Hypoxia regulation of expression and angiogenic effects of vasoactive intestinal peptide (VIP) and VIP receptors in LNCaP prostate cancer cells.

abstract：:Transforming growth factor beta (TGF beta) caused a dose-dependent increase in both basal and follicle-stimulating hormone (FSH)-stimulated inhibin production by rat granulosa cells in culture. The TGF beta dose-response curve in the absence of FSH was approximately parallel to that in the presence of either a minimal...

journal_title：Molecular and cellular endocrinology

authors： Zhang ZW,Findlay JK,Carson RS,Herington AC,Burger HG

更新日期：1988-08-01 00:00:00

abstract：:The effects of propylthiouracil (PTU) treatment on vasopressin, angiotensin II, glucagon and alpha 1-adrenergic receptors in both developing and adult rats were studied in liver membrane preparations by measuring the binding of the following ligands: [3H][8-lysine]vasopressin, [3H]Sar-angiotensin II, [125I]glucagon an...

journal_title：Molecular and cellular endocrinology

authors： Ali M,Cantau B,Chicot D,Clos J

更新日期：1987-05-01 00:00:00

abstract：:Mammalian α4 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase. This study showed induction of the EDD protein by progesterone, 17β-estradiol and prolactin in breast cancer cells....

journal_title：Molecular and cellular endocrinology

authors： McDonald WJ,Thomas LN,Koirala S,Too CKL

更新日期：2014-01-25 00:00:00

abstract：:Tyrosine kinase activation in mediating the mitogenic action of prolactin (PRL) has been evaluated. Use was made of genistein, a tyrosine kinase antagonist, and cultured rat Nb2 lymphoma cells, i.e. the lactogen-dependent Nb2-11 line and a lactogen-independent subline, Nb2-SFJCD1. Genistein was found to be a potent gr...

journal_title：Molecular and cellular endocrinology

authors： Buckley AR,Buckley DJ,Gout PW,Liang H,Rao YP,Blake MJ

更新日期：1993-12-01 00:00:00

abstract：:The molecular cloning and nucleotide sequencing of the gonadotropin-releasing hormone (GnRH) receptor represented an enhanced step in the experimental effort to understand this key molecule in the reproductive process at a cell and molecular level. A subsequent step in this broad effort is heterologous expression of t...

journal_title：Molecular and cellular endocrinology

authors： Neill JD,Sellers JC,Musgrove LC,Duck LW

更新日期：1997-03-28 00:00:00

abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

journal_title：Molecular and cellular endocrinology

authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

更新日期：2018-02-05 00:00:00

abstract：:Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is...

journal_title：Molecular and cellular endocrinology

authors： Das SK,Balasubramanian P,Weerasekara YK

更新日期：2017-11-05 00:00:00

abstract：:Extracts from the plant Pygeum africanum are widely used in the therapy of benign prostate hyperplasia (BPH) and in combinational therapy for prostate cancer, the second leading cause of cancer death and the mostly diagnosed form of cancer in men. The androgen receptor (AR) plays a crucial role in the development of t...

journal_title：Molecular and cellular endocrinology

authors： Roell D,Baniahmad A

更新日期：2011-01-30 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroidal enzyme which, in breast cancer cells, mainly synthesizes 17-beta-estradiol (E2), an estrogenic hormone that stimulates breast cancer cell growth. We previously showed that the enzyme increased breast cancer cell proliferation via a dual effect on E2 ...

journal_title：Molecular and cellular endocrinology

authors： Aka JA,Calvo EL,Lin SX

更新日期：2017-01-05 00:00:00

abstract：:The recent cloning of several cDNAs encoding prostaglandin (PG) receptors has paved the way for a more detailed investigation of the postulated regulatory role of prostaglandins in corpus luteum function. We have utilized the reverse transcription-polymerase chain reaction (RT-PCR) to isolate a mRNA encoding the ovari...

