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Adrenocortical cell lines.

Abstract：

:The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids, glucocorticoids and adrenal androgens. These steroids arise from morphologically and biochemically distinct zones of the adrenal gland. Studying secretion of these distinct steroid hormones can make use of cells isolated from the adrenal gland but this requires animal sacrifice and the need for continued isolation for long-term studies. In addition primary cultures of adrenal cells have a limited life-span in culture and the cultured cells are often contaminated by the presence of non-steroidogenic cells. For that reason in vitro cell culture models have several benefits for research on adrenocortical function. Herein we discuss the available adrenocortical cell lines and their uses as model systems for adrenal studies. Focus is placed on the human NCI-H295 and mouse Y-1 adrenal cell lines, which have been used extensively as adrenocortical model systems. These cell lines have proven to be of considerable value in studying the molecular and biochemical mechanisms controlling adrenal steroidogenesis. The current review will discuss the attributes and limitations of the currently available adrenocortical cell lines as models for adrenal studies.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Rainey WE,Saner K,Schimmer BP

doi

10.1016/j.mce.2003.12.020

keywords:

subject

Has Abstract

pub_date

2004-12-30 00:00:00

pages

23-38

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(04)00260-6

journal_volume

228

pub_type

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