The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis.


:Glucocorticoids play a major role in attenuation of the inflammatory response. These steroid hormones are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages and T-lymphocytes that are involved in the inflammation reaction. In contrast, it was discovered recently that in glandular cells such as the mammary gland epithelia, hepatocytes, ovarian follicular cells and in fibroblasts glucocorticoids protect against apoptotic signals evoked by cytokines, cAMP, tumor suppressors and death genes. The anti-apoptotic effect of glucocorticoids is exerted by modulation of several survival genes such as Bcl-2, Bcl-x(L) and NFkappaB, in a cell type-specific manner. Moreover, up regulation or down regulation of the same gene product can occur in a cell type-dependent manner following stimulation by glucocorticoids. This phenomenon is probably due to composite regulatory cross-talk among multiple nuclear coactivators or corepressors, which mediate the transcriptional regulation of the genes, by their interaction with the glucocorticoid receptor (GR). These observations suggest that the anti-inflammatory action of glucocorticoids is exerted by two complementary mechanisms: on the one hand, they induce death of the cells that provoke the inflammation, and on the other hand, they protect the resident cells of the inflamed tissue by arresting apoptotic signals.


Mol Cell Endocrinol


Amsterdam A,Sasson R





Has Abstract


2002-03-28 00:00:00














  • Progenitor cells in the embryonic anterior pituitary abruptly and concurrently depress mitotic rate before progressing to terminal differentiation.

    abstract::The control of progenitor cell proliferation in concert with terminal differentiation during embryonic development is poorly understood. The present paper examines this issue in the different cell lineages of the fetal mouse pituitary. Mouse fetuses were pulse-exposed to 3H-thymidine (3H-T) on a single day between emb...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Seuntjens E,Denef C

    更新日期:1999-04-25 00:00:00

  • Auto-regulation of estrogen receptor subtypes and gene expression profiling of 17beta-estradiol action in the neuroendocrine axis of male goldfish.

    abstract::Auto-regulation of the three goldfish estrogen receptor (ER) subtypes was examined simultaneously in multiple tissues, in relation to mRNA levels of liver vitellogenin (VTG) and brain transcripts. Male goldfish were implanted with a silastic implant containing either no steroid or 17beta-estradiol (E2) (100 microg/g b...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Marlatt VL,Martyniuk CJ,Zhang D,Xiong H,Watt J,Xia X,Moon T,Trudeau VL

    更新日期:2008-02-13 00:00:00

  • Expression of 17beta- and 3beta-hydroxysteroid dehydrogenases and steroidogenic acute regulatory protein in non-luteinizing bovine granulosa cells in vitro.

    abstract::Granulosa cells of small follicles differentiate in vitro in serum-free medium, resulting in increased estradiol secretion and abundance of mRNA encoding cytochrome P450aromatase (P450arom). We tested the hypothesis that differentiation in vitro also involves increased expression of 3beta- and 17beta-hydroxysteroid de...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Sahmi M,Nicola ES,Silva JM,Price CA

    更新日期:2004-08-31 00:00:00

  • Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation.

    abstract::alpha-Fetoprotein (AFP) is a serum protein expressed during fetal life, the expression of which is shut off after birth. The activity of the mouse Afp gene promoter region comprised between -80 and -38 bp is regulated by the thyroid hormone receptor (T3R): negatively in the presence of T3 and positively in the absence...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Van Reeth T,Gabant P,Szpirer C,Szpirer J

    更新日期:2002-02-25 00:00:00

  • Unraveling the estrogen receptor (er) genes in Atlantic salmon (Salmo salar) reveals expression differences between the two adult life stages but little impact from polychlorinated biphenyl (PCB) load.

    abstract::Estrogen receptors (ers) not only are activated by hormones but also interact with many human-derived environmental contaminants. Here, we present evidence for four expressed er genes in Atlantic salmon cDNA - two more ers (erα2 and erβ2) than previously published. To determine if er gene expression differs between tw...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Nikoleris L,Hansson MC

    更新日期:2015-01-15 00:00:00

  • A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.

    abstract::In the haematophagous insect, Rhodnius prolixus, a rapid diuresis following engorgement of vertebrate blood is under the control of two main diuretic hormones: a corticotropin-releasing factor (CRF)-related peptide andserotonin (5HT). A CAP2b (CAPA)-related peptide is involved in the termination of this diuresis, and ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Paluzzi JP,Orchard I

    更新日期:2010-04-12 00:00:00

  • Identification of multiple transcription start sites in the human insulin-like growth factor-I gene.

