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The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.

Abstract：

:Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP-dependent chromatin remodeling complex SWI/SNF in RAR-mediated transcription. Here we demonstrate that two highly related subunits of the core SWI/SNF complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for RARs. This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Flajollet S,Lefebvre B,Cudejko C,Staels B,Lefebvre P

doi

10.1016/j.mce.2007.02.004

subject

Has Abstract

pub_date

2007-05-30 00:00:00

pages

23-32

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(07)00077-9

journal_volume

270

pub_type

杂志文章

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