Anterior pituitary cells: getting to know their neighbors.

abstract：:17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant e...

journal_title：Molecular and cellular endocrinology

authors： Breitling R,Krazeisen A,Möller G,Adamski J

更新日期：2001-01-22 00:00:00

abstract：:In human granulosa-lutein cells, high-density lipoproteins (HDL) can stimulate progesterone synthesis. The objective of the present study was to establish whether prostaglandins (PGs) participate in the steroidogenic response to HDL. Both HDL and apolipoprotein AI (ApoAI) stimulated concentration-dependent increases i...

journal_title：Molecular and cellular endocrinology

authors： Chandras C,Ragoobir J,Barrett GE,Bruckdorfer KR,Graham A,Abayasekara DR,Michael AE

更新日期：2004-07-30 00:00:00

abstract：:In the haematophagous insect, Rhodnius prolixus, a rapid diuresis following engorgement of vertebrate blood is under the control of two main diuretic hormones: a corticotropin-releasing factor (CRF)-related peptide andserotonin (5HT). A CAP2b (CAPA)-related peptide is involved in the termination of this diuresis, and ...

journal_title：Molecular and cellular endocrinology

authors： Paluzzi JP,Orchard I

更新日期：2010-04-12 00:00:00

abstract：:Recently, a remarkable progress has been made in our understanding about the role of sex steroids in male physiology. In this paper, we consider the clinical aspects of congenital estrogen deficiency - notably, estrogen resistance and aromatase deficiency - in men and we discuss both well-established and supposed estr...

journal_title：Molecular and cellular endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Baraldi E,Faustini-Fustini M,Granata AR,Carani C

更新日期：2001-06-10 00:00:00

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

journal_title：Molecular and cellular endocrinology

authors： Domené S,Domené HM

更新日期：2020-12-01 00:00:00

abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

更新日期：2016-01-05 00:00:00

abstract：:Relaxin is a peptide hormone which consists of two polypeptide chains that are synthesized as a B-chain/C-peptide/A-chain precursor. We have used the polymerase chain reaction (PCR) to isolate and clone a relaxin-like cDNA from sheep placental RNA. This cDNA and two sheep genomic clones were characterised by nucleotid...

journal_title：Molecular and cellular endocrinology

authors： Roche PJ,Crawford RJ,Tregear GW

更新日期：1993-02-01 00:00:00

abstract：:The expression of Kiss1 in the anteroventral periventricular nucleus (AVPV) and its product, metastin/kisspeptin, show a circadian pattern with a peak in the evening, which shows a strong phase relationship with the time of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) surge in rodents. Here we re...

journal_title：Molecular and cellular endocrinology

authors： Xu Z,Kaga S,Tsubomizu J,Fujisaki J,Mochiduki A,Sakai T,Tsukamura H,Maeda K,Inoue K,Adachi AA

更新日期：2011-06-06 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These ligand-activated transcription factors are implicated in the regulation of lipid metabolism and adipocyte differentiation and in the regulation of anti-inflammatory processes. In order to bind to DNA ...

journal_title：Molecular and cellular endocrinology

authors： Gorla-Bajszczak A,Juge-Aubry C,Pernin A,Burger AG,Meier CA

更新日期：1999-01-25 00:00:00

abstract：:The cDNA encoding the bovine activin type II receptor has been cloned by reverse transcription-polymerase chain reaction (RT-PCR) amplification of a bovine testicular RNA preparation. Sequence comparisons of the bovine activin type II receptor with its human, mouse and rat homologues show strong evolutionary conservat...

journal_title：Molecular and cellular endocrinology

authors： Ethier JF,Houde A,Lussier JG,Silversides DW

更新日期：1994-12-01 00:00:00

abstract：:The rapid effects of steroids on spermatozoa have been demonstrated for the first time two decades ago. Progesterone (P), which is present throughout the female genital tract with peaks of levels in the cumulus matrix surrounding the oocyte, stimulates several sperm functions, including hyperactivation and acrosome re...

