当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia.

Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia.

Abstract：

:Glucocorticoids (GCs) are used in combination therapy for treating acute lymphoblastic leukemia (ALL). In T-cell (CEM-C7) and pre-B-cell (697) ALL cell lines, dexamethasone (Dex) treatment causes an auto-upregulation of glucocorticoid receptor (GR) mRNA transcripts and protein. We hypothesized that there is a threshold level of GR transcripts/protein needed for cells to respond to the apoptosis-inducing effects of hormone. GR knock down using a doxycycline-controllable shRNAmir indicated that the apoptotic response changes from sensitive to resistant with changing GR levels. Titration of the 697 cell GR to equal that of the CEM-C7 T-cell ALL line caused a shift in sensitivity to that seen in CEM-C7 cells. While the same level of GR is required to trigger apoptosis in both T-cell and pre-B-cell ALL lineages, similarities and differences were observed for the regulation of target genes in these lineages. These preliminary gene regulation patterns may lead to the development of a molecular signature for GC-sensitive and GC-resistant leukemia cells.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Schwartz JR,Sarvaiya PJ,Vedeckis WV

doi

10.1016/j.mce.2010.02.014

subject

Has Abstract

pub_date

2010-05-14 00:00:00

pages

76-86

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(10)00090-0

journal_volume

320

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Nuclear Receptors in atherosclerosis: a superfamily with many 'Goodfellas'.

    abstract：:Nuclear Receptors form a superfamily of 48 transcription factors that exhibit a plethora of functions in steroid hormone signaling, regulation of metabolism, circadian rhythm and cellular differentiation. In this review, we describe our current knowledge on the role of Nuclear Receptors in atherosclerosis, which is a ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2012.05.014

    authors： Kurakula K,Hamers AA,de Waard V,de Vries CJ

    更新日期：2013-04-10 00:00:00

  • Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site.

    abstract：:Activation of the angiotensin II type 1 receptor (AT1R) is closely involved in the pathogenesis of cardiovascular disease. The human AT1R (hAT1R) mRNA splice variants have long 5'-untranslated regions (5'-UTRs) ranging from 272 to 414 bp that have the potential to form stable secondary structures. In this study, we sh...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.09.017

    authors： Martin MM,Garcia JA,McFarland JD,Duffy AA,Gregson JP,Elton TS

    更新日期：2003-12-30 00:00:00

  • Ets-1 activates parathyroid hormone-related protein gene expression in tumorigenic breast epithelial cells.

    abstract：:Parathyroid hormone-related protein (PTHrP) is produced by many tumors not associated with humoral hypercalcemia, including breast cancers. In this study, we used three human immortalized mammary epithelial cell lines that differ in tumorigenicity and PTHrP expression. Using RT-PCR we investigated 5' and 3' alternativ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00298-8

    authors： Cataisson C,Gordon J,Roussière M,Abdalkhani A,Lindemann R,Dittmer J,Foley J,Bouizar Z

    更新日期：2003-06-30 00:00:00

  • Function and expression of somatostatin receptors of the endocrine pancreas.

    abstract：:Somatostatin (SST) regulates multiple biological processes via five genetically distinct, G-protein coupled receptors. Clinical interest in therapy for neuroendocrine and metabolic disorders has resulted in the development of new tools for exploring the function of somatostatin receptors (SSTRs). The development of hi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.02.007

    authors： Strowski MZ,Blake AD

    更新日期：2008-05-14 00:00:00

  • Inactivating mutations of the mineralocorticoid receptor in Type I pseudohypoaldosteronism.

    abstract：:Type I pseudohypoaldosteronism (PHA1) is a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting and failure to thrive. Typical biochemical features include high levels of plasma aldosterone and renin, hyponatremia and hyperkalemia. Different mutations of the human mineralocorticoid re...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2003.10.017

    authors： Sartorato P,Khaldi Y,Lapeyraque AL,Armanini D,Kuhnle U,Salomon R,Caprio M,Viengchareun S,Lombès M,Zennaro MC

    更新日期：2004-03-31 00:00:00

  • Marsupial models for understanding evolution of thyroid hormone distributor proteins.

    abstract：:Marsupials are a group of mammals that are under-exploited, in particular in developmental and evolutionary studies of biological systems. In this review, the roles that marsupials have played in elucidating the evolution of thyroid hormone distribution systems are summarised. Marsupials are born at very early develop...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.04.002

    authors： Richardson SJ

    更新日期：2008-10-10 00:00:00

  • Hormonal regulation of thyroidal protein phosphokinase activities. II. Differential sensitivity of type I and type II cAMP-dependent enzymes to the treatment of rats with thyroxine.

    abstract：:Two cAMP-dependent protein kinase activities can be separated from rat thyroid cytosol. Their elution properties during the gel chromatography, as well as their sedimentation coefficients after sucrose-gradient ultracentrifugation and their capacity to dissociate in the presence of histones, suggest they are like the ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(79)90102-3

    authors： Delbauffe D,Ohayon R,Pavlovic-Hournac M

    更新日期：1979-05-01 00:00:00

  • Carboxypeptidase H in bovine pituitary gland: soluble forms are not processed at the C-terminus.

