Hypoxia regulation of expression and angiogenic effects of vasoactive intestinal peptide (VIP) and VIP receptors in LNCaP prostate cancer cells.

abstract：:A large part of germ cells die apoptotically during testicular development in rodents. In the present study, a wave of germ cell apoptosis was observed between days 10 and 30 of postnatal life by in situ 3'-end labeling and DNA fragmentation analysis. To explore the potential involvement of Bcl-2 family members in thi...

journal_title：Molecular and cellular endocrinology

authors： Yan W,Suominen J,Samson M,Jégou B,Toppari J

更新日期：2000-07-25 00:00:00

abstract：:Recently fibroblast growth factor 21 (FGF21) has been identified as a potent regulator in glucose and lipid homeostasis. Here, we firstly investigated the metabolic role of FGF21 in human liver-derived HepG2 cells, and suggested that overexpression of FGF21 suppressed triglyceride accumulation by inhibiting the transc...

journal_title：Molecular and cellular endocrinology

authors： Zhang Y,Lei T,Huang JF,Wang SB,Zhou LL,Yang ZQ,Chen XD

更新日期：2011-08-06 00:00:00

abstract：:Direct roles of follicle-stimulating hormone (FSH)-suppressing protein (FSP) and activin in regulation of ovarian granulosa cell differentiation have been reported recently. The present study further investigated the effects of these peptides on steroidogenesis and inhibin production as well as cAMP generation in cult...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK

更新日期：1991-08-01 00:00:00

abstract：:LH and FSH act on gonadal cells to regulate steroidogenesis and gametogenesis. To model human reproductive disorders involving loss of LH function and to define LH-responsive genes, we produced knockout mice lacking the hormone-specific LHbeta subunit. LHbeta null mice are viable but demonstrate postnatal defects in g...

journal_title：Molecular and cellular endocrinology

authors： Kumar TR

更新日期：2007-04-15 00:00:00

abstract：:The main objective of this study was to characterize nuclear T3 and T4 binding in the developing rat brain. More specifically, we sought to determine (a) whether T3 and T4 bind to the same nuclear receptor, (b) whether there are multiple forms of nuclear T3 or T4 receptors, and (c) whether the above parameters are sim...

journal_title：Molecular and cellular endocrinology

authors： Margarity M,Matsokis N,Valcana T

更新日期：1983-08-01 00:00:00

abstract：:Human type II iodothyronine deiodinase (hDII) belongs to a family of selenoproteins. It catalyzes 5'-deiodination of thyroxine to generate an active thyroid hormone, 3,3',5-triiodothyronine. Two novel splice variants of hDII gene transcript; namely hDII-b and hDII-c, were identified. Three distinct DNA fragments (hDII...

journal_title：Molecular and cellular endocrinology

authors： Ohba K,Yoshioka T,Muraki T

更新日期：2001-02-14 00:00:00

abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

journal_title：Molecular and cellular endocrinology

authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

更新日期：1999-11-25 00:00:00

abstract：:The mechanisms of cytokine-induced beta-cell death are poorly characterised. In rat insulin-producing RINm5F cells, the combination of interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha presently induced disruption of the mitochondrial membrane potential (Deltapsi(m)) as demonstrated by reduced JC-1 ...

journal_title：Molecular and cellular endocrinology

authors： Barbu A,Welsh N,Saldeen J

更新日期：2002-04-25 00:00:00

abstract：:In the present paper the effects of 17beta-estradiol on the expression of the preprosomatostatin 1 (PSS1) in the orange-spotted grouper hypothalamus and ovary were investigated. Results from in vivo of intraperitoneal injection and in vitro static cultures showed that estradiol increased the mRNA expression of PSS1 ge...

journal_title：Molecular and cellular endocrinology

authors： Zhang L,Li W,Hong X,Lin H

更新日期：2009-11-13 00:00:00

abstract：:We have shown previously that activin A increases the number of immunoreactive follicle-stimulating hormone (FSH) cells. To further investigate the action of activin A, we examined its effects on anterior pituitary cells fractionated by centrifugal elutriation. Before activin A treatment, FSH cells were widely distrib...