journal_title：Molecular and cellular endocrinology

authors： Baldi E,Luconi M,Muratori M,Marchiani S,Tamburrino L,Forti G

更新日期：2009-09-24 00:00:00

abstract：:Stimulation of insulin secretion is accompanied by changes in the phosphorylation state of several islet polypeptides. Protein (de)phosphorylation is mediated by the action of protein kinases and phosphoprotein phosphatases. In this study we have investigated expression of phospho-serine/threonine phosphatases (PPs) i...

journal_title：Molecular and cellular endocrinology

authors： Murphy LI,Jones PM

更新日期：1996-03-25 00:00:00

abstract：:It has recently been reported that phenol red, a pH indicator present in most tissue culture media, is a weak estrogen that can stimulate some estrogen-sensitive cells. However, the relative impact of phenol red on various cell lines is controversial. We examined the effect of phenol red on several estrogen-responsive...

journal_title：Molecular and cellular endocrinology

authors： Welshons WV,Wolf MF,Murphy CS,Jordan VC

更新日期：1988-06-01 00:00:00

abstract：:cAMP signalling plays a key role in the normal physiology of the pituitary gland, regulating cellular growth and proliferation, hormone production and release. Deregulation of the cAMP signalling pathway has been reported to be a common occurrence in pituitary tumorigenesis. Several mechanisms have been implicated inc...

journal_title：Molecular and cellular endocrinology

authors： Formosa R,Vassallo J

更新日期：2014-07-05 00:00:00

abstract：:The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. Two forms of PRL-R, a high and a low molecular weight form, were revealed by studies of covalent crosslinkin...

journal_title：Molecular and cellular endocrinology

authors： Weiss-Messer E,Ber R,Amit T,Barkey RJ

更新日期：1998-08-25 00:00:00

abstract：:A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R). Tetrapod and teleost MC2R orth...

journal_title：Molecular and cellular endocrinology

authors： Dores RM,Garcia Y

更新日期：2015-06-15 00:00:00

abstract：:In Manduca sexta, basal and PTTH-stimulated secretion of ecdysteroids by prothoracic glands in vitro increases from days 1 to 4 of the fifth larval stage. Glandular content of cAMP-dependent protein kinase was analyzed to determine if the enzyme changes in concert with increased secretory response. Photoaffinity label...

journal_title：Molecular and cellular endocrinology

authors： Smith WA,Varghese AH,Lou KJ

更新日期：1993-01-01 00:00:00

abstract：:Cell-cell interactions are crucial role for the proper functioning of endocrine glands. We recently demonstrated that interactions of chromaffin and cortical cells are important for adrenocortical steroidogenesis. However, the molecular mechanisms have not been elucidated and it is unclear if this involves acute and/o...

journal_title：Molecular and cellular endocrinology

authors： Haidan A,Bornstein SR,Liu Z,Walsh LP,Stocco DM,Ehrhart-Bornstein M

更新日期：2000-07-25 00:00:00

abstract：:Prostaglandin A1 (PGA1) increases heat shock element (HSE)-mediated transcription, thereby enhancing expression of HSE-bearing genes, including heat shock proteins. Because we recently found functional HSEs in the human and rodent c-fos promoters, we hypothesized that PGA1 might increase c-fos expression through the H...

journal_title：Molecular and cellular endocrinology

authors： Ishikawa T,Sekine N,Hata K,Igarashi T,Fujita T

更新日期：2000-06-01 00:00:00

abstract：:Men have had a substantially higher risk of developing bladder cancer than women. This has prompted research on androgen-mediated androgen receptor (AR) signaling in urothelial cancer. Indeed, increasing preclinical evidence indicates that AR activation correlates with the promotion of urothelial carcinogenesis and tu...

journal_title：Molecular and cellular endocrinology

authors： Inoue S,Mizushima T,Miyamoto H

更新日期：2018-04-15 00:00:00

abstract：:The role of protein kinase C (PKC) isoforms (PKCs) in GnRH-stimulated MAPK [ERK1/2, JNK1/2 and p38) phosphorylation was examined in gonadotrope derived cells. GnRH induced a protracted activation of ERK1/2 and a slower and more transient activation of JNK1/2 and p38MAPK. Gonadotropes express conventional PKCα and PKCβ...

