当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Nongenomic activation of spermatozoa by steroid hormones: facts and fictions.

Nongenomic activation of spermatozoa by steroid hormones: facts and fictions.

Abstract：

:The rapid effects of steroids on spermatozoa have been demonstrated for the first time two decades ago. Progesterone (P), which is present throughout the female genital tract with peaks of levels in the cumulus matrix surrounding the oocyte, stimulates several sperm functions, including hyperactivation and acrosome reaction. These effects are mediated by an extranuclear pathway, as P stimulates an influx of calcium, the tyrosine phosphorylation of sperm proteins and other signalling cascades in a rapid manner. Whether these effects are receptor mediated and which receptors mediate these effects are still a matter of discussion despite all the efforts of the scientific community aimed at identifying them during the last 20 years. Although responsiveness to P is related to sperm fertilizing ability, the physiological role of P during the process of fertilization is discussed, and recent evidence points for a role of the steroid as a chemotactic agent for sperm. A similar situation applies for estrogens (E), which have been shown to induce direct effects on sperm by an extranuclear pathway. In particular, E appear to decrease acrosome reaction in response to P, exerting a role in ensuring an appropriate timing for sperm exocytosis during the process of fertilization.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Baldi E,Luconi M,Muratori M,Marchiani S,Tamburrino L,Forti G

doi

10.1016/j.mce.2009.02.006

subject

Has Abstract

pub_date

2009-09-24 00:00:00

pages

39-46

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(09)00131-2

journal_volume

308

pub_type

杂志文章,评审

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Immunocytochemical localization of inhibin in rat and human reproductive tissues.

    abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90162-6

    authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

    更新日期：1987-12-01 00:00:00

  • CYP51--the omnipotent P450.

    abstract：:Sterol 14 alpha-demethylase (CYP51) is the single cytochrome P450 (CYP) required for sterol biosynthesis in different phyla, and it is the most widely distributed P450 gene family being found in all biological kingdoms. It catalyzes the first step following cyclization in sterol biosynthesis such as removal of the 14 ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2003.11.016

    authors： Lepesheva GI,Waterman MR

    更新日期：2004-02-27 00:00:00

  • Physicochemical analysis of glucocorticoid receptor in the immature pituitary gland: evidence for lability and aggregation of the heat-activated form.

    abstract：:The present study was aimed at characterizing the deficiency of the glucocorticoid-receptor system in the immature pituitary gland of neonatal rats. Under conditions of both constant protein and DNA concentrations, [3H]dexamethasone binding to nuclei was significantly lower in the immature, compared with the mature, g...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90038-7

    authors： Sakly M,Koch B

    更新日期：1982-09-01 00:00:00

  • Mutational analysis of rare subtypes of congenital adrenal hyperplasia in a highly inbred population.

    abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2017.08.022

    authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

    更新日期：2018-02-05 00:00:00

  • Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.

    abstract：:Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.11.025

    authors： Papaconstantinou J

    更新日期：2009-02-05 00:00:00

  • Deletion of lysine 13 alters the structure and function of parathyroid hormone.

    abstract：:A peptide of unknown structure was found as a side product in a commercial preparation of the 1-34 fragment of bovine parathyroid hormone (PTH). CNBr cleavage and amino acid analysis showed that this peptide is the des-lys-13 form of 1-34 bovine PTH. The peptide thus represents a deletion mutant of PTH and structure-f...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90037-2

    authors： Zull JE,Smith LM,Chuang J,Jentoft J

    更新日期：1987-06-01 00:00:00

  • Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

    abstract：:Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.06.014

    authors： Villa-Osaba A,Gahete MD,Cordoba-Chacon J,de Lecea L,Castaño JP,Luque RM

    更新日期：2016-10-15 00:00:00

  • Structural analyses of sex hormone-binding globulin reveal novel ligands and function.

