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Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins.

Abstract：

:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts, both at protein and mRNA levels. Competition studies showed that each of the domain-types interacts with its own receptor. Induction of IGF-1 expression caused by domains of different types showed dissimilar sensitivity to inhibitors of regulatory cascades. The effect of Fn type III domains was more sensitive to inhibition of Ca(2+)/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of the adenylyl cyclase-cAMP-PKA pathway.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

doi

10.1016/j.mce.2014.08.010

subject

Has Abstract

pub_date

2015-01-05 00:00:00

pages

69-77

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00247-0

journal_volume

399

pub_type

杂志文章

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