当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary gland.

Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary gland.

Abstract：

:Explants from the mammary gland of 6 lactating cows were cultured in M-199 medium containing insulin (1.0 micrograms/ml) and hydrocortisone (0.5 micrograms/ml) and supplemented with bPRL (0.2-1.0 micrograms/ml) or oGH (0.1, 0.5 and 2.5 micrograms/ml) or bGH or hGH (0.2 and 1.0 micrograms/ml). It was found that neither oGH nor bGH significantly increased (P less than 0.05) the casein and fat synthesis and alpha-lactalbumin secretion above the control level. A significant and almost equal increase was, however, observed in the presence of bPRL and hGH, but was not influenced by the simultaneous addition of oGH to bPRL-containing medium (both at 0.5 micrograms/ml). Various hormonal treatments did not affect casein secretion and glucose uptake. High correlations (r = 0.89-0.97) were found between the mean values for casein and fat synthesis and alpha-lactalbumin secretion. Our results suggest that (a) the in vivo galactopoietic activity of bGH does not result from a direct effect of synthetic capacities on the mammary gland, and (b) hGH is a potent lactogen in the organ culture of bovine lactating mammary tissue.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Gertler A,Cohen N,Maoz A

doi

10.1016/0303-7207(83)90165-x

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

169-82

issue

2-3

eissn

0303-7207

issn

1872-8057

journal_volume

33

pub_type

杂志文章

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