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Improvement of human pancreatic islet quality after co-culture with human adipose-derived stem cells.

Abstract：

:The aim of this study was to investigate whether co-culture of human islets with adipose-derived stem cells (ASCs) can improve islet quality and to evaluate which factors play a role in the protective effect of ASCs against islet dysfunction. Islets and ASCs were cultured in three experimental groups for 24 h, 48 h, and 72 h: 1) indirect co-culture of islets with ASC monolayer (Islets/ASCs); 2) islets alone; and 3) ASCs alone. Co-culture with ASCs improved islet viability and function in all culture time-points analyzed. VEGFA, HGF, IL6, IL8, IL10, CCL2, IL1B, and TNF protein levels were increased in supernatants of islet/ASC group compared to islets alone, mainly after 24 h. Moreover, VEGFA, IL6, CCL2, HIF1A, XIAP, CHOP, and NFKBIA genes were differentially expressed in islets from the co-culture condition compared to islets alone. In conclusion, co-culture of islets with ASCs promotes improvements in islet quality.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

de Souza BM,Rodrigues M,de Oliveira FS,da Silva LPA,Bouças AP,Portinho CP,Dos Santos BP,Camassola M,Rocha D,Lysakowski S,Martini J,Leitão CB,Nardi NB,Bauer AC,Crispim D

doi

10.1016/j.mce.2020.110729

subject

Has Abstract

pub_date

2020-04-05 00:00:00

pages

110729

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(20)30029-0

journal_volume

505

pub_type

杂志文章

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