Sex- and age-associated differences in episodic-like memory and transcriptional regulation of hippocampal steroidogenic enzymes in rats.

abstract：:Stanniocalcin (STC) (formerly known as both teleocalcin and hypocalcin) is an anti-hypercalcemic, glycoprotein hormone that is produced by the corpuscles of Stannius (CS), endocrine glands that are confined to bony fishes. The hormone has a unique amino acid sequence and exists as a disulfide-linked homodimer in the n...

journal_title：Molecular and cellular endocrinology

authors： Wagner GF,Dimattia GE,Davie JR,Copp DH,Friesen HG

更新日期：1992-12-01 00:00:00

abstract：:The Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder characterised both by reproductive and metabolic disturbance, and is the most common cause globally of ovarian infertility. It is also a familial polygenic condition, linked genetically to both Type 2 diabetes and the metabolic syndrome. The striking...

journal_title：Molecular and cellular endocrinology

authors： Corbett S,Morin-Papunen L

更新日期：2013-07-05 00:00:00

abstract：:Thyroid dysgenesis is the most frequent cause of congenital hypothyroidism, but its molecular pathophysiology is largely unknown. Our hypothesis that some genes downstream to thyroid transcription factor-2 (TTF-2) might be responsible for development of the thyroid prompted us to identify genes whose expression is sti...

journal_title：Molecular and cellular endocrinology

authors： Hishinuma A,Ohmika N,Namatame T,Ieiri T

更新日期：2004-06-30 00:00:00

abstract：:We previously demonstrated the interactions of different chemical compounds with estrogen receptors ERalpha and ERbeta and the androgen receptor (AR) using different reporter cell lines. In this study, we characterize the ERalpha, ERbeta and AR activity of different biphenyls using the same tools. We provide evidence ...

journal_title：Molecular and cellular endocrinology

authors： Paris F,Balaguer P,Térouanne B,Servant N,Lacoste C,Cravedi JP,Nicolas JC,Sultan C

更新日期：2002-07-31 00:00:00

abstract：:Using primary cultures of porcine Sertoli cells as a model, the effects of ovine prolactin (oPRL) on Sertoli cell function were investigated through FSH binding. PRL treatment (0.3-5 ng/ml) induced a dose-dependent increase (ED50 = 5.10(-11) M) of 125I-FSH binding to Sertoli cells to a maximal stimulation (about 2.5-f...

journal_title：Molecular and cellular endocrinology

authors： Guillaumot P,Tabone E,Benahmed M

更新日期：1996-09-18 00:00:00

abstract：:Mammalian gonadotropins are highly selective. Charge differences between the Cys(10-11) sequence of FSHbeta and LHbeta/CGbeta seat-belt loops determine the ability of these hormones to interact with the LH-R. Selective FSH-R binding is mainly dependent on the presence of an FSHbeta-specific sequence between Cys(11-12)...

journal_title：Molecular and cellular endocrinology

authors： Vischer HF,Marques RB,Granneman JC,Linskens MH,Schulz RW,Bogerd J

更新日期：2004-09-30 00:00:00

abstract：:The introduction of exogenous DNA into mammalian cells is commonly used to study the functions of gene products. However cells in primary culture are usually refractory to most transfection systems. Here we investigated the ability of a new lipid formulation, FuGENE 6 transfection reagent, to promote DNA uptake into d...

journal_title：Molecular and cellular endocrinology

authors： Uyttersprot N,Costagliola S,Miot F

更新日期：1998-07-25 00:00:00

abstract：:Relaxin is a peptide hormone which consists of two polypeptide chains that are synthesized as a B-chain/C-peptide/A-chain precursor. We have used the polymerase chain reaction (PCR) to isolate and clone a relaxin-like cDNA from sheep placental RNA. This cDNA and two sheep genomic clones were characterised by nucleotid...

journal_title：Molecular and cellular endocrinology

authors： Roche PJ,Crawford RJ,Tregear GW

更新日期：1993-02-01 00:00:00

abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

journal_title：Molecular and cellular endocrinology

authors： Podesta EJ,Dufau ML,Catt KJ

更新日期：1976-06-01 00:00:00

abstract：:Inflammation causes male hypogonadism. Several inflammatory cytokines, including interleukin 6 (IL-6), are released into the blood and may suppress Leydig cell development. The objective of the present study was to investigate whether IL-6 affected the proliferation and differentiation of rat stem Leydig cells. Leydig...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Chen L,Xie L,Li L,Li X,Li H,Liu J,Chen X,Mao B,Song T,Lian Q,Ge RS

