Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:Recent developments in the regulation of testicular Leydig-cell function support the following conclusions. (1) Enzymic activities involved in steroid production in the testis are mainly localized in Leydig cells. The aromatase enzyme complex for oestrogen production appears to be localized in Leydig cells as well as ...

journal_title：Molecular and cellular endocrinology

authors： Rommerts FF,Brinkman AO

更新日期：1981-01-01 00:00:00

abstract：:In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between sever...

journal_title：Molecular and cellular endocrinology

authors： Dacheux JL,Belleannée C,Jones R,Labas V,Belghazi M,Guyonnet B,Druart X,Gatti JL,Dacheux F

更新日期：2009-07-10 00:00:00

abstract：:Cardiac fibrosis evolves from the cardiac hypertrophic state. In this respect, estrogen and estrogen receptor beta (ERβ) inhibit the effects of cardiac hypertrophic peptides that also stimulate fibrosis. Here we determine details of the anti-fibrotic functions of ERβ. In acutely isolated rat cardiac fibroblasts. E2 or...

journal_title：Molecular and cellular endocrinology

authors： Pedram A,Razandi M,Narayanan R,Levin ER

更新日期：2016-10-15 00:00:00

abstract：:Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation emb...

journal_title：Molecular and cellular endocrinology

authors： You JL,Wang W,Tang MY,Ye YH,Liu AX,Zhu YM

更新日期：2018-07-15 00:00:00

abstract：:Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid-binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-deple...

journal_title：Molecular and cellular endocrinology

authors： Krautbauer S,Haberl EM,Eisinger K,Pohl R,Rein-Fischboeck L,Rentero C,Alvarez-Guaita A,Enrich C,Grewal T,Buechler C,Neumeier M

更新日期：2017-01-05 00:00:00

abstract：:Increased production of inflammatory cytokines is suggested to be of importance for initiation and progression of insulin resistance. Chronic treatment with the AMP analogue 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR) has been shown to improve insulin sensitivity and prevent the development of diabe...

journal_title：Molecular and cellular endocrinology

authors： Lihn AS,Pedersen SB,Lund S,Richelsen B

更新日期：2008-09-24 00:00:00

abstract：:Calcium homeostasis refers to the regulation of calcium ion concentration in the body. This concentration is tightly controlled by a stabilizing system consisting of calcium channels and calcium buffering proteins. Calcium homeostasis is crucial for cell survival. Various forms of cell death (e.g., necrosis and apopto...

journal_title：Molecular and cellular endocrinology

authors： Ahn C,An BS,Jeung EB

更新日期：2015-09-05 00:00:00

abstract：:The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, tran...

journal_title：Molecular and cellular endocrinology

authors： Chang H,Lau AL,Matzuk MM

更新日期：2001-06-30 00:00:00

abstract：:We studied the ontogeny of GH receptor mRNA levels and the effect of exogenous estradiol administration on GH receptor mRNA levels in rabbit liver. A solution hybridization-RNase protection assay revealed a predominant 370-base long protected band corresponding to the mRNA encoding the transmembrane GH receptor, and a...

journal_title：Molecular and cellular endocrinology

authors： Domené HM,Marín G,Sztein J,Yu YM,Baron J,Cassorla FG

更新日期：1994-07-01 00:00:00

abstract：:Pituitary adenomas (PAs) hypersecrete hormones or cause mass effect symptoms, with 10%-35% patients showing resistance to standard therapies. Targeting epidermal growth factor receptor (EGFR) has significantly improved the clinical outcome in many cancers. In this study, immunochemistry results showed that EGFR associ...

journal_title：Molecular and cellular endocrinology

authors： Wei D,Yu Z,Cheng Y,Jiawei H,Jian G,Hua G,Guilan D

更新日期：2021-01-15 00:00:00

abstract：:The effects of calcitonin (CT) on the cellular transport and accumulation of Ca were studied in bone cells grown in primary culture. The following sequence of events was detected: (1) After 1--2 h of incubation with CT the initial rate of Ca influx into bone cells transiently increased. A longer incubation with CT (3-...

journal_title：Molecular and cellular endocrinology

authors： Eilam Y,Szydel N,Harell A

更新日期：1980-06-01 00:00:00

abstract：:Within the seminiferous tubules, the Sertoli cells create an impermeable blood-testis barrier and an unique intratubular microenvironment that fosters the development of spermatozoa. The functional differentiation of spermatozoa therefore requires vectorial secretion by Sertoli cells of substances that cannot cross th...

journal_title：Molecular and cellular endocrinology

authors： Spaliviero JA,Handelsman DJ

更新日期：1991-10-01 00:00:00

abstract：:We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deac...

journal_title：Molecular and cellular endocrinology

authors： Tao RH,Kawate H,Wu Y,Ohnaka K,Ishizuka M,Inoue A,Hagiwara H,Takayanagi R

更新日期：2006-03-09 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is expressed after birth in the ovary in the granulosa cells of healthy, small growing follicles. We have shown that AMH affects two important regulatory steps during folliculogenesis. At initial recruitment, AMH inhibits recruitment of primordial follicles into the growing pool, while at ...

