当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > The circadian clock and glucocorticoids--interactions across many time scales.

The circadian clock and glucocorticoids--interactions across many time scales.

Abstract：

:Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a daytime dependent fashion. In addition, in many species seasonal changes in basal glucocorticoid levels have been reported. In their target tissues, glucocorticoids bind to cytoplasmic receptors of the nuclear receptor superfamily. Upon binding, these receptors regulate transcription in a highly dynamic fashion, which involves stochastic binding to regulatory DNA elements on a time scale of seconds and heat shock protein mediated receptor-ligand complex recycling within minutes. The glucocorticoid hormone system interacts with another highly dynamic system, the circadian clock. The circadian clock is an endogenous biological timing mechanism that allows organisms to anticipate regular daily changes in their environment. It regulates daily rhythms of glucocorticoid release by a variety of mechanisms, modulates glucocorticoid signaling and is itself influenced by glucocorticoids. Here, we discuss mechanisms, functions and interactions of the circadian and glucocorticoid systems across time scales ranging from seconds (DNA binding by transcriptional regulators) to years (seasonal rhythms).

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Dickmeis T,Weger BD,Weger M

doi

10.1016/j.mce.2013.05.012

subject

Has Abstract

pub_date

2013-11-05 00:00:00

pages

2-15

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(13)00216-5

journal_volume

380

pub_type

杂志文章,评审

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Transplantation of primary bovine adrenocortical cells into scid mice.

    abstract：:Bovine adrenocortical cells were transplanted into scid mice, using a small cylinder inserted beneath the kidney capsule. The tissue formed from primary bovine adrenocortical cells replaced the essential functions of the animals' own adrenal glands, which were removed during the cell transplantation procedure. Most ad...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00070-2

    authors： Thomas M,Hornsby PJ

    更新日期：1999-07-20 00:00:00

  • Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets.

    abstract：:Insulin secretion from MIN6 cells configured as cell aggregates by culture on a gelatin substrate (pseudoislets) is enhanced compared to that of MIN6 cells grown as monolayers on tissue culture plastic, indicating the importance of beta-cell-to-beta-cell proximity for insulin release. In this study we have shown that ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00051-5

    authors： Hauge-Evans AC,Squires PE,Belin VD,Roderigo-Milne H,Ramracheya RD,Persaud SJ,Jones PM

    更新日期：2002-06-14 00:00:00

  • Empagliflozin improves primary haemodynamic parameters and attenuates the development of atherosclerosis in high fat diet fed APOE knockout mice.

    abstract：:The effects of long-term treatment with empagliflozin on biochemical and immunohistochemical markers related to atherosclerosis and atherosclerosis development in the aorta of apolipoprotein E knockout [Apo-E (-/-)] mice were evaluated in this study. Empagliflozin-treated mice had lower total cholesterol (P < 0.05), f...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2019.110487

    authors： Dimitriadis GK,Nasiri-Ansari N,Agrogiannis G,Kostakis ID,Randeva MS,Nikiteas N,Patel VH,Kaltsas G,Papavassiliou AG,Randeva HS,Kassi E

    更新日期：2019-08-20 00:00:00

  • Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity.

    abstract：:Pasireotide has been associated with tumor shrinkage in patients with Cushing's disease subjected to long term treatment. However, to date the implicated molecular mechanisms are poorly elucidated. Here, we tested pasireotide-mediated cytostatic and cytotoxic effects in ACTH-secreting primary tumor cultures and murine...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.12.022

    authors： Treppiedi D,Giardino E,Catalano R,Mangili F,Vercesi P,Sala E,Locatelli M,Arosio M,Spada A,Mantovani G,Peverelli E

    更新日期：2019-03-01 00:00:00

  • Effects of cyclic AMP elevation on the levels of insulin receptors in glial C6 cells.

    abstract：:The regulation of the insulin receptor by cAMP has been examined in glial C6 cells. Incubation for 48 h with dibutyryl cyclic AMP produced a dose-dependent inhibition of 125I-insulin binding to the cells. Other agents that elevate intracellular cAMP levels such as forskolin and cholera toxin mimicked the effect of thi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90127-5

    authors： Montiel F,Aranda A,Pascual A

    更新日期：1989-02-01 00:00:00

  • Characterization of complementary deoxyribonucleic acids encoding preprogalanin and its alternative splice variants in the goldfish.

    abstract：:This paper reports the identification of five preprogalanin complementary deoxyribonucleic acids encoding preprogalanin peptides in the goldfish. Preprogalanin 1A, 1B and 1C are encoded in galanin gene 1 and 2A and 2B are encoded in gene 2. Preprogalanin 1B and 2B have a 24 amino acids insert in the mature peptide reg...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00301-5

    authors： Unniappan S,Lin X,Peter RE

    更新日期：2003-02-28 00:00:00

  • Responses of Y1 adrenocortical tumor cells to o-nitrophenyl sulfenyl ACTH.