    abstract：:Carboxypeptidase H (CP-H) has been characterized in anterior and posterior lobes of bovine pituitary with regard to subcellular distribution, enzymatic properties, nature of membrane association, number of forms and C-terminal processing. Anterior lobe contained both soluble and membrane forms of CP-H with similar enz...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90147-x

    authors： Parkinson D

    更新日期：1992-08-01 00:00:00

  • Evidence for the involvement of essential sulphydryl group in rat hepatic lactogenic receptor but not in somatogenic receptor.

    abstract：:Incorporation of p-chloromercuribenzene sulphonate (PCMBS) (1mM) in the assay medium for rat hepatic lactogenic receptor produced complete inhibition of binding of [125I]oPRL to the membrane. However, the presence of the thiol-reactive agent produced no effect on the binding of [125I]bGH to rat hepatic somatogenic rec...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90145-x

    authors： Tsim KW,Cheng CH

    更新日期：1984-11-01 00:00:00

  • Melatonin: the watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis.

    abstract：:Human placenta produces melatonin and expresses its receptors. We propose that melatonin, an antioxidant, protects the human placenta against hypoxia/reoxygenation (H/R)-induced damage. Primary term villous cytotrophoblasts were cultured under normoxia (8% O2) with or without 1mM melatonin for 72h to induce differenti...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.07.010

    authors： Lanoix D,Lacasse AA,Reiter RJ,Vaillancourt C

    更新日期：2013-12-05 00:00:00

  • Neuropeptide Y impairs insulin-stimulated translocation of glucose transporter 4 in 3T3-L1 adipocytes through the Y1 receptor.

    abstract：:Neuropeptide Y (NPY) is expressed in adipose tissue and is involved in adipocyte metabolism. Although NPY impacts on glucose utilization in vivo, the underlying cellular mechanism is yet to be fully elucidated. In this study we investigated the effect of NPY on the insulin-stimulated translocation of glucose transport...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.07.028

    authors： Gericke MT,Schröder T,Kosacka J,Nowicki M,Klöting N,Spanel-Borowski K

    更新日期：2012-01-02 00:00:00

  • Dibutyryl cyclic AMP-induced phosphorylation of specific proteins in adenohypophysial cells.

    abstract：:The objective of this work was to identify the natural substrates of cyclic AMP-dependent protein kinase in pituitary cells. Studies were performed using 2 systems: intact pituitary cells stimulated with dibutyryl cyclic AMP (DBC) after preincubation with [gamma-32P]. Phosphorylation of proteins was analyzed by two-di...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(81)90118-0

    authors： Brattin WJ Jr,Portanova R

    更新日期：1981-07-01 00:00:00

  • Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.

    abstract：:The screening of an oligo(dT)-primed prostate cDNA library with a human glandular kallikrein-1 (hGK-1) genomic DNA fragment resulted in the isolation of two different hGK-1 cDNAs. A 1.2 kb cDNA (pGK-1) contains an open reading frame of 510 bp, encoding the major part of the previously predicted hGK-1 protein (Schedlic...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(91)90272-t

    authors： Riegman PH,Vlietstra RJ,van der Korput HA,Romijn JC,Trapman J

    更新日期：1991-04-01 00:00:00

  • Vitamin D-dependency rickets type II: truncated vitamin D receptor in three kindreds.

    abstract：:Fibroblasts from three patients with vitamin D-dependency rickets type II were used to study mutations in the 1,25-dihydroxyvitamin D3 receptor responsible for this hereditary disease. Normal human fibroblasts contain 43 +/- 13 fmol receptor/mg protein as determined by immunoradiometric assay and 22 +/- 3 fmol/mg by l...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(93)90152-a

    authors： Wiese RJ,Goto H,Prahl JM,Marx SJ,Thomas M,al-Aqeel A,DeLuca HF

    更新日期：1993-01-01 00:00:00

  • Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization.

    abstract：:Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role d...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.08.011

    authors： Zhang XH,Liang X,Wang TS,Liang XH,Zuo RJ,Deng WB,Zhang ZR,Qin FN,Zhao ZA,Yang ZM

    更新日期：2013-12-05 00:00:00

  • Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs.

    abstract：:The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins and an important drug target due to their role in many (patho)physiological processes. Besides small molecules, GPCRs can be targeted by biologicals including antibodies and antibody fragments. This review describes the use of ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2019.01.021

    authors： De Groof TWM,Bobkov V,Heukers R,Smit MJ

    更新日期：2019-03-15 00:00:00

  • Cyclic nucleotide phosphodiesterase in developing rat testis. Identification of somatic and germ-cell forms.

    abstract：:Several forms of phosphodiesterase are present in the male gonad, and their relative concentrations vary during testicular development. On the basis of kinetic analysis and chromatography on DEAE cellulose, 3 forms were separated: (a) a high-affinity cGMP phosphodiesterase, regulated by Ca2+ and calmodulin, similar to...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90039-9

    authors： Geremia R,Rossi P,Pezzotti R,Conti M

    更新日期：1982-09-01 00:00:00

  • The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma.

