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Anti-Müllerian hormone and its role in ovarian function.

Abstract：

:Anti-Müllerian hormone (AMH) is expressed after birth in the ovary in the granulosa cells of healthy, small growing follicles. We have shown that AMH affects two important regulatory steps during folliculogenesis. At initial recruitment, AMH inhibits recruitment of primordial follicles into the growing pool, while at cyclic recruitment AMH lowers the FSH-sensitivity of follicles. In these ways, AMH plays an important role in regulation of ovarian follicle growth. AMH serum level is a strong candidate marker for ovarian reserve in women. In normo-ovulatory women, AMH serum levels correlated strongly with the number of antral follicles. In addition, AMH is a strong predictor for the number of oocytes retrieved in patients undergoing IVF treatment. The convenience of determination and its relative stable expression during the menstrual cycle indicate that further validation of the use of serum AMH is recommended as a clinical measure of ovarian reserve.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Gruijters MJ,Visser JA,Durlinger AL,Themmen AP

doi

10.1016/j.mce.2003.09.024

keywords:

subject

Has Abstract

pub_date

2003-12-15 00:00:00

pages

85-90

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303720703003265

journal_volume

211

pub_type

杂志文章

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