    abstract::We have localized four transcription initiation sites in the human insulin-like growth factor-I (IGF-I) gene. Two transcription start sites were identified which result in a longer and shorter version of the leader derived from the known exon 1 of the IGF-I gene. Transcription starting at the upstream transcription in...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Jansen E,Steenbergh PH,LeRoith D,Roberts CT Jr,Sussenbach JS

    更新日期:1991-06-01 00:00:00

  • The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion.

    abstract::The antimalarial agent, mefloquine, inhibits the function of connexin Cx36 gap junctions and hemichannels and has thus become a tool to investigate their physiological relevance in pancreatic islets. In view of earlier reports on a KATP channel-block by mefloquine, the specificity of mefloquine as a pharmacological to...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Seemann N,Welling A,Rustenbeck I

    更新日期:2018-09-05 00:00:00

  • Metabolism of hCG and hLH to multiple urinary forms.

    abstract::Human chorionic gonadotropin (hCG) is synthesized primarily in the placenta while human luteinizing hormone (hLH) is produced in the pituitary. Both hormones are highly homologous in structure and both appear to be altered to analogous molecular forms as the hormones are proteolytically processed, or metabolized, from...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审


    authors: Birken S,Kovalevskaya G,O'Connor J

    更新日期:1996-12-20 00:00:00

  • Cytochrome b5: novel roles in steroidogenesis.

    abstract::Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审


    authors: Storbeck KH,Swart AC,Goosen P,Swart P

    更新日期:2013-05-22 00:00:00

  • Ets-1 activates parathyroid hormone-related protein gene expression in tumorigenic breast epithelial cells.

    abstract::Parathyroid hormone-related protein (PTHrP) is produced by many tumors not associated with humoral hypercalcemia, including breast cancers. In this study, we used three human immortalized mammary epithelial cell lines that differ in tumorigenicity and PTHrP expression. Using RT-PCR we investigated 5' and 3' alternativ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Cataisson C,Gordon J,Roussière M,Abdalkhani A,Lindemann R,Dittmer J,Foley J,Bouizar Z

    更新日期:2003-06-30 00:00:00

  • Effects of activin A on anterior pituitary cells fractionated by centrifugal elutriation.

    abstract::We have shown previously that activin A increases the number of immunoreactive follicle-stimulating hormone (FSH) cells. To further investigate the action of activin A, we examined its effects on anterior pituitary cells fractionated by centrifugal elutriation. Before activin A treatment, FSH cells were widely distrib...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Katayama T,Shiota K,Takahashi M

    更新日期:1991-05-01 00:00:00

  • Exon-specific northern analysis and rapid amplification of cDNA ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P450 (CYP19) expression in human ovary.

    abstract::Estrogens are synthesized from C19 steroids by a unique form of cytochrome P450, aromatase cytochrome P-450 (P-450AROM; the product of the CYP19 gene). We have shown that tissue-specific expression of human P-450AROM is determined, in part, by the use of alternative promoters. Previous methods of analysis for determin...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Jenkins C,Michael D,Mahendroo M,Simpson E

    更新日期:1993-11-01 00:00:00

  • Expression localization of Bmi1 in mice testis.

    abstract::B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), known as the first functional member of PcG (Polycomb Group) family, is supposed to be a key regulator of stem cell self-proliferation. In this study, we investigated its expression in testis and its impact on spermatogonia proliferation for bet...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Zhang S,Li D,Li E,Li L,Wang J,Wang C,Lu J,Zhang X

    更新日期:2008-06-11 00:00:00

  • Epitope-tagged gonadotropin-releasing hormone receptors heterologously-expressed in mammalian (COS-1) and insect (Sf9) cells.

    abstract::The molecular cloning and nucleotide sequencing of the gonadotropin-releasing hormone (GnRH) receptor represented an enhanced step in the experimental effort to understand this key molecule in the reproductive process at a cell and molecular level. A subsequent step in this broad effort is heterologous expression of t...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Neill JD,Sellers JC,Musgrove LC,Duck LW

    更新日期:1997-03-28 00:00:00

  • Multigenic control of thyroid hormone functions in the nervous system.

    abstract::Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated by alpha and beta isoforms of TH receptor which act as ligand-regulate...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审


    authors: Nunez J,Celi FS,Ng L,Forrest D

    更新日期:2008-06-11 00:00:00

  • Specific binding of 20-hydroxyecdysone to nuclei of imaginal discs of Drosophila melanogaster.

