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A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer.

Abstract：

:The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted. 131Iodide (131I) is an important treatment for DTC and has the potential to reduce the risk of recurrence. 131I is also an effective treatment for distant metastases of thyroid carcinoma. However, iodide metabolism dysfunction in metastatic foci causes patients to lose the opportunity of 131I treatment. This article reviews the related mechanisms of iodide metabolism dysfunction in DTC cells and summarizes the clinical transformation progression.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Zhao Y,Zhong L,Yi H

doi

10.1016/j.mce.2018.09.002

subject

Has Abstract

pub_date

2019-01-05 00:00:00

pages

71-77

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(18)30264-8

journal_volume

479

pub_type

杂志文章,评审

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