Identification of a minor Tg mRNA transcript in RNA from normal and goitrous thyroids.

abstract：:In mammalian cells, the insulin receptor substrate 1 protein (IRS-1) is a specific substrate for insulin and IGF-1 receptor tyrosine kinases which is involved in mediating metabolic and mitogenic actions of insulin and IGFs. In order to determine if IRS-1 is also essential in a chicken derived hepatoma cell line (LMH ...

journal_title：Molecular and cellular endocrinology

authors： Taouis M,Dupont J,Gillet A,Derouet M,Simon J

更新日期：1998-02-01 00:00:00

abstract：:A small litter (SL) model was used to determine how neonatal overfeeding affects the homeostatic control of food intake in male rats at weaning and postnatal day (PND) 90. At PND4, litters were reduced to small (4 pups/dam) or normal (10 pups/dam) litters. At weaning, SL rats showed higher body weight and characterist...

journal_title：Molecular and cellular endocrinology

authors： Schumacher R,Rossetti MF,Lazzarino GP,Canesini G,García AP,Stoker C,Andreoli MF,Ramos JG

更新日期：2021-02-15 00:00:00

abstract：:Interaction of tamoxifen, trioxifene and LY117018 with cytosol-estrogen receptors from immature rat uteri was compared. Determination of relative binding affinity (RBA) by competition with [3H] estradiol under various assay conditions revealed that the RBA of LY117018 increased with temperature while that of trioxifen...

journal_title：Molecular and cellular endocrinology

authors： Black LJ,Jones CD,Goode RL

更新日期：1981-04-01 00:00:00

abstract：:Corticotropin (ACTH) binds to specific receptors in the adrenal cortex and thereby regulates glucocorticoid and mineralocorticoid production. The number of ACTH binding sites on adrenocortical cells is increased by exposure of cells to activators of the cAMP pathway. The mechanism responsible for the increase in ACTH ...

journal_title：Molecular and cellular endocrinology

authors： Mountjoy KG,Bird IM,Rainey WE,Cone RD

更新日期：1994-02-01 00:00:00

abstract：:The classic renin-angiotensin system (RAS) is a complex system in which angiotensin II (Ang II) has been identified as an important endogenous regulator that influences both smooth muscle contraction and cell growth. Although a local RAS is known to exist in the gastrointestinal tract, it is unclear whether Ang II is ...

journal_title：Molecular and cellular endocrinology

authors： Zhang CM,Huang X,Lu HL,Meng XM,Liu DH,Kim YC,Xu WX

更新日期：2016-03-05 00:00:00

abstract：:Conventional in vitro autoradiographical techniques have been used to screen a number of ovine peripheral tissues for the presence of specific 2-[125I]iodomelatonin binding sites. Intense specific labelling (defined as that displaced by 1 microM melatonin) was observed in the adrenal cortex, and less intense specific ...

journal_title：Molecular and cellular endocrinology

authors： Helliwell RJ,Howell HE,Lawson W,Barrett P,Morgan PJ

更新日期：1994-08-01 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is the common precursor of several pituitary hormones including alpha-melanotropic hormone, adrenocorticotropic hormone, beta-lipotropin and beta-endorphin. The porcine POMC cDNA was inserted downstream from the late promoter of an SV40-derived expression vector and co-transfected in NIH 3T...

journal_title：Molecular and cellular endocrinology

authors： Zollinger L,Noël G,Des Parois L,Sales V,Crine P,Boileau G

更新日期：1988-07-01 00:00:00

abstract：:It has recently been shown that mammals contain a gene encoding a protein that is related to stanniocalcin (STC), a hormone previously considered to be present only in bony fish where it plays a major role in Ca2+ homeostasis. Here we report the identification in the mouse and human of a cDNA, STC-2, that shows signif...

journal_title：Molecular and cellular endocrinology

authors： Chang AC,Reddel RR

更新日期：1998-06-25 00:00:00

abstract：:Melatonin can be synthesized and secreted not only by the pineal gland but also by many extra-pineal tissues. It has been shown that many ovarian functions are regulated by melatonin locally. Ovarian hyperstimulation syndrome (OHSS) is a serious complication during ovulation induction of the in vitro fertilization tre...

journal_title：Molecular and cellular endocrinology

authors： Li Y,Fang L,Zhang R,Wang S,Li Y,Yan Y,Yu Y,Cheng JC,Sun YP

更新日期：2020-12-01 00:00:00

abstract：:The binding of thyrotropin (TSH) to the TSH receptor (TSHR) activates two signaling pathways: the cAMP-protein kinase A (PKA) and the protein kinase C (PKC) systems. We have recently demonstrated that TSH activates the Janus kinases (JAK)/signal transducer and activator of transcription (STAT) pathway via TSHR. This s...

