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Autoradiographic localization of beta-adrenergic receptors in rat oviduct.

Abstract：

:Catecholamines are known to have an inhibitory effect on oviductal smooth musculature by changing the adrenergic receptors activity. In order to further investigate the role of epinephrine and/or norepinephrine in oviduct, the distribution of beta-adrenergic receptors has been studied in the rat oviduct, using in vitro autoradiography and [125I]cyanopindolol (CYP), as radioligand. The specificity of the labelling and the characterization of receptor subtypes in different cell types was achieved by displacement of radioligand with increasing concentrations of zinterol, a beta-adrenergic agonist with preferential affinity for the beta 2-adrenoreceptor subtype and practolol, a beta-adrenergic antagonist that binds preferentially to beta 1-subtype. Quantitative estimation of ligand binding was achieved by densitometry. It was shown that the vast majority of beta-receptors were of the beta 2-subtype and were found in smooth muscle layers as well as in the epithelium. The latter localization suggests a role for epinephrine and/or norepinephrine on the oviductal epithelium.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Tolszczuk M,Pelletier G

doi

10.1016/0303-7207(88)90123-2

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

95-9

issue

1

eissn

0303-7207

issn

1872-8057

pii

0303-7207(88)90123-2

journal_volume

60

pub_type

杂志文章

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