Mammalian epididymal proteome.

abstract：:During development, the insulin-like growth factor I (IGF-I) gene is expressed in a tissue specific manner; however, the molecular mechanisms governing its developmental regulation remain poorly defined. To examine the hypothesis that expression of the growth hormone (GH) receptor accounts, in part, for the tissue spe...

journal_title：Molecular and cellular endocrinology

authors： Shoba L,An MR,Frank SJ,Lowe WL Jr

更新日期：1999-06-25 00:00:00

abstract：:Inhibitor-1 following phosphorylation by protein kinase A inhibits phosphoprotein phosphatase-1. We have found that in the rat heart inhibitor-1 is present only in the cytosolic fraction and that its phosphorylation in ventricular slices was increased by isoproterenol but not by isoproterenol and propranolol together....

journal_title：Molecular and cellular endocrinology

authors： Iyer RB,Koritz SB,Kirchberger MA

更新日期：1988-01-01 00:00:00

abstract：:There are multiple systems for cellular cholesterol delivery for steroidogenesis, including uptake of lipoprotein-derived cholesterol via LDL receptor mediated endocytic pathways and SR-BI mediated "selective" pathways, as well as from endogenous cholesterol synthesis and the mobilization of stored cholesteryl esters....

journal_title：Molecular and cellular endocrinology

authors： Kraemer FB

更新日期：2007-02-01 00:00:00

abstract：:Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesi...

journal_title：Molecular and cellular endocrinology

authors： Louw-du Toit R,Storbeck KH,Cartwright M,Cabral A,Africander D

更新日期：2017-02-05 00:00:00

abstract：:The effects of glucocorticoids on expression of the beta1-adrenergic receptor (beta1AR) gene have been varied. To study the mechanism underling hormonal regulation of the beta1AR, transient transfection of progressively deleted ovine beta1AR promoter fragments was used to identify a 43-bp region (-1274 to -1232 from t...

journal_title：Molecular and cellular endocrinology

authors： Tseng YT,Stabila JP,Nguyen TT,McGonnigal BG,Waschek JA,Padbury JF

更新日期：2001-07-05 00:00:00

abstract：:Recent evidence suggests that lymphocytes produce prolactin (PRL). Here, we report the cDNA cloning and expression of PRL from normal human thymocytes. Sequence analysis showed that the thymocyte cDNA encodes a 23 kDa protein which is identical to pituitary PRL. RNA blot analysis showed that the thymocyte PRL mRNA is ...

journal_title：Molecular and cellular endocrinology

authors： O'Neal KD,Montgomery DW,Truong TM,Yu-Lee LY

更新日期：1992-09-01 00:00:00

abstract：:The androgen receptor (AR) is a ligand-dependent transcription activator responsible for male sexual development. In order to specifically inhibit the AR pathway, dominant negative ARs were constructed by inactivation of the major transactivation domains of the wild type AR and fusing this mutant (AR122) to the Krüppe...

journal_title：Molecular and cellular endocrinology

authors： Bramlett KS,Dits NF,Sui X,Jorge MC,Zhu X,Jenster G

更新日期：2001-10-25 00:00:00

abstract：:Adenylate cyclase activity and its modulation by guanine nucleotides and isoproterenol were assessed in adipocyte membranes of mice with mutations causing different genetic obesity syndromes. The object was to determine whether the defect in inhibitory modulation observed in the obese (ob/ob) mouse was also present in...

journal_title：Molecular and cellular endocrinology

authors： Bégin-Heick N,Coleman DL

更新日期：1988-10-01 00:00:00

abstract：:Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], a...

journal_title：Molecular and cellular endocrinology

authors： Pathak V,Gault VA,Flatt PR,Irwin N

更新日期：2015-02-05 00:00:00

abstract：:Leptin, the adipocyte-derived hormone that plays a key role in body weight homeostasis, has recently emerged as a relevant neuroendocrine mediator in different systems, including the reproductive axis. Thus, compelling evidence points out a major role of leptin in the regulation of female pubertal development and fert...