    abstract：:Plasma sex hormone-binding globulin (SHBG) regulates the access of androgens and estrogens to their target tissues and cell types. An SHBG homologue, known as the androgen-binding protein, is expressed in Sertoli cells of many mammalians, but testicular expression of human SHBG is restricted to germ cells. The primary...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2009.09.005

    authors： Avvakumov GV,Cherkasov A,Muller YA,Hammond GL

    更新日期：2010-03-05 00:00:00

  • In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland.

    abstract：:Cell-based studies previously showed that the ATP-binding cassette transporter A1 (ABCA1) transfers cholesterol across mammary epithelial cells (MEC). Data for phospholipid transport are lacking, and it is unclear from which cellular source the transported cholesterol stems, whether this transport activates signaling ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.10.016

    authors： Ontsouka CE,Huang X,Aliyev E,Albrecht C

    更新日期：2017-01-05 00:00:00

  • The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer.

    abstract：:17Beta-hydroxysteroid dehydrogenase Type 1 (17beta-HSD1) has a pivotal role in regulating the synthesis of oestradiol (E2) within breast tumours. In whole body studies in postmenopausal women with breast cancer the conversion of oestrone (E1) to E2 (4.4+/-1.1%) was much lower than the inactivation of E2 to E1 (17.3+/-...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.12.003

    authors： Purohit A,Tutill HJ,Day JM,Chander SK,Lawrence HR,Allan GM,Fischer DS,Vicker N,Newman SP,Potter BV,Reed MJ

    更新日期：2006-03-27 00:00:00

  • Partial characterization of somatomedin C-like immunoreactivity secreted by breast cancer cells in vitro.

    abstract：:The in vitro secretion of immunoreactive somatomedin C/insulin-like growth factor I (IR Sm-C/IGF-I) by two human breast cancer cell lines, MCF-7 and EVSA-T has been studied. IR Sm-C/IGF-I concentration showed a linear increase in serum-free culture media over 72 h of incubation for both cell lines, and a close correla...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90155-9

    authors： Minuto F,Del Monte P,Barreca A,Nicolin A,Giordano G

    更新日期：1987-12-01 00:00:00

  • Fourier analysis of differential light scattering for the quantitation of FSH response associated with structural changes in immortalized granulosa cells.

    abstract：:We have established granulosa cell lines which express constitutively the rat FSH receptors by cotransfection of primary granulosa cells obtained from preovulatory follicles with SV40 DNA, Ha-ras oncogene and a plasmid expressing FSH receptors. These cells respond specifically to ovine and human FSH by cell rounding, ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03774-4

    authors： Schiffer Z,Keren-Tal I,Deutsch M,Dantes A,Aharoni D,Weinerb A,Tirosh R,Amsterdam A

    更新日期：1996-04-19 00:00:00

  • MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity.

    abstract：:Visceral obesity is an independent risk factor for metabolic syndrome, and abnormal fat accumulation is linked to increases in the number and size of adipocytes. MiR-146b was a miRNA highly expressed in mature adipocytes while very lowly expressed in human mesenchymal stem cells (hMSCs) and human visceral preadipocyte...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.05.022

    authors： Chen L,Dai YM,Ji CB,Yang L,Shi CM,Xu GF,Pang LX,Huang FY,Zhang CM,Guo XR

    更新日期：2014-08-05 00:00:00

  • Reproductive function after treatment of malignant germ cell ovarian tumors.

    abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(03)00072-8

    authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

    更新日期：2003-04-28 00:00:00

  • KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort.

    abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.03.007

    authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

    更新日期：2016-05-15 00:00:00

  • Effect of transforming growth factor-beta 1 on the insulin-like growth factor system in cultured porcine Leydig cells.

