Transcriptional regulation of the thyroperoxydase gene by thyrotropin and forskolin.

abstract：:Tumor necrosis factor-alpha (TNF-alpha) was found to induce type-1 plasminogen activator inhibitor (PAI-1) antigen in the human fibrosarcoma cell line HT-1080, and PAI-1 and urokinase-type plasminogen activator (u-PA) antigens in the human carcinoma cell line T-CAR1; tissue-type plasminogen activator (t-PA) antigen wa...

journal_title：Molecular and cellular endocrinology

authors： Georg B,Helseth E,Lund LR,Skandsen T,Riccio A,Danø K,Unsgaard G,Andreasen PA

更新日期：1989-01-01 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:Pituitary and plasma pools from postmenopausal women and plasma pools from women at midcycle were fractionated by electrofocusing in sucrose density gradients. The biological LH activity was determined in each of the electrofocusing fractions by the use of an in vitro bioassay method. A heterogeneous profile of LH act...

journal_title：Molecular and cellular endocrinology

authors： Robertson DM,Van Damme MP,Diczfalusy E

更新日期：1977-11-01 00:00:00

abstract：:Transcription of the glycoprotein hormone alpha-subunit gene in the pituitary is governed by different promoter elements in thyrotropes and gonadotropes. We recently identified an upstream enhancer that directs a high level of cell type specific expression in transgenic mice and stimulates proximal promoter activity i...

journal_title：Molecular and cellular endocrinology

authors： Wood WM,Dowding JM,Sarapura VD,McDermott MT,Gordon DF,Ridgway EC

更新日期：1998-07-25 00:00:00

abstract：:The CYP11A1 gene encodes cytochrome P450scc, the enzyme catalyzing the first step of steroid biosynthesis in the adrenal and gonad. We generated transgenic mice containing 2.3 kb of the 5'-flanking region of CYP11A1 driving LacZ reporter gene expression, in order to study hormonal control of CYP11A1 gene expression in...

journal_title：Molecular and cellular endocrinology

authors： Huang Y,Hu M,Hsu N,Wang CL,Chung B

更新日期：2001-04-25 00:00:00

abstract：:Wilms' tumour is a childhood kidney cancer, and a classic example of cancer arising through disrupted development (Armstrong et al., 1992). It is one of the most common solid paediatric malignancies, affecting one in 10000 children. The genetics of Wilms' tumour is complicated, with several different genes or chromoso...

journal_title：Molecular and cellular endocrinology

authors： Schedl A,Hastie N

更新日期：1998-05-25 00:00:00

abstract：:Aggresome formation, a cellular response to misfolded protein aggregates, is linked to cancer and neurodegenerative disorders. Previously we showed that Gag-v-ErbA (v-ErbA), a retroviral variant of the thyroid hormone receptor (TRα1), accumulates in and sequesters TRα1 into cytoplasmic foci. Here, we show that foci re...

journal_title：Molecular and cellular endocrinology

authors： Bondzi C,Brunner AM,Munyikwa MR,Connor CD,Simmons AN,Stephens SL,Belt PA,Roggero VR,Mavinakere MS,Hinton SD,Allison LA

更新日期：2011-01-30 00:00:00

abstract：:Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration mo...

journal_title：Molecular and cellular endocrinology

authors： Chen L,Zhao Y,Li L,Xie L,Chen X,Liu J,Li X,Jin L,Li X,Ge RS

更新日期：2018-10-15 00:00:00

abstract：:Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant role in the progression of human prostate cancer (PCa), which is associated with heterogeneity of SSRs expression and specific cell localization as we already demonstrated in the LNCaP cell line, an in vitro model of hu...

journal_title：Molecular and cellular endocrinology

authors： Ruscica M,Magni P,Steffani L,Gatto F,Albertelli M,Rametta R,Valenti L,Ameri P,Magnaghi V,Culler MD,Minuto F,Ferone D,Arvigo M

更新日期：2014-02-15 00:00:00

abstract：:Adiponectin, an adipose-secreted adipocytokine, exhibits various metabolic functions but has no known effect on bone development through the growth plate and specifically, in chondrocytes. Using the mouse ATDC5 cell line, a widely used in vitro model of chondrogenesis, we demonstrated the expression of adiponectin and...

