Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC.

abstract：:The function of the major adrenal steroid dehydroepiandrosterone (DHEA) is not known. It has been reported to improve learning and memory in mice and can exert neuroprotective and trophic effects, particularly in the hippocampus. We recently described a cytochrome P450 (Cyp7b), that catalyses the 7alpha-hydroxylation ...

journal_title：Molecular and cellular endocrinology

authors： Bean R,Seckl JR,Lathe R,Martin C

更新日期：2001-03-28 00:00:00

abstract：:The ovulatory process is characterized by tissue wounding and, after oocyte expulsion, by healing being connected to the formation of a corpus luteum (CL). The ovulatory event thus compares with a sterile inflammation. The concept is forwarded that the ovulatory process depends on innate immunity (INIM) function. The ...

journal_title：Molecular and cellular endocrinology

authors： Spanel-Borowski K

更新日期：2011-02-10 00:00:00

abstract：:Skeletal muscle is the major site of postprandial glucose disposal and augmenting glucose uptake into this tissue may attenuate insulin resistance that precedes type 2 diabetes mellitus. Here, we investigated the effect of pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and...

journal_title：Molecular and cellular endocrinology

authors： Tamrakar AK,Jaiswal N,Yadav PP,Maurya R,Srivastava AK

更新日期：2011-06-06 00:00:00

abstract：:Testicular peritubular cells produce paracrine mediators which modulate Sertoli cell function. The production of these mediators (P Mod-S) is controlled by androgens suggesting that mesenchymal-epithelial interactions play an important role in androgen action in the testis. We investigated whether mesenchymal cells fr...

journal_title：Molecular and cellular endocrinology

authors： Swinnen K,Cailleau J,Heyns W,Verhoeven G

更新日期：1989-03-01 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1-5). GnRH-(1-5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1-5) acts on the orphan G protein-coupled...

journal_title：Molecular and cellular endocrinology

authors： Cho-Clark M,Larco DO,Zahn BR,Mani SK,Wu TJ

更新日期：2015-11-05 00:00:00

abstract：:Key reproductive events, such as menstruation and implantation, are considered to be inflammatory processes and glucocorticoids act as anti-inflammatory agents. The balance of expression of types 1 and 2 11beta-hydroxysteroid dehydrogenases (11betaHSD) controls the availability of cortisol to bind to the glucocorticoi...

journal_title：Molecular and cellular endocrinology

authors： McDonald SE,Henderson TA,Gomez-Sanchez CE,Critchley HO,Mason JI

更新日期：2006-03-27 00:00:00

abstract：:Thyroid hormones suppress transcription of the gene for the beta-subunit of thyrotropin (TSH beta). Since the TSH beta gene in both the mouse and the rat contains two start sites of transcription in exon 1, we have investigated whether expression of the gene from each start site is differentially regulated by thyroid ...

journal_title：Molecular and cellular endocrinology

authors： Gurr JA,Januszeski MM,Tidikis IM,Norcross JJ,Kourides IA

更新日期：1990-07-09 00:00:00

abstract：:LH and FSH act on gonadal cells to regulate steroidogenesis and gametogenesis. To model human reproductive disorders involving loss of LH function and to define LH-responsive genes, we produced knockout mice lacking the hormone-specific LHbeta subunit. LHbeta null mice are viable but demonstrate postnatal defects in g...

journal_title：Molecular and cellular endocrinology

authors： Kumar TR

更新日期：2007-04-15 00:00:00

abstract：:A cell culture line has been derived from lymphosarcoma P1798. Cells will not divide in the prescence of 10(-8) M dexamethasone. Half-maximal inhibition of proliferation occurs at about 10(-9) M. Half-maximal inhibition of [3H] thymidine incorporation occurs at somewhat higher concentrations of dexamethasone. When cel...

journal_title：Molecular and cellular endocrinology

authors： Thompson EA Jr

更新日期：1980-02-01 00:00:00

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:The proliferative effect of estrogens on breast cancer cell (BCC) is mainly mediated through estrogen receptors (ER). Non-transcriptional effects of estrogens, exerted through activation of several protein kinases, may also contribute to BCC proliferation. However, the relative contribution of these two responses to B...

journal_title：Molecular and cellular endocrinology

authors： Geffroy N,Guédin A,Dacquet C,Lefebvre P

更新日期：2005-06-15 00:00:00

abstract：:The mechanisms that control the onset of puberty remain within the purview of the neurobiologists who first recognised the concept of removal of a restraint factor to permit reawakening of puberty. The discovery of a ligand-activated G protein receptor-signalling pathway upstream of the GnRH pulse generator adds furth...

journal_title：Molecular and cellular endocrinology

authors： Hughes IA,Kumanan M

更新日期：2006-07-25 00:00:00

abstract：:Developmental signalling pathways are implicated in the formation and maintenance of the adrenal gland, but their roles are currently not well defined. In recent years it has emerged that Sonic hedgehog (Shh) and Wnt/β catenin signalling are crucial for the growth and development of the adrenal cortex. Here we demonst...

journal_title：Molecular and cellular endocrinology

authors： Guasti L,Candy Sze WC,McKay T,Grose R,King PJ

更新日期：2013-05-22 00:00:00

abstract：:Somatostatin (SS) and its synthetic analogs have a role in the treatment of neuroendocrine tumours both in terms of symptoms control and antiproliferative activities. These effects are mediated by five SS receptors, widely expressed in both human neuroendocrine and non-neuroendocrine tumours, which were demonstrated t...