更新日期：2018-09-05 00:00:00

abstract：:The major ganglioside NeuAc alpha 2-->3Gal beta 1-->4Glc beta 1-->1Cer (GM3) present in cultured rat granulosa cells was examined for potential function in the expression of luteinizing hormone (LH) receptor on the cell surface in response to follicle-stimulating hormone (FSH). Synthesis of GM3 was stimulated concentr...

journal_title：Molecular and cellular endocrinology

authors： Hattori M,Horiuchi R

更新日期：1992-10-01 00:00:00

abstract：:In human granulosa-lutein cells, high-density lipoproteins (HDL) can stimulate progesterone synthesis. The objective of the present study was to establish whether prostaglandins (PGs) participate in the steroidogenic response to HDL. Both HDL and apolipoprotein AI (ApoAI) stimulated concentration-dependent increases i...

journal_title：Molecular and cellular endocrinology

authors： Chandras C,Ragoobir J,Barrett GE,Bruckdorfer KR,Graham A,Abayasekara DR,Michael AE

更新日期：2004-07-30 00:00:00

abstract：:Induction of prolactin hepatic receptors in the male rat by exogenous prolactin and the possible involvement of prostaglandins in this process were studied. When ovine prolactin 500 microgram/kg was administered sc in saline containing 10% PVP (polyvinylpyrrolidone), twice daily for 6.5 days and the rats killed 48 h a...

journal_title：Molecular and cellular endocrinology

authors： Barkey RJ,Shani J,Lahav M,Amit T,Youdim MB

更新日期：1981-02-01 00:00:00

abstract：:Developmental signalling pathways are implicated in the formation and maintenance of the adrenal gland, but their roles are currently not well defined. In recent years it has emerged that Sonic hedgehog (Shh) and Wnt/β catenin signalling are crucial for the growth and development of the adrenal cortex. Here we demonst...

journal_title：Molecular and cellular endocrinology

authors： Guasti L,Candy Sze WC,McKay T,Grose R,King PJ

更新日期：2013-05-22 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

journal_title：Molecular and cellular endocrinology

authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

更新日期：2013-01-05 00:00:00

abstract：:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF...

journal_title：Molecular and cellular endocrinology

authors： Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

更新日期：2015-01-05 00:00:00

abstract：:The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids, glucocorticoids and adrenal androgens. These steroids arise from morphologically and biochemically distinct zones of the adrenal gland. Studying secretion of these distinct steroid hormones can make use of cells isolated from the a...

journal_title：Molecular and cellular endocrinology

authors： Rainey WE,Saner K,Schimmer BP

更新日期：2004-12-30 00:00:00

abstract：:A rapid and sensitive assay of iodothyronine-5'-monodeiodinase (5'-D) was developed using Sephadex column chromatography for separation of substrate 125I-rT3 from the product free 125I-. The distribution of 5'-D activity on rat kidney cortex cell membranes was examined in isopycnic zonal centrifugation experiments usi...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P,Jørgensen PL

更新日期：1988-03-01 00:00:00

abstract：:Characteristics of the alpha-adrenergic stimulation of ACTH, beta-endorphin + beta-LPH and alpha-MSH release were studied in rat anterior pituitary cells in primary culture. Parallel changes of ACTH, beta-endorphin + beta-LPH and alpha-MSh release were found under all stimulatory and inhibitory conditions by natural a...

journal_title：Molecular and cellular endocrinology

authors： Raymond V,Lépine J,Giguère V,Lissitzky JC,Côté J,Labrie F

更新日期：1981-06-01 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells. Plasma SHBG is secreted by the liver under the control of hormones and nutritional factors. In the human hepatoma cell line (HepG2), thyroid and estrogenic hor...

journal_title：Molecular and cellular endocrinology

authors： Pugeat M,Nader N,Hogeveen K,Raverot G,Déchaud H,Grenot C

更新日期：2010-03-05 00:00:00

abstract：:A comparative study of hGH and IL2 post-signaling effects, as examined by RNA expression (Nb29) and protein levels of the heat-shock protein hsp70, was performed in a hormone-dependent rat lymphoma cell line, Nb2-11C. Optimal doses of hGH or IL2 increased Nb29 expression in a dose-dependent manner. Addition of both mi...