journal_title：Molecular and cellular endocrinology

authors： Tena-Sempere M,Barreiro ML

更新日期：2002-02-25 00:00:00

abstract：:Polyamines are well-known ubiquitous components of living cells. Although these polycations have been implicated in the regulation of major cellular functions such as DNA, RNA and protein synthesis occurring during cellular proliferation and/or differentiation processes, their mechanism of action at the molecular leve...

journal_title：Molecular and cellular endocrinology

authors： Cochet C,Chambaz EM

更新日期：1983-06-01 00:00:00

abstract：:The free radical, or oxidative stress, theory posits that imbalance in cells between prooxidants and antioxidants results in an altered redox state and, over time, an accumulation of oxidative damage. We hypothesized herein that cells with an increasingly prooxidant intracellular environment also might be particularly...

journal_title：Molecular and cellular endocrinology

authors： Chen H,Zhou L,Lin CY,Beattie MC,Liu J,Zirkin BR

更新日期：2010-07-29 00:00:00

abstract：:We studied the functional properties of hepatic glucagon receptors during rat development. Glucagon binding to liver membranes and isolated hepatocytes was significantly less in foetuses and weaning rats than in adult animals, reflecting changes in the number of receptors rather than any change in receptor affinity fo...

journal_title：Molecular and cellular endocrinology

authors： Blázquez E,Perez Castillo A,de Diego JG

更新日期：1987-02-01 00:00:00

abstract：:Cultured rat anterior pituitary cells were continuously perfused with medium 199, and exposed to short (5 min), intermediate (30 min), or long (6 h) pulses of a maximally effective concentration of gonadotropin-releasing hormone (GnRH). Assay of the effluent by radioimmunoassay and interstitial-cell bioassay revealed ...

journal_title：Molecular and cellular endocrinology

authors： Naor Z,Katikineni M,Loumaye E,Vela AG,Dufau ML,Catt KJ

更新日期：1982-07-01 00:00:00

abstract：:The role of cannabinoid receptor I (CBR-1) in the induction of decidualization was examined using decidual fibroblasts and human endometrial stromal cells as model systems. Decidual fibroblasts decidualized in vitro for 3 and 6 days in the presence of the CBR-1 agonist R(+)-WIN 55,212-2 mesylate (WIN, 0.1-10 microM) e...

journal_title：Molecular and cellular endocrinology

authors： Moghadam KK,Kessler CA,Schroeder JK,Buckley AR,Brar AK,Handwerger S

更新日期：2005-01-14 00:00:00

abstract：:We used murine Ba/F3 cells transfected with human growth hormone receptor (hGHR) cDNA to investigate the regulatory mechanisms of human growth hormone-binding protein (hGH-BP) release. The extracellular domain of hGHRs were cleaved and released as hGH-BPs (a soluble form of hGHR). The hGH-BP release was enhanced by ph...

journal_title：Molecular and cellular endocrinology

authors： Takagi K,Saito Y,Sawada J

更新日期：2001-09-01 00:00:00

abstract：:The aim of our study was to investigate the direct effects of atypical antipsychotics on muscle cell functions in order to ascertain the diabetic liability of these drugs. We investigated the effects of olanzapine, clozapine and alpha-methyl-5-hydroxytryptamine on basal glucose uptake and glucose uptake in response to...

journal_title：Molecular and cellular endocrinology

authors： Tulipano G,Spano P,Cocchi D

更新日期：2008-09-24 00:00:00

abstract：:The glycoprotein hormones luteinizing hormone (LH) and human chorionic gonadotropin (hCG), both of which act through the LH receptor, play an important role in the regulation of both male and female gonadal function. Testicular androgen production by the Leydig cells is almost entirely dependent on LH/hCG action, whil...

journal_title：Molecular and cellular endocrinology

authors： Themmen AP,Martens JW,Brunner HG

更新日期：1998-10-25 00:00:00

abstract：:The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6...

journal_title：Molecular and cellular endocrinology

authors： van Haastert PJ,van Walsum H,van der Meer RC,Bulgakov R,Konijn TM

更新日期：1982-02-01 00:00:00

abstract：:While vitamin D supplementation is common, the anabolic mechanisms that improve bone status are poorly understood. Under standard mineralising conditions including media ionised calcium of 1.1 mM, 1,25-dihydroxyvitamin D3 (1,25D) enhanced differentiation and mineral deposition by the mature osteoblast/pre-osteocyte ce...