    abstract::Specific binding of the insect steroid hormone 20-hydroxyecdysone to imaginal discs of Drosophila melanogaster has been investigated. Evidence is presented showing that most of the specific binding is located in the nuclear fraction at the time changes in gene function are observed. Nuclear binding is high affinity, a...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Yund MA

    更新日期:1979-04-01 00:00:00

  • PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells.

    abstract::Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and growth in others. We examined whether PTHrP production is greater in well-differentiated or growing beta cells and whether PTHrP induces differentiation or growth in...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Sawada Y,Zhang B,Okajima F,Izumi T,Takeuchi T

    更新日期:2001-09-01 00:00:00

  • New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes.

    abstract::A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increas...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Fujimori C,Ogiwara K,Hagiwara A,Takahashi T

    更新日期:2012-10-15 00:00:00

  • Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.

    abstract::In the characterization of newly identified proteins, subcellular localization studies can provide important hints to the proteins' metabolic functions. Depending on the biochemical task of an enzyme, certain subcellular environmental conditions as pH or availability of cofactors and substrates have to be fulfilled. C...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Keller B,Meier M,Adamski J

    更新日期:2009-03-25 00:00:00

  • Differential expression and localisation of connexin-37 and connexin-43 in follicles of different stages in the 4-week-old mouse ovary.

    abstract::Mammalian female fertility is critically dependent on timely coordinated intercellular communication between follicle cells. Gap junctions are small, membrane-bound, aqueous channels that couple adjacent cells ionically and gap junction proteins, connexin-37 (Cx37) and connexin-43 (Cx43) both participate in sustaining...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Teilmann SC

    更新日期:2005-04-29 00:00:00

  • Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling.

    abstract::Vitamin D is a key factor for calcium and bone homeostasis, but signalling through the vitamin D receptor (VDR) seems also to be important for testicular function. To test the functional role of vitamin D signalling we examined the male reproductive system of the Leuven Vdr-ablated (Vdr(-/-)) mice, previously establis...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Blomberg Jensen M,Lieben L,Nielsen JE,Willems A,Jørgensen A,Juul A,Toppari J,Carmeliet G,Rajpert-De Meyts E

    更新日期:2013-09-05 00:00:00

  • Effect of transfer RNA from various sources on placental messenger RNA translation.

    abstract::Poly(A+)-containing mRNA from human term placenta was used to direct protein synthesis in a nuclease-treated rabbit reticulocyte lysate, which is dependent on mRNA and tRNA for maximal activity. The major protein product was human pre-placental lactogen (hPL). Addition of tRNA from rabbit liver, rabbit reticulocyte, h...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Kelly SJ,Loria J,Gyves MT,Ilan J

    更新日期:1983-02-01 00:00:00

  • Brain sex matters: estrogen in cognition and Alzheimer's disease.

    abstract::Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审


    authors: Li R,Cui J,Shen Y

    更新日期:2014-05-25 00:00:00

  • Upstream open reading frames regulate cannabinoid receptor 1 expression under baseline conditions and during cellular stress.

    abstract::The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

    更新日期:2015-01-05 00:00:00

  • AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

    abstract::Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by progesterone or synthetic progestins. Estrogen and progestin action is regulated at the pre-receptor level, by interconversion of active hormones (estradiol (E2), prog...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Rizner TL,Smuc T,Rupreht R,Sinkovec J,Penning TM

    更新日期:2006-03-27 00:00:00

  • Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos.

    abstract:OBJECTIVES:The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos. METHODS:The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched bl...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Sato N,Kawamura K,Fukuda J,Honda Y,Sato T,Tanikawa H,Kodama H,Tanaka T

    更新日期:2003-04-28 00:00:00

  • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells.

    abstract::While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Thoennes SR,Tate PL,Price TM,Kilgore MW

    更新日期:2000-02-25 00:00:00

  • Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.

    abstract::Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential h...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章,评审


    authors: Monticone S,Else T,Mulatero P,Williams TA,Rainey WE

    更新日期:2015-01-05 00:00:00

  • The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease.

    abstract::Insulin receptor substrate-1 (IRS-1) is a protein expressed in 3T3-L1 adipocytes that is involved in most, if not all of the biological responses to insulin. Chronic exposure of these cells to insulin down-regulates IRS-1 by stimulating its degradation (Rice, K.M., Turnbow, M.A. and Garner, C.W. (1993) Biochem. Biophy...

    journal_title:Molecular and cellular endocrinology

    pub_type: 杂志文章


    authors: Smith LK,Rice KM,Garner CW

    更新日期:1996-08-30 00:00:00