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Neurotransmitter receptors as signaling platforms in anterior pituitary cells.

Abstract：

:The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmitters in neuronal cells and their receptors are termed as neurotransmitter receptors. Most information about pituitary neurotransmitter receptors was obtained from secretory studies, RT-PCR analyses of mRNA expression and immunohistochemical and biochemical analyses, all of which were performed using a mixed population of pituitary cells. However, recent electrophysiological and imaging experiments have characterized γ-aminobutyric acid-, acetylcholine-, and ATP-activated receptors and channels in single pituitary cell types, expanding this picture and revealing surprising differences in their expression between subtypes of secretory cells and between native and immortalized pituitary cells. The main focus of this review is on the electrophysiological and pharmacological properties of these receptors and their roles in calcium signaling and calcium-controlled hormone secretion.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Zemková H,Stojilkovic SS

doi

10.1016/j.mce.2017.07.003

subject

Has Abstract

pub_date

2018-03-05 00:00:00

pages

49-64

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30357-X

journal_volume

463

pub_type

杂志文章,评审

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