Abstract：
:Inhibin A and B are dimeric proteins capable of suppressing FSH both in vitro and in vivo. The principal form in the male is inhibin B which is produced in the testis and circulates to inhibit pituitary FSH secretion. Activin A, B and AB are dimeric proteins that share the same beta subunits with the inhibins but, in contrast, stimulate FSH secretion. Although activin A circulates, castration does not lead to a decrease in serum concentrations, indicating that the testis is not the major source of activin A. In the circulation, the activins are bound to a structurally unrelated binding protein, follistatin, that neutralizes the biological actions of these proteins. The subunits of the inhibins/activins as well as follistatin are also produced locally within the pituitary and their levels can be modulated by testosterone and gonadotrophin releasing hormone as well as by autocrine mechanisms. Consequently, the output of FSH is dependent of the balance between local processes and the circulating feedback exerted by testosterone and inhibin. There is increasing data to support the local gonadal production of not only inhibin but also activin and follistatin by both germ cells and somatic cells such as the Sertoli cells. Evidence is accumulating to support the concept that these proteins exert local regulatory mechanisms in the testis.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
de Kretser DM,Meinhardt A,Meehan T,Phillips DJ,O'Bryan MK,Loveland KAdoi
10.1016/s0303-7207(99)00222-1keywords:
subject
Has Abstractpub_date
2000-03-30 00:00:00pages
43-6issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(99)00222-1journal_volume
161pub_type
杂志文章,评审abstract：:Inhibin production by cultured granulosa cells from immature diethylstilbestrol (DES)-primed rats was studied in relation to estradiol and progesterone production. The inhibin content in culture media was assayed with a specific radioimmunoassay (RIA) using an antibody to porcine 32 kDa inhibin that recognizes rat inh...
journal_title：Molecular and cellular endocrinology
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更新日期：2013-08-25 00:00:00
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更新日期：2003-11-28 00:00:00
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更新日期：1988-06-01 00:00:00
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更新日期：1994-05-01 00:00:00
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更新日期：2021-02-05 00:00:00
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journal_title：Molecular and cellular endocrinology
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更新日期：2002-02-22 00:00:00
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pub_type： 杂志文章
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更新日期：1977-10-01 00:00:00