journal_title：Molecular and cellular endocrinology

authors： Gruijters MJ,Visser JA,Durlinger AL,Themmen AP

更新日期：2003-12-15 00:00:00

abstract：:We have identified a specific LHR mRNA binding protein that selectively binds to the polypyrimidine-rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. This process has been shown to be one of the mechanisms that is responsible for the loss of the steady-state levels of LHR mR...

journal_title：Molecular and cellular endocrinology

authors： Menon KM,Menon B,Wang L,Gulappa T,Harada M

更新日期：2010-11-25 00:00:00

abstract：:Some environmental contaminants and pharmaceuticals increase the incidence of uterine tumors in toxicological studies with rats. These tumors can result from a hormonal imbalance due to rat-specific disrupted pituitary prolactin regulation, and are therefore of questionable relevance for humans. In this study we compa...

journal_title：Molecular and cellular endocrinology

authors： van den Brand AD,Rubinstein E,van den Berg M,van Duursen MBM

更新日期：2019-10-01 00:00:00

abstract：:In order to study the distribution of LH (HCG) receptors on luteal cells ferritin was coupled to ovine LH with glutaraldehyde and purified by gel chromatography. The conjugate (FELH) competed with 125I-hCG for binding to isolated luteal membranes and stimulated a dose-dependent release of progesterone (P) from isolate...

journal_title：Molecular and cellular endocrinology

authors： Luborsky JL,Behrman HR

更新日期：1979-08-01 00:00:00

abstract：:The orphan nuclear receptor steroidogenic factor 1 (SF-1) was identified originally as a key regulator of the tissue-specific expression of the cytochrome P450 steroid hydroxylases. Hints at considerably broader roles for SF-1 came from analyses of its expression pattern in mouse embryos. As anticipated, SF-1 was expr...

journal_title：Molecular and cellular endocrinology

authors： Hanley NA,Ikeda Y,Luo X,Parker KL

更新日期：2000-05-25 00:00:00

abstract：:The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-r...

journal_title：Molecular and cellular endocrinology

authors： Oldridge EE,Pellacani D,Collins AT,Maitland NJ

更新日期：2012-09-05 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is a potent mitogen for several cell types. In addition, PDGF has vasoconstrictive action and shares some signal transduction mechanisms with angiotensin II (AII). In the present study, we have examined the effects of PDGF on basal and AII-induced aldosterone synthesis in freshly ...

journal_title：Molecular and cellular endocrinology

authors： Natarajan R,Nadler J

更新日期：1992-01-01 00:00:00

abstract：:Emerging evidence shows a beneficial effect of estrogens for Parkinson's disease, yet the exact potency of these compounds implicated remain obscured. In this study, we investigated the neuroprotective effect of 17beta-estradiol and estrone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal t...

journal_title：Molecular and cellular endocrinology

authors： Ookubo M,Yokoyama H,Takagi S,Kato H,Araki T

更新日期：2008-12-16 00:00:00

abstract：:Agrochemicals or pesticides are compounds widely used to prevent, destroy or mitigate pests such as insects, rodents, herbs and weeds. However, most of them also act as environmental estrogens, anti-estrogens and/or antiandrogenic chemicals. In addition, both herbicides (such as glyphosate and paraquat) and insecticid...

journal_title：Molecular and cellular endocrinology

authors： Rossetti MF,Stoker C,Ramos JG

更新日期：2020-06-15 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease in the vessel. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in atherogenesis. Although hyperaldosteronism is known to evoke inflammatory response in several tissues and cell types, there is no direct evidence to demonstrate the proin...

journal_title：Molecular and cellular endocrinology

authors： Zhang X,Liu J,Pang X,Zhao J,Wang S,Wu D

更新日期：2014-09-01 00:00:00

abstract：:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF...

journal_title：Molecular and cellular endocrinology

authors： Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

更新日期：2015-01-05 00:00:00

abstract：:Direct roles of follicle-stimulating hormone (FSH)-suppressing protein (FSP) and activin in regulation of ovarian granulosa cell differentiation have been reported recently. The present study further investigated the effects of these peptides on steroidogenesis and inhibin production as well as cAMP generation in cult...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK

更新日期：1991-08-01 00:00:00

abstract：:Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent isolated from Androgr...

journal_title：Molecular and cellular endocrinology

authors： Zhang M,Yang M,Wang N,Liu Q,Wang B,Huang T,Tong Y,Ming Y,Wong CW,Liu J,Yao D,Guan M

更新日期：2020-08-01 00:00:00

abstract：:Here we report the identification and characterization of ghrelin (GRLN) receptors in goldfish Carassius auratus. We identified four distinct mRNAs generated from four different genes. Those were roughly divided into two types, based on the number of amino acids and amino acid sequence similarity; one composed of 360-...

journal_title：Molecular and cellular endocrinology

authors： Kaiya H,Miura T,Matsuda K,Miyazato M,Kangawa K

更新日期：2010-10-07 00:00:00

abstract：:Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroe...

journal_title：Molecular and cellular endocrinology

authors： Vandenput L,Ohlsson C

更新日期：2014-01-25 00:00:00

abstract：:Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart AC,Goosen P,Swart P

更新日期：2013-05-22 00:00:00