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Chronic restraint stress induces serotonin transporter expression in the rat adrenal glands.

Abstract：

:Chronic restraint stress (CRS) magnifies restraint-induced corticosterone secretion through a mechanism involving increased adrenocortical 5-HT content and turnover. We analysed the impact of CRS on serotonin transporter (SERT) expression and distribution in rat adrenal glands. Male Wistar rats were submitted to CRS (20 min/day) or undisturbed control conditions for 14 days. Exposure to CRS induced a remarkable increase in SERT-like immunoreactivity in the adrenal cortex, which closely matched that of chromogranin A immunostaining, along with a significant increase in SERT protein and mRNA levels in whole adrenals as determined by immunohistochemistry, Western blot and RT-PCR assays, respectively; all these CRS-induced changes occurred almost exclusively in left adrenals. Closely similar results were obtained in animals that received a 14-day chronic corticosterone treatment. These results unravel an interesting association between chronic stress exposure and SERT expression in adrenocortical chromogranin A-positive cells, which seems to be a glucocorticoid-dependent phenomenon.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Shanker S,Saroj N,Cordova EJ,Jarillo-Luna RA,López-Sánchez P,Terrón JA

doi

10.1016/j.mce.2020.110935

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

110935

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(20)30235-5

journal_volume

518

pub_type

杂志文章

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