journal_title：Molecular and cellular endocrinology

authors： Mugami S,Dobkin-Bekman M,Rahamim-Ben Navi L,Naor Z

更新日期：2018-03-05 00:00:00

abstract：:The effects of tamoxifen (Tam) and its 4-hydroxylated metabolite (OH-Tam) on the growth of two human breast cancer cell lines ( MCF7 and BT20 ) were evaluated by fluorometric DNA assay. The effects of the antiestrogens were dependent upon their concentrations and the nature of the cells. At concentrations below 4 micr...

journal_title：Molecular and cellular endocrinology

authors： Bardon S,Vignon F,Derocq D,Rochefort H

更新日期：1984-05-01 00:00:00

abstract：:A Chinese family with autosomal recessive pituitary dwarfism was identified and the proband was evaluated by MRI and hormonal analysis, which revealed pituitary dwarfism with a complete growth hormone deficiency. MRI showed a pituitary gland with a small anterior pituitary of 2.2mm and evidence of hypoplastic pituitar...

journal_title：Molecular and cellular endocrinology

authors： Wang Q,Diao Y,Xu Z,Li X,Luo XP,Xu H,Ouyang P,Liu M,Hu Z,Wang QK,Liu JY

更新日期：2009-12-10 00:00:00

abstract：:Transthyretin (TTR) is a plasma thyroid hormone (TH) binder that emerged from an ancient hydroxyisourate hydrolase by gene duplication. To know how an ancient TTR had high affinity for THs, molecular and TH binding properties of lamprey TTRs were investigated. In adult serum, the lipoprotein LAL was a major T3 binder ...

journal_title：Molecular and cellular endocrinology

authors： Kasai K,Nishiyama N,Yamauchi K

更新日期：2018-10-15 00:00:00

abstract：:The intranuclear locations at which rat uterine estrogen receptors interact with chromatin have been probed using digestions performed with DNAase I and micrococcal nuclease. Exposure to nuclease has been controlled to effect limited to extensive digestion of nuclear DNA under conditions which maintain the integrity o...

journal_title：Molecular and cellular endocrinology

authors： Pavlik EJ,Katzenellenbogen BS

更新日期：1982-04-01 00:00:00

abstract：:Follistatin (FS) is well characterized as an activin-binding protein. Recently, a novel follistatin-like protein called follistatin-related gene (FLRG) that has a similar domain organization to that of follistatin has been identified. Like follistatins, FLRG binds activins and bone morphogenetic proteins (BMPs). To st...

journal_title：Molecular and cellular endocrinology

authors： Nakatani M,Yamakawa N,Matsuzaki T,Shimasaki S,Sugino H,Tsuchida K

更新日期：2002-03-28 00:00:00

abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

journal_title：Molecular and cellular endocrinology

authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

更新日期：2012-10-15 00:00:00

abstract：:In this study we have investigated the protein phosphorylation pattern in the membrane fraction prepared from bovine luteal cells. The phosphorylation reaction was carried out in vitro, under defined conditions, using either [gamma-32P]ATP or [gamma-35S]ATP as the phosphate donor. The results obtained show that [gamma...

journal_title：Molecular and cellular endocrinology

authors： Budnik LT,Mukhopadhyay AK

更新日期：1990-03-05 00:00:00

abstract：:For investigation of the mechanism and pathogenesis of Graves' disease, availability of a large amount of functional human thyrotropin receptor (TSHR) capable of recognition by Graves' autoantibodies is essential. Many attempts have been made to produce the extracellular domain of TSH receptor (TSHRE) in a baculovirus...

journal_title：Molecular and cellular endocrinology

authors： Park JY,Lee J,Cho BY,Chae CB

更新日期：1999-01-25 00:00:00