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Hyperthyroidism in the developing rat testis is associated with oxidative stress and hyperphosphorylated vimentin accumulation.

Abstract：

:Hyperthyroidism was induced in rats and somatic indices and metabolic parameters were analyzed in testis. In addition, the morphological analysis evidenced testes maturation and intense protein synthesis and processing, supporting the enhancement in vimentin synthesis in hyperthyroid testis. Furthermore, vimentin phosphorylation was increased, indicating an accumulation of phosphorylated vimentin associated to the cytoskeleton, which could be a consequence of the extracellular-regulated kinase (ERK) activation regulating the cytoskeleton. Biomarkers of oxidative stress demonstrated an increased basal metabolic rate measured by tissue oxygen consumption, as well as, increased TBARS levels. In addition, the enzymatic and non-enzymatic antioxidant defences appeared to respond according to the augmented oxygen consumption. We observed decreased total glutathione levels, with enhancement of reduced glutathione, whereas most of the antioxidant enzyme activities were induced. Otherwise, superoxide dismutase activity was inhibited. These results support the idea that an increase in mitochondrial ROS generation, underlying cellular oxidative damage, is a side effect of hyperthyroid-induced biochemical changes by which rat testis increase their metabolic capacity.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Zamoner A,Barreto KP,Filho DW,Sell F,Woehl VM,Guma FC,Silva FR,Pessoa-Pureur R

doi

10.1016/j.mce.2007.01.005

subject

Has Abstract

pub_date

2007-03-15 00:00:00

pages

116-26

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(07)00026-3

journal_volume

267

pub_type

杂志文章

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