    abstract：:Using as a model system, primary cultures of porcine Leydig cells, we have shown that transforming growth factor-beta 1 (TGF-beta 1) (2 ng/ml, 72 h) antagonizes the stimulatory action of insulin-like growth factor-I (IGF-I) on luteinizing hormone (LH/hCG) receptors. We therefore investigated the action of TGF-beta 1 o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(94)90015-9

    authors： Besset V,Collette J,Chauvin MA,Franchimont P,Benahmed M

    更新日期：1994-03-01 00:00:00

  • Pituitary-testicular function in immature rats after treatment with GnRH antagonist, GnRH antiserum and bromocriptine.

    abstract：:The effects of a GnRH antagonist analogue (N-acetyl-Ala1,D-p-Cl-Phe2,D-Trp3,6-GnRH, Ant.) and a GnRH antiserum (A/S) on the development of pituitary-testicular function were studied in immature (23/24-31/32-day-old) rats. In another experiment the Ant. treatment was combined with bromocriptine (BR)-induced hypoprolact...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(84)90065-0

    authors： Huhtaniemi IT,Stewart JM,Channabasavaiah K,Fraser HM,Clayton RN

    更新日期：1984-02-01 00:00:00

  • Indication of different lactogen and somatogen binding sites in the human growth hormone molecule as probed with monoclonal antibodies.

    abstract：:The relationship between the structure of human growth hormone (hGH) and the hormone-receptor interaction has been investigated using as probes monoclonal antibodies (Mabs) to hGH of defined epitope specificity profile. Seven high affinity Mabs were studied for their ability (i) to inhibit the binding of 125I-hGH to N...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90230-x

    authors： Strasburger CJ,Binder L,Elberg G,Cohen-Chapnik N,Kohen F,Gertler A

    更新日期：1989-11-01 00:00:00

  • Expression of porcine pro-opiomelanocortin cDNA in an established fibroblastic cell line: constitutive secretion of the precursor without proteolytic processing.

    abstract：:Pro-opiomelanocortin (POMC) is the common precursor of several pituitary hormones including alpha-melanotropic hormone, adrenocorticotropic hormone, beta-lipotropin and beta-endorphin. The porcine POMC cDNA was inserted downstream from the late promoter of an SV40-derived expression vector and co-transfected in NIH 3T...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90051-2

    authors： Zollinger L,Noël G,Des Parois L,Sales V,Crine P,Boileau G

    更新日期：1988-07-01 00:00:00

  • Autoregulation of androgen receptor in rat ventral prostate: involvement of c-fos as a negative regulator.

    abstract：:Recent work from our laboratory has focused on elucidating the mechanism of androgen regulation of the androgen receptor (AR). We have demonstrated that testosterone increases AR protein and binding within 1 h in the ventral prostate of adult rats castrated for 24 h. Cycloheximide administered with testosterone reduce...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(96)03939-1

    authors： Mora GR,Mahesh VB

    更新日期：1996-11-29 00:00:00

  • Single-column purification and bio-characterization of recombinant human parathyroid hormone-related protein (1-139).

    abstract：:Recombinant human parathyroid hormone-related protein (hPTHrP) (1-139) was expressed using the IMPACT T7 (intein-mediated purification with an affinity chitin-binding tag) system, allowing purification of free recombinant peptide in a single chromatographic step. This system utilizes an intein, which is a protein spli...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00323-3

    authors： Wu C,Seitz PK,Falzon M

    更新日期：2000-12-22 00:00:00

  • Compartmentalization of luteinizing hormone pools: dynamics of gonadotropin releasing hormone action in superfused pituitary cells.

    abstract：:Cultured rat anterior pituitary cells were continuously perfused with medium 199, and exposed to short (5 min), intermediate (30 min), or long (6 h) pulses of a maximally effective concentration of gonadotropin-releasing hormone (GnRH). Assay of the effluent by radioimmunoassay and interstitial-cell bioassay revealed ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90110-1

    authors： Naor Z,Katikineni M,Loumaye E,Vela AG,Dufau ML,Catt KJ

    更新日期：1982-07-01 00:00:00

  • Multifunctionality of human 17beta-hydroxysteroid dehydrogenases.