journal_title：Molecular and cellular endocrinology

authors： Park YJ,Park ES,Kim MS,Kim TY,Lee HS,Lee S,Jang IS,Shong M,Park DJ,Cho BY

更新日期：2002-08-30 00:00:00

abstract：:The expression of the gene coding for thyroperoxydase, the main enzyme involved in the synthesis of the thyroid hormones, is controlled by thyroid stimulating hormone. In vitro transcription assays performed on nuclei isolated from dog thyroid cells in primary culture showed that this control is at the transcription l...

journal_title：Molecular and cellular endocrinology

authors： Gerard CM,Lefort A,Libert F,Christophe D,Dumont JE,Vassart G

更新日期：1988-12-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is expressed after birth in the ovary in the granulosa cells of healthy, small growing follicles. We have shown that AMH affects two important regulatory steps during folliculogenesis. At initial recruitment, AMH inhibits recruitment of primordial follicles into the growing pool, while at ...

journal_title：Molecular and cellular endocrinology

authors： Gruijters MJ,Visser JA,Durlinger AL,Themmen AP

更新日期：2003-12-15 00:00:00

abstract：:Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex. In control guinea pigs, a number of morphologic differences distinguished the ZF from the ZR, including the presence of far m...

journal_title：Molecular and cellular endocrinology

authors： Yuan BB,Tchao R,Funae Y,Voigt JM,Colby HD

更新日期：1998-11-25 00:00:00

abstract：:In the presence of retinoic acid (RA), F9 murine teratocarcinoma cells differentiate into cells resembling the extra-embryonic endoderm of the early mouse embryo. Using differential hybridization, we have cloned and characterized six cDNAs corresponding to mRNAs that exhibit reduced expression in F9 cells following RA...

journal_title：Molecular and cellular endocrinology

authors： Faria TN,LaRosa GJ,Wilen E,Liao J,Gudas LJ

更新日期：1998-08-25 00:00:00

abstract：:The cell line MD-IGF-1, containing an ovine IGF-1 cDNA driven by the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter, was used to study expression of IGF-1 linked to the MMTV-LTR in bovine mammary epithelial cells in response to various hormonal and substratum stimuli. Acute sensitivity of the MMTV-...

journal_title：Molecular and cellular endocrinology

authors： Romagnolo D,Akers RM,Wong EA,Boyle PL,McFadden TB,Byatt JC,Turner JD

更新日期：1993-10-01 00:00:00

abstract：:The first exon of the human androgen receptor (AR) contains a translated CAG (poly-glutamine) repeat. The repeat length is polymorphic in the normal population ranging from 8 to 35 repeats. Expansions to over 40 repeats lead to spinal bulbar muscular atrophy (SBMA), a late onset neurodegenerative disease. The repeat i...

journal_title：Molecular and cellular endocrinology

authors： Ferro P,Catalano MG,Dell'Eva R,Fortunati N,Pfeffer U

更新日期：2002-07-31 00:00:00

abstract：:Steroidogenic activity in the mature corpus luteum of most mammals depends upon provision of cholesterol from the circulating lipoproteins. In cattle, as in many species, high-density lipoprotein (HDL) is the major lipoprotein involved. The recent identification of the scavenger receptor SR-BI as an HDL-receptor allow...

journal_title：Molecular and cellular endocrinology

authors： Rajapaksha WR,McBride M,Robertson L,O'Shaughnessy PJ

更新日期：1997-10-31 00:00:00

abstract：:We examined the effects of growth hormone (GH), prolactin (PRL) and insulin-like growth factor-I (IGF-I) on DNA synthesis, and insulin-like growth factor binding protein 3 (IGFBP-3) gene expression, in a rat beta-cell line INS-1. GH and PRL were equally effective in increasing DNA synthesis and IGFBP-3 gene expression...

journal_title：Molecular and cellular endocrinology

authors： De W,Bréant B,Czernichow P,Asfari M

更新日期：1995-10-30 00:00:00

abstract：:The insulinotropic effects of alpha-ketoisocaproic acid and glucose reveal many common characteristics in vivo and in vitro. They qualify as initiators of insulin release, their action is amplified by potentiators of insulin release, and they have a similar potency at equimolar concentrations. The dynamics of insulin ...