journal_title：Molecular and cellular endocrinology

authors： Olofsson JI,Leung CH,Bjurulf E,Ohno T,Selstam G,Peng C,Leung PC

更新日期：1996-10-14 00:00:00

abstract：:We have shown that somatostatin agonist peptide CH275, selective to somatostatin receptor (sst) subtypes 1,4, was more effective in preventing intimal hyperplasia than the sst2,3,5-selective octreotide, raising the question what are the separate roles of the sst1- and 4-subtypes. Here, we dissect this observation furt...

journal_title：Molecular and cellular endocrinology

authors： Tigerstedt NM,Aavik E,Aavik S,Savolainen-Peltonen H,Hayry P

更新日期：2007-12-15 00:00:00

abstract：:In vitro RNA synthesis has been analyzed using autoradiographic and electrophoretic methods in isolated 1-2 mm segments of rat seminiferous tubules. The cellular composition of each segment was accurately identified using microscopic analysis of the transillumination pattern of the freshly isolated, unstained, seminif...

journal_title：Molecular and cellular endocrinology

authors： Söderström KO,Parvinen M

更新日期：1976-08-01 00:00:00

abstract：:Many genes that are required for fertility have been identified in model organisms (). Mutations in these genes cause infertility due to defects in development of the germ cell lineage, but the organism is otherwise healthy. Although human reproduction is undoubtedly as complex as that of other organisms, very few fer...

journal_title：Molecular and cellular endocrinology

authors： Fox MS,Reijo Pera RA

更新日期：2001-11-26 00:00:00

abstract：:Studies on the age-related decline of growth hormone (GH) release have ignored that the population of GH-producing cells (somatotropes) is heterogeneous. In aging male rats, centrifugation of dispersed pituitary cells in a density gradient yields two somatotrope subpopulations, i.e. low- (LD) and high-density (HD) cel...

journal_title：Molecular and cellular endocrinology

authors： Dobado-Berrios PM,Ruiz-Navarro A,Lopez-Pedrera R,Gonzalez de Aguilar JL,Torronteras R,Hidalgo-Diaz C,Gracia-Navarro F

更新日期：1996-10-30 00:00:00

abstract：:Over 20 mutations affecting the neurophysin moiety of the vasopressin prohormone, have been identified in families suffering from familial neurohypophysial diabetes insipidus (FNDI). Only one of these, NP87E-->stop, is located outside the central conserved domain implicated in sorting of the vasopressin prohormone. To...

journal_title：Molecular and cellular endocrinology

authors： Nijenhuis M,Zalm R,Burbach JP

更新日期：2000-09-25 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ isoform that contains two nuclear recep...

journal_title：Molecular and cellular endocrinology

authors： Snyder CA,Goodson ML,Schroeder AC,Privalsky ML

更新日期：2015-09-15 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increas...

journal_title：Molecular and cellular endocrinology

authors： Fujimori C,Ogiwara K,Hagiwara A,Takahashi T

更新日期：2012-10-15 00:00:00

abstract：:Glucocorticoids (GCs) exert profound effects on bone and are essential for human osteoblast differentiation. However, GCs are still interpreted as negative regulators of bone formation, mainly caused by the detrimental effects on bone after clinical use of GCs. In this paper we emphasize the importance of GCs for prop...

journal_title：Molecular and cellular endocrinology

authors： Eijken M,Koedam M,van Driel M,Buurman CJ,Pols HA,van Leeuwen JP

更新日期：2006-03-27 00:00:00

abstract：:During rapid development of the fetus, levels of high density lipoprotein (HDL) are elevated in pregnant women. The receptor for HDL, scavenger receptor class B type I (SR-BI), mediates selective cholesteryl ester uptake and is highly expressed in the human placenta. Because of the rapid growth of uterus during early ...

journal_title：Molecular and cellular endocrinology

authors： Kim JG,Vallet JL,Nonneman D,Christenson RK

更新日期：2004-07-30 00:00:00

abstract：:The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP contribution to the decidualization program and to immunoregulation throughout the human embryo impl...