    abstract：:17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. Durin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.11.031

    authors： Moeller G,Adamski J

    更新日期：2006-03-27 00:00:00

  • Characterization of two forms of cyclic 3', 5'-adenosine monophosphate-dependent protein kinase in rat testicular interstitial cells.

    abstract：:The adenosine 3', 5'-cyclic monophosphate (cyclic AMP)-dependent protein phosphokinase of rat interstitial cells was characterized by ion-exchange chromatography and sucrose density gradient centrifugation. The 0.2 M NaCl fraction from DEAE-Sephadex showed a small 2.9-S peak of basal enzyme activity, and a large 6.5-S...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(76)90074-5

    authors： Podesta EJ,Dufau ML,Catt KJ

    更新日期：1976-06-01 00:00:00

  • Action of hydrocortisone at a translational level in the rat liver.

    abstract：:Administration of hydrocortisone to adrenalectomised rats elevated levels of both free and membrane-bound polysomes in liver and led to marked shifts in their sedimentation profiles in favour of heavier polysomes. The rate of nascent polypeptide formation was also found to be enhanced in response to the hormone but th...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(76)90038-1

    authors： Kulkarni SB,Netrawali MS,Pradhan DS,Sreenivasan A

    更新日期：1976-02-01 00:00:00

  • The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells.

    abstract：:Calbindin-D9k (CaBP-9k) is a high affinity calcium binding protein that is highly expressed in the duodenum, kidney, uterus, and pituitary glands. Previous studies have shown that CaBP-9k expression is regulated by several steroid hormones, such as 1,25-dihydroxyvitamin D3, glucocorticoids, 17beta-estradiol (E2), and ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.07.009

    authors： Lee GS,Choi KC,Han HJ,Jeung EB

    更新日期：2007-10-15 00:00:00

  • Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells.

    abstract：:Corticotropin-releasing factor (CRF) receptor type 1 (CRF(1) receptor) mRNA levels are down-regulated by CRF via the cyclic AMP-protein kinase A (PKA) pathway. In this study, we focused on the involvement of both the mitogen-activated protein (MAP) kinase pathway and PKA in this regulation. Real-time PCR (RT-PCR) reve...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.09.010

    authors： Moriyama T,Kageyama K,Kasagi Y,Iwasaki Y,Nigawara T,Sakihara S,Suda T

    更新日期：2005-11-24 00:00:00

  • Progesterone modulation of gonadotropin secretion by dispersed rat pituitary cells in culture. II. Intracellular metabolism and progestin receptors.

    abstract：:Dispersed, estradiol (E2)-treated, rat pituitary cell cultures were used to examine the intracellular processing of progesterone (P) associated with its modulation of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretion. Enhancement and suppression of LH release was only observed with ac...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90181-7

    authors： Krey LC,Kamel F,MacLusky NJ

    更新日期：1990-01-22 00:00:00

  • Expression of an estrogen receptor alpha variant protein in cell lines and tumors.

    abstract：:Human estrogen receptor alpha (ER) mRNA is a mixture of wild type and alternatively spliced variants. Many studies have examined the potential of ER mRNA profiles to serve as diagnostic/prognostic cancer biomarkers, but only a few have attempted to correlate ER mRNA profiles with protein expression. Representative ER ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00194-5

    authors： Fasco MJ,Keyomarsi K,Arcaro KF,Gierthy JF

    更新日期：2000-04-25 00:00:00

  • Autoradiographic localization of beta-adrenergic receptors in rat oviduct.

    abstract：:Catecholamines are known to have an inhibitory effect on oviductal smooth musculature by changing the adrenergic receptors activity. In order to further investigate the role of epinephrine and/or norepinephrine in oviduct, the distribution of beta-adrenergic receptors has been studied in the rat oviduct, using in vitr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90123-2

    authors： Tolszczuk M,Pelletier G

    更新日期：1988-11-01 00:00:00