Abstract:
:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be synthesized by neurons, but also by astrocytes. Brain estrogen also works locally at the site of synthesis in paracrine and/or intracrine fashion to maintain important tissue-specific functions. Here, we will focus on the biology of brain estrogen and its impact on cognitive function and Alzheimer's disease. This comprehensive review provides new insights into brain estrogens by presenting a better understanding of the tissue-specific estrogen effects and their roles in healthy ageing and cognitive function.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Li R,Cui J,Shen Ydoi
10.1016/j.mce.2013.12.018subject
Has Abstractpub_date
2014-05-25 00:00:00pages
13-21issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(14)00008-2journal_volume
389pub_type
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
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doi:10.1016/0303-7207(85)90041-3
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journal_title:Molecular and cellular endocrinology
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2018.01.024
更新日期:2018-09-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(95)03489-t
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journal_title:Molecular and cellular endocrinology
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更新日期:2003-01-31 00:00:00
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journal_title:Molecular and cellular endocrinology
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doi:10.1016/j.mce.2008.06.019
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更新日期:2010-05-28 00:00:00
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doi:10.1016/0303-7207(95)03483-n
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:2001-06-10 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:2019-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mce.2019.110698
更新日期:2020-03-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2015.02.006
更新日期:2015-04-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2005.04.003
更新日期:2005-06-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(91)90032-n
更新日期:1991-12-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.mce.2010.04.025
更新日期:2010-11-25 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:1998-10-25 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/j.mce.2004.02.015
更新日期:2004-10-15 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
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更新日期:1998-05-25 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/s0303-7207(02)00374-x
更新日期:2002-12-30 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章
doi:10.1016/0303-7207(91)90263-r
更新日期:1991-04-01 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.mce.2009.08.015
更新日期:2010-04-29 00:00:00
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journal_title:Molecular and cellular endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.mce.2010.07.015
更新日期:2011-01-15 00:00:00