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Upstream open reading frames regulate cannabinoid receptor 1 expression under baseline conditions and during cellular stress.

Abstract：

:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the five known mRNA variants of the human CNR1 gene revealed that two of these variants contain upstream open reading frames that are able to modulate gene expression both under baseline condition and conditions of cellular stress including hypoxia, glucose restriction and hyperthermia. The upstream open reading frames might provide a mechanism that enables the cannabinoid 1 receptor to escape the general repression of protein synthesis that is typical for conditions of cellular stress.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

doi

10.1016/j.mce.2014.09.019

subject

Has Abstract

pub_date

2015-01-05 00:00:00

pages

103-9

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00299-8

journal_volume

399

pub_type

杂志文章

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