journal_title：Molecular and cellular endocrinology

authors： Challa TD,Rais Y,Ornan EM

更新日期：2010-07-29 00:00:00

abstract：:The signal transducers and activators of transcriptions (Stats) are central mediators of cytokine responses especially in hematopoietic cells. The detailed molecular mechanisms of Stat activation, particularly the role of post-translational modifications and co-operation with cellular transcription factors are subject...

journal_title：Molecular and cellular endocrinology

authors： Beisenherz-Huss C,Mundt M,Herrala A,Vihko P,Schubert A,Groner B

更新日期：2001-10-25 00:00:00

abstract：:Recently fibroblast growth factor 21 (FGF21) has been identified as a potent regulator in glucose and lipid homeostasis. Here, we firstly investigated the metabolic role of FGF21 in human liver-derived HepG2 cells, and suggested that overexpression of FGF21 suppressed triglyceride accumulation by inhibiting the transc...

journal_title：Molecular and cellular endocrinology

authors： Zhang Y,Lei T,Huang JF,Wang SB,Zhou LL,Yang ZQ,Chen XD

更新日期：2011-08-06 00:00:00

abstract：:In an effort to identify the signal transduction mechanism associated with the inhibition of juvenile hormone (JH) biosynthesis by the neuropeptides allatostatins, levels of the cyclic nucleotides cAMP and cGMP were measured in corpora allata (CA) of virgin and mated Diploptera punctata females using radioimmunoassays...

journal_title：Molecular and cellular endocrinology

authors： Cusson M,Yagi KJ,Guan XC,Tobe SS

更新日期：1992-11-01 00:00:00

abstract：:The endometrial expression of the gene encoding porcine uteroferrin (UF), during pregnancy is presumed to be mediated by cis-regulatory regions distinct from those that confer its limited expression to other mammalian tissues and cell types. In the present study, chimeric DNA constructs of native and progressive 5' de...

journal_title：Molecular and cellular endocrinology

authors： Gonzalez BY,Perera OP,Michel FJ,Simmen RC

更新日期：1995-02-27 00:00:00

abstract：:The requirement for caspases (ICE-like proteases) were investigated in mediating apoptosis of WEHI7.2 mouse lymphoma cells in response to two death inducers with different mechanisms of action, the glucocorticoid hormone dexamethasone (DX) and the calcium-ATPase inhibitor thapsigargin (TG). Apoptosis induction by thes...

journal_title：Molecular and cellular endocrinology

authors： McColl KS,He H,Zhong H,Whitacre CM,Berger NA,Distelhorst CW

更新日期：1998-04-30 00:00:00

abstract：:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

journal_title：Molecular and cellular endocrinology

authors： Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

更新日期：2015-01-05 00:00:00

abstract：:Meiosis-activating sterol (MAS) has been shown to induce mouse oocytes cultured in the presence of hypoxanthine (HX) to resume meiosis. The present research was conducted to determine whether amphotericin B or ketoconazole (a promoter and an inhibitor of production of MAS), affected oocyte maturation. Mouse cumulus ce...

journal_title：Molecular and cellular endocrinology

authors： Lu Z,Xia G,Byskov AG,Andersen CY

更新日期：2000-06-01 00:00:00

abstract：:The objective of this work was to identify the natural substrates of cyclic AMP-dependent protein kinase in pituitary cells. Studies were performed using 2 systems: intact pituitary cells stimulated with dibutyryl cyclic AMP (DBC) after preincubation with [gamma-32P]. Phosphorylation of proteins was analyzed by two-di...

journal_title：Molecular and cellular endocrinology

authors： Brattin WJ Jr,Portanova R

更新日期：1981-07-01 00:00:00

abstract：:The concentration of high-affinity estradiol binding sites in the uteri and pituitaries of normal and two dwarf strains of mice was studied. The two dwarf strains are characterized by their total absence of growth hormone or prolactin synthesis and low or absent TSH production. The uteri of the dwarf mice are small bu...

journal_title：Molecular and cellular endocrinology

authors： Sartor P,Slabaugh M,Sakai D,Gorski J

更新日期：1983-01-01 00:00:00

abstract：:This study evaluated the levels and the enzymatic characteristics of 11beta-hydroxysteroid dehydrogenase activity (11beta-HSD) of chorionic villi isolated from first trimester human placenta. The results demonstrated a predominant expression of the NAD-dependent dehydrogenase isoform (11beta-HSD2) over the NADP-depend...

