TSH stimulates the activity of the c-fos promoter in FRTL5 rat thyroid cells.

abstract：:To determine if the hormonal effects on insulin-like growth factor binding protein (IGFBP) production differed between granulosa and thecal cells, both cell types were collected and cultured in serum-free medium with various hormone treatments, arranged in three experiments. Following treatment, cells were enumerated ...

journal_title：Molecular and cellular endocrinology

authors： Chamberlain CS,Spicer LJ

更新日期：2001-08-20 00:00:00

abstract：:The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR α and PPAR β/δ activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742-pharmacological activators of PPAR ...

journal_title：Molecular and cellular endocrinology

authors： Regueira M,Riera MF,Galardo MN,Pellizzari EH,Cigorraga SB,Meroni SB

更新日期：2014-01-25 00:00:00

abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

journal_title：Molecular and cellular endocrinology

authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1989-06-01 00:00:00

abstract：:At the early stage of its development in 1957, the daily dose of spironolactone necessary to improve various pathological conditions was not precisely determined and dose-dependent sexual side effects limited its long-term use. Prescription of high daily doses and absence of selectivity for the mineralocorticoid recep...

journal_title：Molecular and cellular endocrinology

authors： Ménard J

更新日期：2004-03-31 00:00:00

abstract：:Bone tissue is especially receptive to physical stimulation and agents with the capacity to mimic the signalling incurred via mechanical loading on osteoblasts may find an application in a bone regenerative setting. Recently this laboratory revealed that the major serum lipid, lysophosphatidic acid (LPA), co-operated ...

journal_title：Molecular and cellular endocrinology

authors： Mansell JP,Farrar D,Jones S,Nowghani M

更新日期：2009-06-16 00:00:00

abstract：:The direct inhibitory of gonadotropin-releasing hormone (GnRH) upon testicular androgen production was studied in cultured testicular cells. Enzyme-dispersed testicular cells from immature hypophysectomized rats were cultured for 6 days in a serum-free medium with or without various hormones. Culture media were change...

journal_title：Molecular and cellular endocrinology

authors： Hsueh AJ,Schreiber JR,Erickson GF

更新日期：1981-01-01 00:00:00

abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

journal_title：Molecular and cellular endocrinology

authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

更新日期：1999-11-25 00:00:00

abstract：:Human type II iodothyronine deiodinase (hDII) belongs to a family of selenoproteins. It catalyzes 5'-deiodination of thyroxine to generate an active thyroid hormone, 3,3',5-triiodothyronine. Two novel splice variants of hDII gene transcript; namely hDII-b and hDII-c, were identified. Three distinct DNA fragments (hDII...

journal_title：Molecular and cellular endocrinology

authors： Ohba K,Yoshioka T,Muraki T

更新日期：2001-02-14 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) accumulates in the environment, and its exposure is possibly associated with endocrine-related disease in women of reproductive age. The effects of DEHP on human endometrial cells are unknown. We treated human endometrial stromal cells with 10, 100, and 1000 pmol of DEHP and measured...

journal_title：Molecular and cellular endocrinology

authors： Cho YJ,Park SB,Han M

更新日期：2015-05-15 00:00:00

abstract：:The earliest known induction by estrogen of a specific uterine protein is that of the induced protein (IP) of Gorski and colleagues, which is demonstrable within 40 min after treatment. We found that this protein is not restricted to the rat; it was detected i the uterus of prepuberal C3H/eB and SWR mice, 1 h after i...

journal_title：Molecular and cellular endocrinology

authors： Sömjen D,Kaye AM

更新日期：1976-05-01 00:00:00

abstract：:Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], a...

journal_title：Molecular and cellular endocrinology

authors： Pathak V,Gault VA,Flatt PR,Irwin N

更新日期：2015-02-05 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:Loss of ovarian function has important effects on neurotransmitter production and release with corresponding effects on cognitive performance. To date, there has been little direct comparison of the effects of surgical and transitional menopause on neurotransmitter pathways in the brain. In this study, effects on mono...

journal_title：Molecular and cellular endocrinology

authors： Long T,Yao JK,Li J,Kirshner ZZ,Nelson D,Dougherty GG,Gibbs RB

更新日期：2018-11-15 00:00:00

abstract：:In an effort to identify the signal transduction mechanism associated with the inhibition of juvenile hormone (JH) biosynthesis by the neuropeptides allatostatins, levels of the cyclic nucleotides cAMP and cGMP were measured in corpora allata (CA) of virgin and mated Diploptera punctata females using radioimmunoassays...

journal_title：Molecular and cellular endocrinology

authors： Cusson M,Yagi KJ,Guan XC,Tobe SS

更新日期：1992-11-01 00:00:00

abstract：:The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR g...

journal_title：Molecular and cellular endocrinology

authors： Henrohn D,Le Grevés P,Nyberg F

更新日期：1997-12-12 00:00:00

abstract：:The aim of this work was to determine whether treatments of rats with estradiol (E) in conditions known to decrease the proliferation rate, the mitotic index and the thymidine incorporation into the DNA of the MtTF4 tumor act at a specific point in the cell cycle. Two weeks after grafting a piece of tumor under the ki...

journal_title：Molecular and cellular endocrinology

authors： Pharaboz MO,Cordier G,André J

更新日期：1986-12-01 00:00:00

abstract：:Epigenetic methodologies address mechanisms of estrogenic effects on hypothalamic and preoptic neurons, as well as mechanisms by which stress can interfere with female reproductive behaviors. Recent results are reviewed. ...