journal_title：Molecular and cellular endocrinology

authors： Schauder P,McIntosh C,Schindler B,Panten U,Frerichs H

更新日期：1978-06-01 00:00:00

abstract：:HE6 (GPR64) is a highly conserved, tissue-specific heptahelical receptor of the human epididymis. The seven transmembrane (TM7) domains are a hallmark of G-protein-coupled receptors (GPCRs) which have a proven history of being excellent therapeutic targets. Of all currently marketed drugs, >30% are modulators of speci...

journal_title：Molecular and cellular endocrinology

authors： Kirchhoff C,Obermann H,Behnen M,Davies B

更新日期：2006-05-16 00:00:00

abstract：:This report represents the joint efforts of three laboratories, one with a primary interest in understanding regulatory processes in the epididymal epithelium (TTT) and two with a primary interest in identifying and characterizing new contraceptive targets (DSJ and SAJ). We have developed a highly refined mouse epidid...

journal_title：Molecular and cellular endocrinology

authors： Turner TT,Johnston DS,Jelinsky SA

更新日期：2006-05-16 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00

abstract：:This study examines the effect of FSH, testosterone and estradiol on testicular LH receptors and in vitro testicular responsiveness to LH in immature rats under various conditions. FSH treatment of 15-day-old immature rats significantly increased the number of LH receptors but did not alter testicular responsiveness. ...

journal_title：Molecular and cellular endocrinology

authors： Chen YD,Shaw MJ,Payne AH

更新日期：1977-10-01 00:00:00

abstract：:Increasing evidence in recent years has demonstrated the regulatory effects of arachidonic acid and its metabolites on steroid hormone production in various steroidogenic tissues. In trophic hormone-stimulated steroidogenesis, arachidonic acid is rapidly released from phospholipids. This release is dependent upon horm...

journal_title：Molecular and cellular endocrinology

authors： Wang X,Stocco DM

更新日期：1999-12-20 00:00:00

abstract：:Effects of human retinoid X receptor alpha (hRXR alpha) and its ligand, 9-cis-retinoic acid, on T3-mediated auto-regulation of hTR beta 1 gene expression were examined using a chloramphenicol acetyltransferase (CAT) reporter system, and a deletional analysis of the promoter. hRXR alpha enhanced T3-dependent CAT induct...

journal_title：Molecular and cellular endocrinology

authors： Sakurai A,Suzuki S,Katai M,Miyamoto T,Kobayashi H,Nakajima K,Ichikawa K,DeGroot LJ,Hashizume K

更新日期：1995-04-28 00:00:00

abstract：:We recently cloned and sequenced two kilobases of the upstream flanking region of the mouse tissue transglutaminase gene. Transfection experiments showed that this region of the transglutaminase flanking sequence was sufficient to mediate a 4-fold induction in reporter gene expression by retinoic acid. The goal of the...

journal_title：Molecular and cellular endocrinology

authors： Yan ZH,Noonan S,Nagy L,Davies PJ,Stein JP

更新日期：1996-07-01 00:00:00

abstract：:The LHRH receptor in alpha T3-1 gonadotrope cells was shown to bring about a marked and sustained activation of MAP kinase. This response was prevented by protein kinase C inhibition or down-regulation and could be partially mimicked by phorbol ester. Additional evidence for inhibition of this response by pertussis to...

journal_title：Molecular and cellular endocrinology

authors： Sim PJ,Wolbers WB,Mitchell R

更新日期：1995-08-11 00:00:00

abstract：:Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation emb...

journal_title：Molecular and cellular endocrinology

authors： You JL,Wang W,Tang MY,Ye YH,Liu AX,Zhu YM

更新日期：2018-07-15 00:00:00

abstract：:We investigated the involvement of protein synthesis in the stimulatory action of thyroid hormones on amino acid accumulation and characterized K(+) currents involved in the hyperpolarizing effect of thyroxine (T(4)) on Sertoli cells. Immature rat testes were incubated in Krebs Ringer-bicarbonate buffer (KRb) in the p...

journal_title：Molecular and cellular endocrinology

authors： Menegaz D,Zamoner A,Royer C,Leite LD,Bortolotto ZA,Silva FR

更新日期：2006-02-26 00:00:00

abstract：:Calcium homeostasis refers to the regulation of calcium ion concentration in the body. This concentration is tightly controlled by a stabilizing system consisting of calcium channels and calcium buffering proteins. Calcium homeostasis is crucial for cell survival. Various forms of cell death (e.g., necrosis and apopto...

journal_title：Molecular and cellular endocrinology

authors： Ahn C,An BS,Jeung EB

更新日期：2015-09-05 00:00:00