    abstract：:NPS(o-nitrophenyl sulfenyl)-ACTH stimulated steroidogenesis in Y1 cells to the same maximum level as did ACTH, but with a 60-fold lower potency than the native hormone. NPS-ACTH also stimulated the extracellular accumulation of cAMP in Y1 cells with lower potency than the unmodified hormone. The amount of cAMP accumul...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(80)90111-2

    authors： Rae PA,Zinman H,Ramachandran J,Schimmer BP

    更新日期：1980-03-01 00:00:00

  • Nitric oxide-dependent activation of pig oocytes: role of calcium.

    abstract：:Pig oocytes matured in vitro are parthenogenetically activated after treatment with nitric oxide (NO)-donor SNAP. The chelation of intracellular calcium ions with BAPTA-AM suppressed the SNAP-induced activation in a dose-dependent manner. Activation by a NO-donor is dependent on the influx of calcium from extracellula...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.05.004

    authors： Petr J,Rajmon R,Lánská V,Sedmíková M,Jílek F

    更新日期：2005-10-20 00:00:00

  • The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.

    abstract：:Members of the dual specificity tyrosine phosphorylated and regulated kinase family (Dyrk) were shown to have a highly testis-abundant or testis-restricted expression pattern. Furthermore, for some members of the family an involvement in gene expression regulation by phosphorylating transcription factors has been show...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.12.041

    authors： Sacher F,Möller C,Bone W,Gottwald U,Fritsch M

    更新日期：2007-03-15 00:00:00

  • An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells.

    abstract：:Individual variation in sensitivity to glucocorticoids (GCs) poses a dilemma to the clinician. Currently available assays to determine individual sensitivity to GCs either seem imprecise, or they are based on mitogen-activated lymphocytes, although mitogens themselves may affect cellular GC sensitivity. To avoid these...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.12.011

    authors： Vermeer H,Hendriks-Stegeman BI,van Suylekom D,Rijkers GT,van Buul-Offers SC,Jansen M

    更新日期：2004-04-15 00:00:00

  • The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.

    abstract：:The luteinizing hormone receptor (LHR), one of the three glycoprotein hormone receptors, is necessary for critical reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation, and male sex differentiation. Moreover, it has been postulated to contribute to certain neoplasms, particularly ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.04.025

    authors： Puett D,Angelova K,da Costa MR,Warrenfeltz SW,Fanelli F

    更新日期：2010-11-25 00:00:00

  • Intracellular processing of growth hormone receptors by adipocytes in primary culture.

    abstract：:Rat adipocytes in primary culture have been used to study the intracellular processing of growth hormone (GH) receptors. Pretreatment of adipocytes with 20 micrograms/ml cycloheximide resulted in a rapid decline (t1/2 approximately 45 min) of the 125I-human growth hormone (hGH) binding capacity of the cells. This decl...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90037-8

    authors： Roupas P,Herington AC

    更新日期：1988-05-01 00:00:00

  • A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes.

    abstract：:The defining characteristic of obesity is increased adipose tissue (AT) mass following chronic positive energy supply. AT mass is determined by adipocyte number and size, which reflect proliferation and differentiation of preadipocytes and hypertrophy of pre-existing adipocytes. The molecular pathways governing AT exp...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.04.012

    authors： Hutley LJ,Newell FS,Kim YH,Luo X,Widberg CH,Shurety W,Prins JB,Whitehead JP

    更新日期：2011-06-06 00:00:00

  • Low concentrations of Bisphenol A and para-Nonylphenol affect extravillous pathway of human trophoblast cells.

    abstract：:Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed countries. In this study, human trophoblast cells HTR-8/SVneo w...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.05.023

    authors： Spagnoletti A,Paulesu L,Mannelli C,Ermini L,Romagnoli R,Cintorino M,Ietta F

    更新日期：2015-09-05 00:00:00

  • Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.

    abstract：:The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.08.009

    authors： Qi H,Grenier J,Fournier A,Labrie C

    更新日期：2003-11-28 00:00:00

  • Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling.

    abstract：:Vitamin D is a key factor for calcium and bone homeostasis, but signalling through the vitamin D receptor (VDR) seems also to be important for testicular function. To test the functional role of vitamin D signalling we examined the male reproductive system of the Leuven Vdr-ablated (Vdr(-/-)) mice, previously establis...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.06.036

    authors： Blomberg Jensen M,Lieben L,Nielsen JE,Willems A,Jørgensen A,Juul A,Toppari J,Carmeliet G,Rajpert-De Meyts E

    更新日期：2013-09-05 00:00:00

  • Enhanced activity of the cardiac endocrine system during right ventricular hypertrophy.

    abstract：:In a model of pulmonary hypertension induced by a single injection of monocrotaline (MCT), we observed a time-dependent right ventricular hypertrophy, which became apparent in treated rats 21 days after administration of MCT and progressed through day 45. Associated with this right ventricular hypertrophy were time-de...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90011-7

    authors： Oehlenschlager WF,Kurtz DT,Baron DA,Currie MG

    更新日期：1989-04-01 00:00:00

  • Electrophysiological test of an amphiphilic beta-structure in LHRH action.

