wang J

更新日期：2017-01-05 00:00:00

abstract：:In recent years it has become evident that glucocorticoid receptor (GR) action in the nucleus is highly dynamic, characterized by a rapid exchange at the chromatin template. This stochastic mode of GR action couples perfectly with a deterministic pulsatile availability of endogenous ligand in vivo. The endogenous gluc...

journal_title：Molecular and cellular endocrinology

authors： Conway-Campbell BL,Pooley JR,Hager GL,Lightman SL

更新日期：2012-01-30 00:00:00

abstract：:During development, the insulin-like growth factor I (IGF-I) gene is expressed in a tissue specific manner; however, the molecular mechanisms governing its developmental regulation remain poorly defined. To examine the hypothesis that expression of the growth hormone (GH) receptor accounts, in part, for the tissue spe...

journal_title：Molecular and cellular endocrinology

authors： Shoba L,An MR,Frank SJ,Lowe WL Jr

更新日期：1999-06-25 00:00:00

abstract：:Skeletal muscle atrophy is a debilitating response to several major diseases, muscle disuse and chronic steroid treatment for which currently no therapy is available. Since adiponectin signaling plays key roles in muscle energetics, we assessed if globular adiponectin (gAd) or the small molecule adiponectin mimetic 6-...

journal_title：Molecular and cellular endocrinology

authors： Singh AK,Shree S,Chattopadhyay S,Kumar S,Gurjar A,Kushwaha S,Kumar H,Trivedi AK,Chattopadhyay N,Maurya R,Ramachandran R,Sanyal S

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS...

journal_title：Molecular and cellular endocrinology

authors： Bernardi S,Fabris B,Thomas M,Toffoli B,Tikellis C,Candido R,Catena C,Mulatero P,Barbone F,Radillo O,Zauli G,Secchiero P

更新日期：2014-08-25 00:00:00

abstract：:Insulin stimulates rapid tyrosine phosphorylation of the protein Shc, which subsequently binds to Grb2, resulting in the activation of a complex mitogenic signaling network. In this study, we examined the levels of Shc protein, its phosphorylation state and Shc-Grb2 association in liver, muscle and adipose tissue befo...

journal_title：Molecular and cellular endocrinology

authors： Páez-Espinosa EV,Rocha EM,Velloso LA,Boschero AC,Saad MJ

更新日期：1999-10-25 00:00:00

abstract：:Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesi...

journal_title：Molecular and cellular endocrinology

authors： Louw-du Toit R,Storbeck KH,Cartwright M,Cabral A,Africander D

更新日期：2017-02-05 00:00:00

abstract：:The defining characteristic of obesity is increased adipose tissue (AT) mass following chronic positive energy supply. AT mass is determined by adipocyte number and size, which reflect proliferation and differentiation of preadipocytes and hypertrophy of pre-existing adipocytes. The molecular pathways governing AT exp...

journal_title：Molecular and cellular endocrinology

authors： Hutley LJ,Newell FS,Kim YH,Luo X,Widberg CH,Shurety W,Prins JB,Whitehead JP

更新日期：2011-06-06 00:00:00

abstract：:Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism (CH), a relatively frequent endocrine disease in newborns (1 in 3000-4000 live births). TD is a defect in the organogenesis of the gland resulting in hypoplastic, ectopic or absent-thyroid gland. TD is usually sporadic but mutations in trans...

journal_title：Molecular and cellular endocrinology

authors： Montanelli L,Tonacchera M

更新日期：2010-06-30 00:00:00

abstract：:Northern blot analysis of total RNA from a variety of rabbit tissues indicated that placenta is the primary site of expression of the protein hormone relaxin (previously called SQ10) in rabbits. Relaxin was not detected by this method in other rabbit tissues, including normal trachea and several squamous tissues. Howe...

journal_title：Molecular and cellular endocrinology

authors： Bernacki SH,Medvedev A,Holloway G,Dawson M,Lotan R,Jetten AM

更新日期：1998-03-16 00:00:00

abstract：:Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated by alpha and beta isoforms of TH receptor which act as ligand-regulate...

journal_title：Molecular and cellular endocrinology

authors： Nunez J,Celi FS,Ng L,Forrest D

更新日期：2008-06-11 00:00:00

abstract：:The implantation of the Lewis lung carcinoma (a fast-growing mouse tumour that induces cachexia) to both wild-type and gene-deficient mice for the tumour necrosis factor (TNF) receptor type I protein (Tnfr1(0)/Tnfr1(0)), resulted in a considerable loss of carcass (26%) and white (77%) and brown adipose (37%) tissue we...

journal_title：Molecular and cellular endocrinology

authors： López-Soriano J,Llovera M,Carbó N,García-Martínez C,López-Soriano FJ,Argiles JM

更新日期：1997-09-19 00:00:00

abstract：:The effect of a polyclonal anti-insulin receptor antibody (pIgG) on the insulin receptor tyrosine kinase (IRTK) activity toward poly-(Glu-Tyr) was examined using wheat germ agglutinin agarose-purified insulin receptors from rat liver membranes. The main effect of pIgG was a reduction of Vmax (from 60.8 to 31.8 pmol/mi...

journal_title：Molecular and cellular endocrinology

authors： Gherzi R,Cordera R,Andraghetti G,De Pirro R,Freidenberg GR,Lauro R,Adezati L

更新日期：1987-09-01 00:00:00

abstract：:The availability of regulatory sequences directing tissue-specific expression of transgenes in genetically modified mice and large animals is a prerequisite for the development of adequate models for human diseases. The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic beta-...

journal_title：Molecular and cellular endocrinology

authors： Grzech M,Dahlhoff M,Herbach N,Habermann FA,Renner-Müller I,Wanke R,Flaswinkel H,Wolf E,Schneider MR