journal_title：Molecular and cellular endocrinology

authors： Volante M,Rosas R,Allìa E,Granata R,Baragli A,Muccioli G,Papotti M

更新日期：2008-05-14 00:00:00

abstract：:Photo-affinity labelling of MSH receptors on tail-fin melanophores of Xenopus tadpoles with p-azidophenylalanine 13-alpha-MSH (Pap13)-alpha-MSH) or p-azidophenylacetyl-serine1-alpha-MSH ([Apac-Ser1]-alpha-MSH) resulted in a long-lasting stimulation of the melanophores which cannot be reversed despite continuous washin...

journal_title：Molecular and cellular endocrinology

authors： de Graan PN,Eberle AN,van de Veerdonk FC

更新日期：1982-05-01 00:00:00

abstract：:Isolated islets were either studied immediately after isolation (fresh; F), or were cultured for 6 days at 11 mM glucose (desensitized; D), or were incubated for 2 h at 5.5 mM glucose following D (recovered; R). Glucose-stimulated insulin secretion in D islets was reduced compared with F and R islets. In the presence ...

journal_title：Molecular and cellular endocrinology

authors： Laychock SG

更新日期：1995-08-30 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:Immature female rats were injected with a single dose (10 IU) of pregnant mare serum gonadotropin to induce growth and maturation of ovarian follicles. Using such ovaries as a model, we tested the effects of low molecular weight subfractions of charcoal-absorbed bovine follicular fluid (FF-c) on (a) radioiodinated hum...

journal_title：Molecular and cellular endocrinology

authors： Fletcher PW,Dias JA,Sanzo MA,Reichert LE Jr

更新日期：1982-03-01 00:00:00

abstract：:Calcium is a second messenger responsible for regulating a wide range of cellular processes. It is normally presented as brief spikes even in non-excitable cells. The necessity of limiting the period of calcium stimulation to brief bursts may depend upon the fact that prolonged elevation of calcium can be toxic. It ca...

journal_title：Molecular and cellular endocrinology

authors： Berridge MJ

更新日期：1994-01-01 00:00:00

abstract：:In type 2 diabetes, a strong correlation between intramyocellular lipid accumulation and insulin resistance exists but whether intramyocellular accumulation is a cause or a consequence of insulin resistance is not clear. Lipid accumulation and response to insulin were evaluated in primary human myotubes derived from n...

journal_title：Molecular and cellular endocrinology

authors： Aguer C,Mercier J,Kitzmann M

更新日期：2010-02-05 00:00:00

abstract：:Vitamin D is a key factor for calcium and bone homeostasis, but signalling through the vitamin D receptor (VDR) seems also to be important for testicular function. To test the functional role of vitamin D signalling we examined the male reproductive system of the Leuven Vdr-ablated (Vdr(-/-)) mice, previously establis...

journal_title：Molecular and cellular endocrinology

authors： Blomberg Jensen M,Lieben L,Nielsen JE,Willems A,Jørgensen A,Juul A,Toppari J,Carmeliet G,Rajpert-De Meyts E

更新日期：2013-09-05 00:00:00

abstract：:This study was aimed at testing the hypothesis that epidermal growth factor (EGF) can modulate the gonadotropin-dependent differentiation of theca-interstitial cells in vitro. Addition of EGF to chemically defined culture medium severely antagonized the ability of hCG to transform undifferentiated theca-interstitial c...

journal_title：Molecular and cellular endocrinology

authors： Erickson GF,Case E

更新日期：1983-07-01 00:00:00

abstract：:We find that completion of the first meiotic division in Rana pipiens oocytes requires the sequential action of at least two steroids: progesterone and one or more subsequent polar metabolites of progesterone. Progesterone binding in vitro to oocyte surface receptors increases during the first 4-5h of exposure, follow...

journal_title：Molecular and cellular endocrinology

authors： Kostellow AB,Morrill GA

更新日期：2008-09-10 00:00:00

abstract：:Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian vertebrates including birds. In this study, the full-length cDNAs en...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Huang G,Li J,Meng F,He X,Leung FC

更新日期：2012-01-02 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a main factor promoting neovascularization (angiogenesis) of solid tumours as prostate carcinoma. Hypoxia stimulates VEGF gene expression by activating the hypoxia-inducible factor-1 (HIF-1alpha). In the present study, the hypoxia-mimicking agent Ni(2+) induced vasoactive i...

journal_title：Molecular and cellular endocrinology

authors： Collado B,Sánchez-Chapado M,Prieto JC,Carmena MJ

更新日期：2006-04-25 00:00:00

abstract：:The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6...

journal_title：Molecular and cellular endocrinology

authors： van Haastert PJ,van Walsum H,van der Meer RC,Bulgakov R,Konijn TM

更新日期：1982-02-01 00:00:00

abstract：:We review in this article recent findings on the effects of cell proximity (nearness to each other) on anterior pituitary cell function in vitro. Important cellular processes, including protein synthesis, basal hormone release, response to hypothalamic regulatory factors and signal transduction can change as a functio...

journal_title：Molecular and cellular endocrinology

authors： Perez FM,Rose JC,Schwartz J

更新日期：1995-06-01 00:00:00

abstract：:The interaction between thyroid microsomal autoantibodies and thyroid microsomal antigen/thyroid peroxidase (TPO) has been studied using both intact antigen preparations and their water-soluble trypsin fragments. In an analysis of sera from 30 patients with Graves' or Hashimoto's diseases, microsomal antibodies showed...

journal_title：Molecular and cellular endocrinology

authors： Nakajima Y,Howells RD,Pegg C,Jones ED,Smith BR

更新日期：1987-09-01 00:00:00

abstract：:During critical periods of development, hypothyroidism causes abnormalities of the central nervous system such as incomplete maturation of neuronal and glial cells, reduction in synaptic densities and myelin deficits. In this study expression of development regulated genes, ie transcription of beta-actin, sema 3F, CRM...

journal_title：Molecular and cellular endocrinology

authors： Wong CC,Leung MS

更新日期：2001-11-26 00:00:00