journal_title：Molecular and cellular endocrinology

authors： Horn S,Cohen R,Gertler A

更新日期：1994-11-01 00:00:00

abstract：:The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the proces...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Zhu P,Wang W,Li W,Shu Q,Chen ZJ,Myatt L,Sun K

更新日期：2016-03-15 00:00:00

abstract：:Porcine Leydig cells in primary culture were incubated to equilibrium with increasing doses of either porcine luteinizing hormone (pLH) or human chorionic gonadotropin (hCG). Then, free and total high affinity gonadotropin receptors on the cell surface were dosed with [125I]hCG as tracer. In isotonic high salt medium,...

journal_title：Molecular and cellular endocrinology

authors： Genty N,Salesse R,Jallal B,Garnier J

更新日期：1991-04-01 00:00:00

abstract：:Meiosis-activating sterol (MAS) has been shown to induce mouse oocytes cultured in the presence of hypoxanthine (HX) to resume meiosis. The present research was conducted to determine whether amphotericin B or ketoconazole (a promoter and an inhibitor of production of MAS), affected oocyte maturation. Mouse cumulus ce...

journal_title：Molecular and cellular endocrinology

authors： Lu Z,Xia G,Byskov AG,Andersen CY

更新日期：2000-06-01 00:00:00

abstract：:Estrogen receptor β (ERβ) and its isoforms have different putative functions and expression patterns in prostate cancer. Current studies on 5'-most exons, 0K and 0N, show that their respective promoters are actively involved in transcription. These data, however, do not explain why ERβ isoforms are differentially expr...

journal_title：Molecular and cellular endocrinology

authors： Lee MT,Ouyang B,Ho SM,Leung YK

更新日期：2013-08-25 00:00:00

abstract：:Metastatic renal cell carcinomas (RCC) remain highly resistant to systemic therapy. RCCs are highly vascular tumors, which overproduce angiogenic peptides such as vascular endothelial growth factor (VEGF) even under normoxic conditions. A potential suggested role of antiangiogenic therapeutic strategies is the treatme...

journal_title：Molecular and cellular endocrinology

authors： Iwai A,Fujii Y,Kawakami S,Takazawa R,Kageyama Y,Yoshida MA,Kihara K

更新日期：2004-10-29 00:00:00

abstract：:The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-receptor (FSHR), LH-receptor (LHR), AMH-receptor2 (AMHR2), CYP19a, and androgen-rece...

journal_title：Molecular and cellular endocrinology

authors： Jeppesen JV,Nielsen ME,Kristensen SG,Yding Andersen C

更新日期：2012-06-05 00:00:00

abstract：:The chum salmon insulin-like growth factor II (IGF-II) gene is highly expressed in liver tissue. In this study we demonstrate that two transcription factors, Sp1 and C/EBPbeta, are involved in the enhanced expression of the salmon IGF-II gene. The presence of the fish homolog for C/EBPbeta in salmon liver RNA was conf...

journal_title：Molecular and cellular endocrinology

authors： Palamarchuk AY,Kavsan VM,Sussenbach JS,Holthuizen PE

更新日期：2001-02-14 00:00:00

abstract：:The defining characteristic of obesity is increased adipose tissue (AT) mass following chronic positive energy supply. AT mass is determined by adipocyte number and size, which reflect proliferation and differentiation of preadipocytes and hypertrophy of pre-existing adipocytes. The molecular pathways governing AT exp...

journal_title：Molecular and cellular endocrinology

authors： Hutley LJ,Newell FS,Kim YH,Luo X,Widberg CH,Shurety W,Prins JB,Whitehead JP

更新日期：2011-06-06 00:00:00

abstract：:Adrenocortical tumor (ACT), a rare tumor with a heterogeneous presentation, incompletely understood pathogenesis, and generally poor prognosis, occurs in 1-2 people per million and is even more uncommon in the pediatric population. Such rare cancers are a challenge to clinical practice. Exchange of experience, informa...

journal_title：Molecular and cellular endocrinology

authors： Ribeiro RC,Pinto EM,Zambetti GP,Rodriguez-Galindo C

更新日期：2012-03-31 00:00:00