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Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.

Abstract：

:The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three transcripts encode different forms of the NEDD4L protein, two of which contain an N-terminal C2 domain. These transcripts were detected at high levels in human prostate and mammary gland, and at lower levels in brain and skeletal muscle. We also found that the previously described NEDD4La and NEDD4Lc (KIAA0439) transcripts are also expressed in prostate and LNCaP cells. However, only NEDD4Lf, NEDD4Lg and NEDD4Lh were up-regulated by androgen in LNCaP cells. These data provide new information on the structure and expression profile of NEDD4L-derived transcripts and identify specific isoforms of the NEDD4L ubiquitin ligase as proteins with potentially important roles in androgen action and prostate physiology.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Qi H,Grenier J,Fournier A,Labrie C

doi

10.1016/j.mce.2003.08.009

keywords:

subject

Has Abstract

pub_date

2003-11-28 00:00:00

pages

51-62

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303720703003101

journal_volume

210

pub_type

杂志文章

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