journal_title：Molecular and cellular endocrinology

authors： Grasso E,Gori S,Paparini D,Soczewski E,Fernández L,Gallino L,Salamone G,Martinez G,Irigoyen M,Ruhlmann C,Pérez Leirós C,Ramhorst R

更新日期：2018-01-15 00:00:00

abstract：:The aim of this study was to investigate whether co-culture of human islets with adipose-derived stem cells (ASCs) can improve islet quality and to evaluate which factors play a role in the protective effect of ASCs against islet dysfunction. Islets and ASCs were cultured in three experimental groups for 24 h, 48 h, a...

journal_title：Molecular and cellular endocrinology

authors： de Souza BM,Rodrigues M,de Oliveira FS,da Silva LPA,Bouças AP,Portinho CP,Dos Santos BP,Camassola M,Rocha D,Lysakowski S,Martini J,Leitão CB,Nardi NB,Bauer AC,Crispim D

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND/PURPOSE:It remains unclear what role curcumin plays in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis, since some researchers found that curcumin has the ability to inhibit osteoclastogenesis. While others have considered it as an autophagy activator. This study aimed to determine th...

journal_title：Molecular and cellular endocrinology

authors： Ke D,Wang Y,Yu Y,Wang Y,Zheng W,Fu X,Han J,Zhang G,Xu J

更新日期：2020-01-15 00:00:00

abstract：:Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to pigmentation to the regulation of feeding. One approach to unraveling the complexi...

journal_title：Molecular and cellular endocrinology

authors： Costa JL,Forbes S,Brennan MB,Hochgeschwender U

更新日期：2011-04-10 00:00:00

abstract：:The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted. 131Iodide (131I) is an important treatment for DTC and has the potential to reduce the risk ...

journal_title：Molecular and cellular endocrinology

authors： Zhao Y,Zhong L,Yi H

更新日期：2019-01-05 00:00:00

abstract：:The human corticotropin-releasing factor receptor type 1 (hCRF-R1) functional transcript is mainly expressed in the anterior pituitary corticotrophs, a tissue usually not available for clinical investigation. Splice variants translated into defective isoforms of the receptor have been described in few peripheral tissu...

journal_title：Molecular and cellular endocrinology

authors： Ben Simon E,Besancon R,Benetollo C,Nicolino M,Saez JM,Li JY

更新日期：2003-01-31 00:00:00

abstract：:Corticotropin-releasing factor (CRF) receptor type 1 (CRF(1) receptor) mRNA levels are down-regulated by CRF via the cyclic AMP-protein kinase A (PKA) pathway. In this study, we focused on the involvement of both the mitogen-activated protein (MAP) kinase pathway and PKA in this regulation. Real-time PCR (RT-PCR) reve...

journal_title：Molecular and cellular endocrinology

authors： Moriyama T,Kageyama K,Kasagi Y,Iwasaki Y,Nigawara T,Sakihara S,Suda T

更新日期：2005-11-24 00:00:00

abstract：:Auto-regulation of the three goldfish estrogen receptor (ER) subtypes was examined simultaneously in multiple tissues, in relation to mRNA levels of liver vitellogenin (VTG) and brain transcripts. Male goldfish were implanted with a silastic implant containing either no steroid or 17beta-estradiol (E2) (100 microg/g b...

journal_title：Molecular and cellular endocrinology

authors： Marlatt VL,Martyniuk CJ,Zhang D,Xiong H,Watt J,Xia X,Moon T,Trudeau VL

更新日期：2008-02-13 00:00:00

abstract：:Menin is a protein product of a tumor supressor gene MEN1, mutations of which are responsible for multiple endocrine neoplasia type 1, an autosomal dominant familial cancer syndrome. We determined the nucleotide sequence of the Drosophila menin cDNA using RT-PCR and RACE, and confirmed it by direct sequencing of genom...

journal_title：Molecular and cellular endocrinology

authors： Maruyama K,Tsukada T,Honda M,Nara-Ashizawa N,Noguchi K,Cheng J,Ohkura N,Sasaki K,Yamaguchi K

更新日期：2000-10-25 00:00:00