journal_title：Molecular and cellular endocrinology

authors： Pfaff DW,Gagnidze K,Hunter RG

更新日期：2018-05-15 00:00:00

abstract：:The canonical renin-angiotensin system (RAS) involves the initial action of renin to cleave angiotensinogen to angiotensin I (ANG I), which is then converted to ANG II by the angiotensin converting enzyme (ACE). ANG II plays a critical role in numerous physiological functions, and RAS overactivity underlies many condi...

journal_title：Molecular and cellular endocrinology

authors： Henriksen EJ,Prasannarong M

更新日期：2013-09-25 00:00:00

abstract：:In vitro RNA synthesis has been analyzed using autoradiographic and electrophoretic methods in isolated 1-2 mm segments of rat seminiferous tubules. The cellular composition of each segment was accurately identified using microscopic analysis of the transillumination pattern of the freshly isolated, unstained, seminif...

journal_title：Molecular and cellular endocrinology

authors： Söderström KO,Parvinen M

更新日期：1976-08-01 00:00:00

abstract：:Adipose tissue develops from differentiating preadipocytes that expand and migrate. 3T3-L1 preadipocytes respond to melanin-concentrating hormone (MCH) by increasing leptin production. Here, we investigate whether MCH elicits remodeling of the actin cytoskeleton and whether this translates into altered migratory capac...

journal_title：Molecular and cellular endocrinology

authors： Cook LB,Shum L,Portwood S

更新日期：2010-05-14 00:00:00

abstract：:Many genes that are required for fertility have been identified in model organisms (). Mutations in these genes cause infertility due to defects in development of the germ cell lineage, but the organism is otherwise healthy. Although human reproduction is undoubtedly as complex as that of other organisms, very few fer...

journal_title：Molecular and cellular endocrinology

authors： Fox MS,Reijo Pera RA

更新日期：2001-11-26 00:00:00

abstract：:Presently, a growing interest is focused on the origins of the "Metabolic Syndrome", a cluster of several metabolic disorders linking obesity, dyslipidemia, hypertension and type 2 diabetes mellitus. Clearly, genetic predisposition and deleterious lifestyle, including low physical activity and hypercaloric alimentatio...

journal_title：Molecular and cellular endocrinology

authors： Somm E,Schwitzgebel VM,Vauthay DM,Aubert ML,Hüppi PS

更新日期：2009-05-25 00:00:00

abstract：:Some environmental contaminants and pharmaceuticals increase the incidence of uterine tumors in toxicological studies with rats. These tumors can result from a hormonal imbalance due to rat-specific disrupted pituitary prolactin regulation, and are therefore of questionable relevance for humans. In this study we compa...

journal_title：Molecular and cellular endocrinology

authors： van den Brand AD,Rubinstein E,van den Berg M,van Duursen MBM

更新日期：2019-10-01 00:00:00

abstract：:Rapid, nongenomic in vitro effects of aldosterone on intracellular electrolytes, cell volume and the sodium-proton antiporter have been found in human mononuclear leukocytes (HML), as have related membrane receptors. In the present study, binding of 125I-labeled aldosterone to plasma membrane preparations from pig kid...

journal_title：Molecular and cellular endocrinology

authors： Christ M,Sippel K,Eisen C,Wehling M

更新日期：1994-03-01 00:00:00

abstract：:This study examines the effect of FSH, testosterone and estradiol on testicular LH receptors and in vitro testicular responsiveness to LH in immature rats under various conditions. FSH treatment of 15-day-old immature rats significantly increased the number of LH receptors but did not alter testicular responsiveness. ...

journal_title：Molecular and cellular endocrinology

authors： Chen YD,Shaw MJ,Payne AH

更新日期：1977-10-01 00:00:00

abstract：:The orphan nuclear receptor steroidogenic factor 1 (SF-1) was identified originally as a key regulator of the tissue-specific expression of the cytochrome P450 steroid hydroxylases. Hints at considerably broader roles for SF-1 came from analyses of its expression pattern in mouse embryos. As anticipated, SF-1 was expr...

journal_title：Molecular and cellular endocrinology

authors： Hanley NA,Ikeda Y,Luo X,Parker KL

更新日期：2000-05-25 00:00:00

abstract：:Differences in sialic acid content of the hormone have been considered the main determinant of FSH polymorphism. The aim of the present study was to investigate the effect of variations in the oligosaccharide structure of the intrapituitary human FSH (hFSH) glycosylation variants on their intrinsic biological activity...

journal_title：Molecular and cellular endocrinology

authors： Creus S,Chaia Z,Pellizzari EH,Cigorraga SB,Ulloa-Aguirre A,Campo S

更新日期：2001-03-28 00:00:00

abstract：:Chronic restraint stress (CRS) magnifies restraint-induced corticosterone secretion through a mechanism involving increased adrenocortical 5-HT content and turnover. We analysed the impact of CRS on serotonin transporter (SERT) expression and distribution in rat adrenal glands. Male Wistar rats were submitted to CRS (...

journal_title：Molecular and cellular endocrinology

authors： Shanker S,Saroj N,Cordova EJ,Jarillo-Luna RA,López-Sánchez P,Terrón JA

更新日期：2020-12-01 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00

abstract：:Studies on the age-related decline of growth hormone (GH) release have ignored that the population of GH-producing cells (somatotropes) is heterogeneous. In aging male rats, centrifugation of dispersed pituitary cells in a density gradient yields two somatotrope subpopulations, i.e. low- (LD) and high-density (HD) cel...

journal_title：Molecular and cellular endocrinology

authors： Dobado-Berrios PM,Ruiz-Navarro A,Lopez-Pedrera R,Gonzalez de Aguilar JL,Torronteras R,Hidalgo-Diaz C,Gracia-Navarro F

更新日期：1996-10-30 00:00:00