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Role of androgens in the ovary.

Abstract：

:It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor. The creation and analysis of genetic mouse models with global and cell-specific disruption of the Ar gene, the sole mediator of pure androgenic action, has now allowed the elucidation of a role for AR-mediated androgen actions in the regulation of normal and pathological ovarian function. This review aims to summarize findings from clinical, animal, pharmacological and novel genetic AR mouse models to provide an understanding of the important roles androgens play in the ovary, as well as providing insights into the human implications of these roles.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Walters KA,Handelsman DJ

doi

10.1016/j.mce.2017.06.026

subject

Has Abstract

pub_date

2018-04-15 00:00:00

pages

36-47

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30353-2

journal_volume

465

pub_type

杂志文章,评审

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