    abstract：:The objective of this study was to analyze the correlation between matrix metalloproteinases (MMPs) and angiogenic genes and survival in advanced-stage ovarian carcinomas. Primary and metastatic ovarian carcinomas from patients diagnosed with FIGO stage III-IV disease and followed up to 20 years were studied using mRN...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00709-2

    authors： Davidson B,Goldberg I,Gotlieb WH,Kopolovic J,Ben-Baruch G,Nesland JM,Reich R

    更新日期：2002-02-22 00:00:00

  • Retinoic acid stimulates glucose transporter expression in L6 muscle cells.

    abstract：:Factors that regulate the tissue specific and developmental expression of the GLUT4 gene, whose transcribed protein is primarily responsible for mediating insulin stimulated glucose transport, are poorly defined. In this study we examined the effects of retinoic acid, a circulating factor that can promote cellular dif...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03473-k

    authors： Sleeman MW,Zhou H,Rogers S,Ng KW,Best JD

    更新日期：1995-02-27 00:00:00

  • The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.

    abstract：:The luteinizing hormone receptor (LHR), one of the three glycoprotein hormone receptors, is necessary for critical reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation, and male sex differentiation. Moreover, it has been postulated to contribute to certain neoplasms, particularly ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.04.025

    authors： Puett D,Angelova K,da Costa MR,Warrenfeltz SW,Fanelli F

    更新日期：2010-11-25 00:00:00

  • The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells.

    abstract：:Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid retention; however, the effect of pioglitazone on aldost...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.07.007

    authors： Pan ZQ,Xie D,Choudhary V,Seremwe M,Tsai YY,Olala L,Chen X,Bollag WB

    更新日期：2014-08-25 00:00:00

  • Transcript profiles and triiodothyronine regulation of sex steroid- and thyroid hormone-related genes in the gonad-mesonephros complex of Silurana tropicalis.

    abstract：:In amphibians, the main role of thyroid hormones (THs) is to regulate metamorphosis; however, there is evidence that THs also affect gonadal sexual differentiation. In this study, Silurana (Xenopus) tropicalis tadpoles were exposed to triiodothyronine (T3; 0, 0.5, 5 and 50 nM), the bioactive form of THs for 48h. Real-...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.09.004

    authors： Duarte-Guterman P,Trudeau VL

    更新日期：2011-01-01 00:00:00

  • The influence of dexamethasone on serum thyrotrophin and thyrotrophin synthesis in the rat.

    abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90064-6

    authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

    更新日期：1989-06-01 00:00:00

  • Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix.

    abstract：:If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2006.10.014

    authors： Delvenne P,Herman L,Kholod N,Caberg JH,Herfs M,Boniver J,Jacobs N,Hubert P

    更新日期：2007-01-29 00:00:00

  • H1 histone synthesis and phosphorylation in mouse mammary gland in vitro.

    abstract：:The synthesis and phosphorylation of H1 histones were studied in organ cultures of midpregnant mouse mammary glands exposed to various combinations of insulin, cortisol and prolactin over a 48-h period. The synthesis of specific H1 histone subtypes was changed only when all three hormones were present, and the effect ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90137-7

    authors： Hohmann P,Hughes C

    更新日期：1987-11-01 00:00:00

  • Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

    abstract：:The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2015.02.005

    authors： Spiga F,Lightman SL

    更新日期：2015-06-15 00:00:00

  • Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary gland.

    abstract：:Explants from the mammary gland of 6 lactating cows were cultured in M-199 medium containing insulin (1.0 micrograms/ml) and hydrocortisone (0.5 micrograms/ml) and supplemented with bPRL (0.2-1.0 micrograms/ml) or oGH (0.1, 0.5 and 2.5 micrograms/ml) or bGH or hGH (0.2 and 1.0 micrograms/ml). It was found that neither...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(83)90165-x

    authors： Gertler A,Cohen N,Maoz A

    更新日期：1983-12-01 00:00:00

  • Decreased proliferation and cell cycle arrest in neoplastic rat pituitary cells is associated with transforming growth factor-beta1-induced expression of p15/INK4B.

    abstract：:Transforming growth factor beta (TGF-beta) is a member of a family of cytokines that regulate differentiation and proliferation in a wide variety of tissues including the pituitary gland. In both the normal pituitary and tumorous cell lines TGF-beta1 has anti-proliferative activity, however the intracellular mechanism...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00477-4

    authors： Frost SJ,Simpson DJ,Farrell WE

    更新日期：2001-05-15 00:00:00

  • Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.

    abstract：:The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH)2D3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH)2D3 exer...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2017.05.001

    authors： Reichrath J,Saternus R,Vogt T

    更新日期：2017-09-15 00:00:00

  • A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway.

    abstract：:Adipose tissue-derived adipokines play important roles as regulators of skeletal growth and development. CTRP1, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. It is expressed at high levels in adipose tissue and has recently emerged as a novel adipo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2013.01.002

    authors： Akiyama H,Otani M,Sato S,Toyosawa S,Furukawa S,Wakisaka S,Maeda T

    更新日期：2013-04-30 00:00:00