journal_title：Molecular and cellular endocrinology

authors： Katayama T,Shiota K,Takahashi M

更新日期：1991-05-01 00:00:00

abstract：:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes,...

journal_title：Molecular and cellular endocrinology

authors： Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DA

更新日期：2013-07-05 00:00:00

abstract：:Protein tyrosine kinases (PTKs) are key enzymes implicated in signal transduction pathways regulated by growth factors (GFs). We have previously shown by immunohistochemistry that the level of phosphotyrosine (pY) proteins is increased in prostatic basal epithelial cells following estrogen treatment in castrated dogs....

journal_title：Molecular and cellular endocrinology

authors： Allard P,Atfi A,Landry F,Chapdelaine A,Chevalier S

更新日期：1997-01-03 00:00:00

abstract：:Type I pseudohypoaldosteronism (PHA1) is a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting and failure to thrive. Typical biochemical features include high levels of plasma aldosterone and renin, hyponatremia and hyperkalemia. Different mutations of the human mineralocorticoid re...

journal_title：Molecular and cellular endocrinology

authors： Sartorato P,Khaldi Y,Lapeyraque AL,Armanini D,Kuhnle U,Salomon R,Caprio M,Viengchareun S,Lombès M,Zennaro MC

更新日期：2004-03-31 00:00:00

abstract：:Peripheral benzodiazepine (BZ) binding sites (PBzS) were characterized on placental explant membranes. [3H]PK 11195, an isoquinoline carboxamide derivative, which is a ligand specific for PBzS, labeled these sites with an equilibrium dissociation constant of 2.1 nM; the maximal number of binding sites was 396 fmol/mg ...

journal_title：Molecular and cellular endocrinology

authors： Barnea ER,Fares F,Gavish M

更新日期：1989-07-01 00:00:00

abstract：:To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

journal_title：Molecular and cellular endocrinology

authors： Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

更新日期：2013-01-30 00:00:00

abstract：:In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α-provoked changes in the corpus luteum a short time-course (0.5-4 h) was performed on cows at midcycle. A microarray-determined transcriptome was...

journal_title：Molecular and cellular endocrinology

authors： Talbott H,Hou X,Qiu F,Zhang P,Guda C,Yu F,Cushman RA,Wood JR,Wang C,Cupp AS,Davis JS

更新日期：2017-09-05 00:00:00

abstract：:The study of the somatostatins (SS) signaling system in fish has provided important information about the structure, function, and evolution of SSs and their receptors. The SS signaling system elicits widespread biological actions via multiple hormone variants, numerous receptor subtypes, and a variety of signal trans...

journal_title：Molecular and cellular endocrinology

authors： Klein SE,Sheridan MA

更新日期：2008-05-14 00:00:00

abstract：:Basal and gonadotropin stimulated adenylate cyclase activity was assessed in testicular tissues obtained from men (20-80 years). A disparity was observed in the gonadotropin responsiveness of the human testicular adenylate cyclase system to hFSH and hCG stimulation. Of the tissues analyzed, 61% were FSH responsive and...

journal_title：Molecular and cellular endocrinology

authors： Berman MI,Anand-Srivastava MB,Sairam MR

更新日期：1985-08-01 00:00:00

abstract：:Insulin secretion from MIN6 cells configured as cell aggregates by culture on a gelatin substrate (pseudoislets) is enhanced compared to that of MIN6 cells grown as monolayers on tissue culture plastic, indicating the importance of beta-cell-to-beta-cell proximity for insulin release. In this study we have shown that ...

journal_title：Molecular and cellular endocrinology

authors： Hauge-Evans AC,Squires PE,Belin VD,Roderigo-Milne H,Ramracheya RD,Persaud SJ,Jones PM

更新日期：2002-06-14 00:00:00

abstract：:TGF beta1 has been detected by immunohistochemistry in the rat fetal testis. Therefore, we attempted to determine whether this factor can act as a local regulator of Leydig cell function during fetal development. An inhibitory effect of TGF beta1 on basal and luteinizing hormone (LH)-stimulated testosterone secretion ...

