Abstract：
:The concentration of high-affinity estradiol binding sites in the uteri and pituitaries of normal and two dwarf strains of mice was studied. The two dwarf strains are characterized by their total absence of growth hormone or prolactin synthesis and low or absent TSH production. The uteri of the dwarf mice are small but the receptor concentration per unit of DNA was similar to the normals. Nuclear and cytoplasmic distribution studies and saturation analysis detected no differences in receptor characteristics between dwarf and normal mice. These results demonstrate that prolactin, growth hormone and TSH do not control the developmental increase in uterine estrogen receptor that normally occurs in the young mouse. The concentration of estrogen receptor per unit of DNA in the pituitaries of the dwarfs was only 20-30% of normal animals of the same strain. This suggests that estrogen receptor in the mouse pituitary is associated to a great extent with lactotrophs and/or somatotrophs which are absent in the dwarfs.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Sartor P,Slabaugh M,Sakai D,Gorski Jdoi
10.1016/0303-7207(83)90007-2subject
Has Abstractpub_date
1983-01-01 00:00:00pages
91-9issue
1eissn
0303-7207issn
1872-8057journal_volume
29pub_type
杂志文章abstract：:The activity of the two cAMP-dependent protein kinases (PKa I and PKa II) was evaluated in dog thyroid cells in primary cultures after a 6-day growth period induced by either thyrotropin (TSH) or epidermal growth factor (EGF). Although the total PKa activity was not affected in cells cultured in the presence of TSH or...
journal_title：Molecular and cellular endocrinology
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更新日期：1981-10-01 00:00:00
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journal_title：Molecular and cellular endocrinology
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更新日期：2008-08-13 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：1989-03-01 00:00:00
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journal_title：Molecular and cellular endocrinology
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更新日期：2006-04-25 00:00:00
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更新日期：2001-02-14 00:00:00
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journal_title：Molecular and cellular endocrinology
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更新日期：2009-12-10 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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更新日期：2013-09-25 00:00:00
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pub_type： 杂志文章
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更新日期：1997-08-08 00:00:00
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
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更新日期：1979-04-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(89)90064-6
更新日期：1989-06-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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更新日期：1981-01-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.mce.2017.10.019
更新日期：2018-05-15 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/j.mce.2004.02.015
更新日期：2004-10-15 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/s0303-7207(98)00054-9
更新日期：1998-03-16 00:00:00
