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Gonadal steroid modulation of LHRH-stimulated LH secretion by pituitary cell cultures.

Abstract：

:Enzymatically dispersed rat pituitary cells were grown in primary culture, and LHRH-stimulated LH secretion was measured. Testosterone (T) decreased and 17 beta-estradiol (E) increased pituitary responsiveness to LHRH. The effect of E on LH secretion was partly due to an increase in LH content. There was a latent period of 12 h for E and 18 h for T between the onset of steroid treatment and the manifestation of steroid action. Neither steroid was required to be continuously present in order to exert its effects. After steroid withdrawal, the effect of T persisted for 72 h and that of E for more than 96 h. The actions of both steroids were blocked by protein-synthesis inhibitors. These results are consistent with the hypothesis that steroid effects rely on a mechanism involving alterations in protein synthesis; the affected proteins may be involved in the process of LHRH action.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Kamel F,Krey LC

doi

10.1016/0303-7207(82)90013-2

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

151-64

issue

1-2

eissn

0303-7207

issn

1872-8057

journal_volume

26

pub_type

杂志文章

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