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Relaxin and the 'Milky Way': The lactocrine hypothesis and maternal programming of development.

Abstract：

:Maternal effects on early postnatal development in mammals are mediated, in part, by milk-borne bioactive factors transmitted from mother to nursing offspring. The term 'lactocrine' was coined to describe this mode of signaling. Relaxin (RLX), one of a family of neohormones found in mammals, is detectable in milk from multiple species. In the pig, evidence of bioactive proRLX in colostrum/milk, immunoreactive RLX in the circulation of nursed neonates, and RLX receptor expression in RLX-sensitive neonatal female reproductive tract tissues, established RLX as a prototypical lactocrine-active factor. Observations provided the foundation for the lactocrine hypothesis for maternal programming of postnatal development. Studies designed to test the lactocrine hypothesis provided insights into both short-term effects of milk-borne bioactive factors in the neonate, and long-term consequences of maternal lactocrine programming of endometrial function and fecundity in adults. Thus, RLX led to the 'Milky Way'.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Bagnell CA,Bartol FF

doi

10.1016/j.mce.2019.01.003

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

18-23

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(19)30003-6

journal_volume

487

pub_type

杂志文章,评审

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