journal_title：Molecular and cellular endocrinology

authors： Gautier C,Levacher C,Saez JM,Habert R

更新日期：1997-07-04 00:00:00

abstract：:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

journal_title：Molecular and cellular endocrinology

authors： Li R,Cui J,Shen Y

更新日期：2014-05-25 00:00:00

abstract：:Differences in sialic acid content of the hormone have been considered the main determinant of FSH polymorphism. The aim of the present study was to investigate the effect of variations in the oligosaccharide structure of the intrapituitary human FSH (hFSH) glycosylation variants on their intrinsic biological activity...

journal_title：Molecular and cellular endocrinology

authors： Creus S,Chaia Z,Pellizzari EH,Cigorraga SB,Ulloa-Aguirre A,Campo S

更新日期：2001-03-28 00:00:00

abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

journal_title：Molecular and cellular endocrinology

authors： Kurosu H,Kuro-O M

更新日期：2009-02-05 00:00:00

abstract：:Proinsulin folding imperfections cause extensive beta-cell defects known in diabetes. Here, we investigated whether exenatide can alleviate such defects in proinsulin conversion, beta-cell survival, and insulin secretion, in the Ins2+/Akita beta-cells that have a spontaneous mutation (Cys 96 Tyr) in the insulin 2 gene...

journal_title：Molecular and cellular endocrinology

authors： Tang W,Yuan Q,Xu B,Osei K,Wang J

更新日期：2017-01-05 00:00:00

abstract：:The initiation of transcription is accomplished via interactions of many different proteins with common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors play a crucial role in the specificity of transcription initiation. A group of sequence-specific DNA-binding proteins, related to...

journal_title：Molecular and cellular endocrinology

authors： Bouwman P,Philipsen S

更新日期：2002-09-30 00:00:00

abstract：:The secretagogue effects of prolactin (PRL) and of various agents acting on cAMP levels, forskolin, cholera toxin and iloprost (a stable analogue of prostaglandin I2) have been assessed in lactating doe mammary gland fragments in vitro. Forskolin (10 microM), cholera toxin (1 microgram/ml) and iloprost (10 mM) stimula...

journal_title：Molecular and cellular endocrinology

authors： Ollivier-Bousquet M

更新日期：1989-08-01 00:00:00

abstract：:The mechanism by which hCG increases the rat testicular vascular permeability was studied by injecting the testes with hCG (0.1-100 ng) together with testicular interstitial fluid (150 mul) or with the fluid alone (control) and measuring the uptake of i.v. injected [125I]hCG and the interstitial fluid volume in the te...

journal_title：Molecular and cellular endocrinology

authors： Veijola M,Rajaniemi H

更新日期：1986-05-01 00:00:00

abstract：:Thyroid hormones participate in the regulation of growth, development and energy expenditure of vertebrates. Type I (D1) and type II 5'deiodinases catalyze the peripheral conversion of the thyroid prohormone thyroxine to the active form triiodothyronine (T3). D1 is expressed in organs like liver, thyroid, and lactatin...

journal_title：Molecular and cellular endocrinology

authors： García-Solís P,Aceves C

更新日期：2003-03-28 00:00:00

abstract：:The nuclear receptor corepressor (NCoR) interacts with the DNA-bound thyroid receptor (TR) homodimer through two of its three receptor-interacting domains (RIDs). One of these RIDs must be the most N-terminal, termed N3, which preferentially works with the next closest RID, N2. Interestingly, the spacing between the R...

journal_title：Molecular and cellular endocrinology

authors： Astapova I,Dordek MF,Hollenberg AN

更新日期：2009-08-13 00:00:00

abstract：:Total RNA from several adult (6-18-month-old) rabbit tissues was characterized using an oligonucleotide probe derived from the extracellular domain of the nucleotide sequence of the rabbit growth hormone receptor (GH-R) cDNA. Multiple GH-R mRNA species of approximately 4.6, approximately 3.3, 2.1 and approximately 1.4...

journal_title：Molecular and cellular endocrinology

authors： Ymer SI,Herington AC

更新日期：1992-01-01 00:00:00