更新日期：2010-02-05 00:00:00

abstract：:The present study investigated the pattern and site of expression of the prolactin receptor gene in the testis of the seasonally breeding Soay sheep. In experiment 1, Northern blot analysis confirmed expression of the prolactin receptor gene in the testis which was encoded by RNA transcripts of approximately 3.6, 11.2...

journal_title：Molecular and cellular endocrinology

authors： Jabbour HN,Lincoln GA

更新日期：1999-02-25 00:00:00

abstract：:FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mil...

journal_title：Molecular and cellular endocrinology

authors： Caburet S,Georges A,L'Hôte D,Todeschini AL,Benayoun BA,Veitia RA

更新日期：2012-06-05 00:00:00

abstract：:The major ganglioside NeuAc alpha 2-->3Gal beta 1-->4Glc beta 1-->1Cer (GM3) present in cultured rat granulosa cells was examined for potential function in the expression of luteinizing hormone (LH) receptor on the cell surface in response to follicle-stimulating hormone (FSH). Synthesis of GM3 was stimulated concentr...

journal_title：Molecular and cellular endocrinology

authors： Hattori M,Horiuchi R

更新日期：1992-10-01 00:00:00

abstract：:The most potent, physiologic activator of proopiomelanocortin (POMC) gene transcription is corticotropin releasing hormone (CRH) and increased intracellular cAMP is critical for this effect. The 5'-flanking region of the murine POMC gene has several potential binding sites for regulatory proteins. To characterize the ...

journal_title：Molecular and cellular endocrinology

authors： Bishop JF,Mouradian MM

更新日期：1993-11-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase type 1 (17-HSD type 1) is a steroidogenic enzyme catalyzing reversible interconversion of estradiol and estrone. 17-HSD type 1 is actively expressed in human placenta. We characterized 17-HSD type 1 expression and its regulation by basic fibroblast growth factor (bFGF) in JAR, JEG-...

journal_title：Molecular and cellular endocrinology

authors： Lewintre EJ,Orava M,Peltoketo H,Vihko R

更新日期：1994-08-01 00:00:00

abstract：:Imprinted gene expression in preimplantation development has been extensively studied in the mouse. Different imprinted genes vary in their time of onset of expression and also in the timing and tissue-specificity of mono-allelic expression. We have surveyed a range of imprinted genes for expression, and mono-allelic ...

journal_title：Molecular and cellular endocrinology

authors： Monk M,Salpekar A

更新日期：2001-10-22 00:00:00

abstract：:As deduced on the basis of cloning experiments, the putative extracellular domain of pituitary glycoprotein hormone (lutropin (LH), thyrotropin (TSH), and FSH) receptors (rec) is sufficiently large to suggest involvement in hormone binding. Comparison of the amino acid sequences of the extracellular domains of the gly...

journal_title：Molecular and cellular endocrinology

authors： Dattatreyamurty B,Reichert LE Jr

更新日期：1992-09-01 00:00:00

abstract：:Mammalian gonadotropins are highly selective. Charge differences between the Cys(10-11) sequence of FSHbeta and LHbeta/CGbeta seat-belt loops determine the ability of these hormones to interact with the LH-R. Selective FSH-R binding is mainly dependent on the presence of an FSHbeta-specific sequence between Cys(11-12)...

journal_title：Molecular and cellular endocrinology

authors： Vischer HF,Marques RB,Granneman JC,Linskens MH,Schulz RW,Bogerd J

更新日期：2004-09-30 00:00:00

abstract：:The main objective of this study was to characterize nuclear T3 and T4 binding in the developing rat brain. More specifically, we sought to determine (a) whether T3 and T4 bind to the same nuclear receptor, (b) whether there are multiple forms of nuclear T3 or T4 receptors, and (c) whether the above parameters are sim...

journal_title：Molecular and cellular endocrinology

authors： Margarity M,Matsokis N,Valcana T

更新日期：1983-08-01 00:00:00

abstract：:Maternal effects on early postnatal development in mammals are mediated, in part, by milk-borne bioactive factors transmitted from mother to nursing offspring. The term 'lactocrine' was coined to describe this mode of signaling. Relaxin (RLX), one of a family of neohormones found in mammals, is detectable in milk from...

journal_title：Molecular and cellular endocrinology

authors： Bagnell CA,Bartol FF

更新日期：2019-05-01 00:00:00

abstract：:The influence of drug-receptor binding kinetics has often been overlooked during the development of new therapeutics that target G protein-coupled receptors (GPCRs). Over the last decade there has been a growing understanding that an in-depth knowledge of binding kinetics at GPCRs is required to successfully target th...

journal_title：Molecular and cellular endocrinology

authors： Sykes DA,Stoddart LA,Kilpatrick LE,Hill SJ

更新日期：2019-04-05 00:00:00

abstract：:Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP...

journal_title：Molecular and cellular endocrinology

authors： Flajollet S,Lefebvre B,Cudejko C,Staels B,Lefebvre P

更新日期：2007-05-30 00:00:00

abstract：:Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to...

journal_title：Molecular and cellular endocrinology

authors： Purohit A,Woo LW,Potter BV

更新日期：2011-07-04 00:00:00

abstract：:Factors that regulate the tissue specific and developmental expression of the GLUT4 gene, whose transcribed protein is primarily responsible for mediating insulin stimulated glucose transport, are poorly defined. In this study we examined the effects of retinoic acid, a circulating factor that can promote cellular dif...

journal_title：Molecular and cellular endocrinology

authors： Sleeman MW,Zhou H,Rogers S,Ng KW,Best JD

更新日期：1995-02-27 00:00:00

abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

journal_title：Molecular and cellular endocrinology

authors： Podesta EJ,Dufau ML,Catt KJ

更新日期：1976-06-01 00:00:00