journal_title：Molecular and cellular endocrinology

authors： Yang D,Turner AG,Wijenayaka AR,Anderson PH,Morris HA,Atkins GJ

更新日期：2015-09-05 00:00:00

abstract：:To fully evaluate the advantages of a cryopreservation program a method needs to be established to express the additional patients pregnant from cryopreservation. The patient specific method considers cryopreservation as augmentation only among patients without a pregnancy from the fresh transfer, or from previously t...

journal_title：Molecular and cellular endocrinology

authors： Schnorr JA,Muasher SJ,Jones HW Jr

更新日期：2000-11-27 00:00:00

abstract：:Protein tyrosine kinases (PTKs) are key enzymes implicated in signal transduction pathways regulated by growth factors (GFs). We have previously shown by immunohistochemistry that the level of phosphotyrosine (pY) proteins is increased in prostatic basal epithelial cells following estrogen treatment in castrated dogs....

journal_title：Molecular and cellular endocrinology

authors： Allard P,Atfi A,Landry F,Chapdelaine A,Chevalier S

更新日期：1997-01-03 00:00:00

abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

journal_title：Molecular and cellular endocrinology

authors： Podesta EJ,Dufau ML,Catt KJ

更新日期：1976-06-01 00:00:00

abstract：:Glucocorticoids play a major role in attenuation of the inflammatory response. These steroid hormones are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages and T-lymphocytes that are involved in the inflammation reaction. In contrast, it was discovered recently that in glandu...

journal_title：Molecular and cellular endocrinology

authors： Amsterdam A,Sasson R

更新日期：2002-03-28 00:00:00

abstract：:Cells isolated enzymically from seminal vesicles and epididymides of normal and castrated rats were shown by electron microscopy to be intact and representative of the tissue. The cells synthesize and secrete tissue-specific proteins. Short-term incorporation of [3H]uridine and [35S]methionine was measured to determin...

journal_title：Molecular and cellular endocrinology

authors： Higgins SJ,Brooks DE,Fuller FM

更新日期：1981-08-01 00:00:00

abstract：:The expression of the gene coding for thyroperoxydase, the main enzyme involved in the synthesis of the thyroid hormones, is controlled by thyroid stimulating hormone. In vitro transcription assays performed on nuclei isolated from dog thyroid cells in primary culture showed that this control is at the transcription l...

journal_title：Molecular and cellular endocrinology

authors： Gerard CM,Lefort A,Libert F,Christophe D,Dumont JE,Vassart G

更新日期：1988-12-01 00:00:00

abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

journal_title：Molecular and cellular endocrinology

authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

更新日期：2016-11-15 00:00:00

abstract：:Prostate cancer (PCa) is a major health issue in the Western world. Current clinical imperatives for this disease include better stratification of indolent versus aggressive disease to enable improved patient management, as well as the identification of more effective therapies for the prevention and treatment of meta...

journal_title：Molecular and cellular endocrinology

authors： Das R,Feng FY,Selth LA

更新日期：2019-01-15 00:00:00

abstract：:The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following androgen treatment of LNCaP human prostate cancer cells led to the isolation of three new NEDD4L transcripts designated NEDD4Lf, NEDD4Lg and NEDD4Lh. The three...

journal_title：Molecular and cellular endocrinology

authors： Qi H,Grenier J,Fournier A,Labrie C

更新日期：2003-11-28 00:00:00

abstract：:In a model of pulmonary hypertension induced by a single injection of monocrotaline (MCT), we observed a time-dependent right ventricular hypertrophy, which became apparent in treated rats 21 days after administration of MCT and progressed through day 45. Associated with this right ventricular hypertrophy were time-de...

journal_title：Molecular and cellular endocrinology

authors： Oehlenschlager WF,Kurtz DT,Baron DA,Currie MG

更新日期：1989-04-01 00:00:00