journal_title：Molecular and cellular endocrinology

authors： Arcuri F,Sestini S,Paulesu L,Bracci L,Carducci A,Manzoni F,Cardone C,Cintorino M

更新日期：1998-06-25 00:00:00

abstract：:If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the in...

journal_title：Molecular and cellular endocrinology

authors： Delvenne P,Herman L,Kholod N,Caberg JH,Herfs M,Boniver J,Jacobs N,Hubert P

更新日期：2007-01-29 00:00:00

abstract：:Using as a model system, primary cultures of porcine Leydig cells, we have shown that transforming growth factor-beta 1 (TGF-beta 1) (2 ng/ml, 72 h) antagonizes the stimulatory action of insulin-like growth factor-I (IGF-I) on luteinizing hormone (LH/hCG) receptors. We therefore investigated the action of TGF-beta 1 o...

journal_title：Molecular and cellular endocrinology

authors： Besset V,Collette J,Chauvin MA,Franchimont P,Benahmed M

更新日期：1994-03-01 00:00:00

abstract：:The availability of regulatory sequences directing tissue-specific expression of transgenes in genetically modified mice and large animals is a prerequisite for the development of adequate models for human diseases. The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic beta-...

journal_title：Molecular and cellular endocrinology

authors： Grzech M,Dahlhoff M,Herbach N,Habermann FA,Renner-Müller I,Wanke R,Flaswinkel H,Wolf E,Schneider MR

更新日期：2010-02-05 00:00:00

abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

journal_title：Molecular and cellular endocrinology

authors： Ananthanarayanan VS,Kerman A

更新日期：2006-02-26 00:00:00

abstract：:We have shown that somatostatin agonist peptide CH275, selective to somatostatin receptor (sst) subtypes 1,4, was more effective in preventing intimal hyperplasia than the sst2,3,5-selective octreotide, raising the question what are the separate roles of the sst1- and 4-subtypes. Here, we dissect this observation furt...

journal_title：Molecular and cellular endocrinology

authors： Tigerstedt NM,Aavik E,Aavik S,Savolainen-Peltonen H,Hayry P

更新日期：2007-12-15 00:00:00

abstract：:Modifications of tRNAs in various physiological or experimental conditions are well documented. We have compared isoacceptor tRNAs extracted from target organs (heart and liver) from thyroidectomized rats to those of control animals. Nine liver aminoacyl-tRNAs and eight heart aminoacyl-tRNAs from thyroidectomized and ...

journal_title：Molecular and cellular endocrinology

authors： Kessous C,Befort JJ,Befort N,Benmiloud M

更新日期：1983-02-01 00:00:00

abstract：:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

journal_title：Molecular and cellular endocrinology

authors： Li R,Cui J,Shen Y

更新日期：2014-05-25 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) stimulates maximally both the release of previously synthesized prolactin and the de novo synthesis of prolactin by GH4C1 rat pituitary cells at concentrations less than those necessary to fully occupy the TRH receptor at equilibrium. We have examined the dependency of maximal TRH-e...

journal_title：Molecular and cellular endocrinology

authors： Ramsdell JS,Tashjian AH Jr

更新日期：1985-12-01 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) receptor is expressed in extrathyroidal tissues such as hepatocytes, adipocytes, and skeletal muscle, which suggests a possible novel role of TSH in various metabolic processes in extrathyroidal tissues independent of thyroid hormones. We investigated whether TSH has any effects on gl...

journal_title：Molecular and cellular endocrinology

authors： Moon MK,Kang GH,Kim HH,Han SK,Koo YD,Cho SW,Kim YA,Oh BC,Park do J,Chung SS,Park KS,Park YJ

更新日期：2016-11-15 00:00:00

abstract：:The binding of thyrotropin (TSH) to the TSH receptor (TSHR) activates two signaling pathways: the cAMP-protein kinase A (PKA) and the protein kinase C (PKC) systems. We have recently demonstrated that TSH activates the Janus kinases (JAK)/signal transducer and activator of transcription (STAT) pathway via TSHR. This s...

journal_title：Molecular and cellular endocrinology

authors： Park YJ,Park ES,Kim MS,Kim TY,Lee HS,Lee S,Jang IS,Shong M,Park DJ,Cho BY

更新日期：2002-08-30 00:00:00