    abstract：:Micropipettes were used to record electrical activity from single neurons in hypothalamic tissue slices, in the hypothalamic arcuate nucleus (ARC), and in the periventricular and suprachiasmatic preoptic nuclei (POA). Responses were measured following in vitro application of luteinizing hormone releasing hormone (LHRH...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90038-9

    authors： Pan JT,Kow LM,Kendall DA,Kaiser ET,Pfaff DW

    更新日期：1986-12-01 00:00:00

  • The actions of forskolin, cholera toxin and iloprost on casein secretion by lactating doe mammary glands.

    abstract：:The secretagogue effects of prolactin (PRL) and of various agents acting on cAMP levels, forskolin, cholera toxin and iloprost (a stable analogue of prostaglandin I2) have been assessed in lactating doe mammary gland fragments in vitro. Forskolin (10 microM), cholera toxin (1 microgram/ml) and iloprost (10 mM) stimula...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90161-5

    authors： Ollivier-Bousquet M

    更新日期：1989-08-01 00:00:00

  • The IGF system during fetal-placental development of the mouse.

    abstract：:Insulin-like growth factors (IGF-I and -II) promote cellular mitosis and differentiation and have been implicated in fetal and placental growth. Together with the IGF receptors and IGF binding proteins (IGFBPs) they form a complex network, with tissue specific activity. This review will discuss the data generated to e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(98)00041-0

    authors： van Kleffens M,Groffen C,Lindenbergh-Kortleve DJ,van Neck JW,González-Parra S,Dits N,Zwarthoff EC,Drop SL

    更新日期：1998-05-25 00:00:00

  • Fatty acid flux in adipocytes: the in's and out's of fat cell lipid trafficking.

    abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2009.08.015

    authors： Thompson BR,Lobo S,Bernlohr DA

    更新日期：2010-04-29 00:00:00

  • The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma.

    abstract：:The objective of this study was to analyze the correlation between matrix metalloproteinases (MMPs) and angiogenic genes and survival in advanced-stage ovarian carcinomas. Primary and metastatic ovarian carcinomas from patients diagnosed with FIGO stage III-IV disease and followed up to 20 years were studied using mRN...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00709-2

    authors： Davidson B,Goldberg I,Gotlieb WH,Kopolovic J,Ben-Baruch G,Nesland JM,Reich R

    更新日期：2002-02-22 00:00:00

  • The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.

    abstract：:The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.08.004

    authors： Marotta P,Amendola E,Scarfò M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

    更新日期：2014-10-01 00:00:00

  • Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.

    abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2012.08.020

    authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

    更新日期：2013-01-05 00:00:00

  • 17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis.

    abstract：:17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00416-0

    authors： Breitling R,Krazeisen A,Möller G,Adamski J

    更新日期：2001-01-22 00:00:00

  • GnRH-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion.

    abstract：:In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1-5). GnRH-(1-5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1-5) acts on the orphan G protein-coupled...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.08.010

    authors： Cho-Clark M,Larco DO,Zahn BR,Mani SK,Wu TJ

    更新日期：2015-11-05 00:00:00

  • c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction.

    abstract：:Thrombin and COX-2 regulating cardiac hypertrophy are via various signaling cascades. Several transcriptional factors including CREB involve in COX-2 expression. However, the interplay among thrombin, CREB, and COX-2 in primary human neonatal ventricular cardiomyocytes remains unclear. In this study, thrombin-induced ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.04.005

    authors： Chien PT,Lin CC,Hsiao LD,Yang CM

    更新日期：2015-07-05 00:00:00

  • A synthetic peptide corresponding to amino acids 9-30 of the extracellular domain of the follitropin (FSH) receptor specifically binds FSH.

    abstract：:As deduced on the basis of cloning experiments, the putative extracellular domain of pituitary glycoprotein hormone (lutropin (LH), thyrotropin (TSH), and FSH) receptors (rec) is sufficiently large to suggest involvement in hormone binding. Comparison of the amino acid sequences of the extracellular domains of the gly...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90228-x

    authors： Dattatreyamurty B,Reichert LE Jr

    更新日期：1992-09-01 00:00:00

  • HMGA2: A pituitary tumour subtype-specific oncogene?

    abstract：:The high mobility group AT-hook (HMGA) proteins, a family of DNA architectural factors, are highly expressed during embryogenesis and play a crucial role in several different biological processes, as well as in tumorigenesis of a wide range of tissues, including pituitary. Indeed, HMGA2 has been found rearranged and a...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.03.019

    authors： Fedele M,Palmieri D,Fusco A

    更新日期：2010-09-15 00:00:00

  • Isolation and characterisation of calcineurin from adrenal cell cytoskeleton: identification of substrates for Ca2+-calmodulin-dependent phosphatase activity.

    abstract：:Ca2+-calmodulin-dependent protein phosphatase activity is found in cytoskeletons of Y-1 mouse adrenal and bovine fasciculata cells. The activity is inhibited by three inhibitors of calmodulin (trifluoperazine, W-7 and pimozide) with EC50 in the low micromolar range. Protein phosphatase activity is inhibited by vanadat...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90078-6

    authors： Papadopoulos V,Brown AS,Hall PF

    更新日期：1989-05-01 00:00:00