Role of the androgen receptor in urothelial cancer.

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00

abstract：:The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR g...

journal_title：Molecular and cellular endocrinology

authors： Henrohn D,Le Grevés P,Nyberg F

更新日期：1997-12-12 00:00:00

abstract：:Urine based gonadotropin assays provide a practical means of analyzing hormone secretion patterns. While research protocols have revealed pulsatile patterns of gonadotropins such as LH in the blood, these assays are of limited clinical use since daily venipuncture sampling is not feasible outside of a research environ...

journal_title：Molecular and cellular endocrinology

authors： Birken S,McChesney R,Yershova O,Gaughan J,Pettersson K,Rechenberg G,Wu CH,Taliadouros G

更新日期：2007-01-02 00:00:00

abstract：:Nitroblue tetrazolium (NBT) has been widely used to demonstrate redox systems, particularly in phagocytizing polymorphonuclear leukocytes. Based on the striking similarities between redox metabolism in leukocytes and in the thyroid, we studied NBT reduction by microscopic techniques and NBT effects in thyroid metaboli...

journal_title：Molecular and cellular endocrinology

authors： van Sande J,Ketelbant-Balasse P,Schell-Frederick E,Dumont JE

更新日期：1982-04-01 00:00:00

abstract：:Inflammation causes male hypogonadism. Several inflammatory cytokines, including interleukin 6 (IL-6), are released into the blood and may suppress Leydig cell development. The objective of the present study was to investigate whether IL-6 affected the proliferation and differentiation of rat stem Leydig cells. Leydig...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Chen L,Xie L,Li L,Li X,Li H,Liu J,Chen X,Mao B,Song T,Lian Q,Ge RS

更新日期：2018-09-05 00:00:00

abstract：:When measured in vitro using human placental microsomal preparations, the aromatization of 16alpha-hydroxytestosterone to estriol and androstenedione to estrone and estradiol proceeds at almost identical initial rates. Important differences between 16alpha-hydroxytestosterone and adrostenedione aromatization are evide...

journal_title：Molecular and cellular endocrinology

authors： Canick JA,Ryan KJ

更新日期：1976-12-01 00:00:00

abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

更新日期：2016-01-05 00:00:00

abstract：:Signaling mechanisms for Blaberus discoidalis hypertrehalosemic hormone (Bld-HrTH)-dependent glycogen phosphorylase activation were investigated in vitro using fat body of the tropical cockroach, B. discoidalis. Brief treatment of fat bodies with Bld-HrTH in the absence of extracellular Ca2+ showed a significant activ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Keeley LL

更新日期：1996-02-05 00:00:00

abstract：:The role of protein kinase C (PKC) isoforms (PKCs) in GnRH-stimulated MAPK [ERK1/2, JNK1/2 and p38) phosphorylation was examined in gonadotrope derived cells. GnRH induced a protracted activation of ERK1/2 and a slower and more transient activation of JNK1/2 and p38MAPK. Gonadotropes express conventional PKCα and PKCβ...

journal_title：Molecular and cellular endocrinology

authors： Mugami S,Dobkin-Bekman M,Rahamim-Ben Navi L,Naor Z

更新日期：2018-03-05 00:00:00

abstract：:Glucose transport activity ([3H]D-glucose uptake) in liver sinusoidal membrane vesicles (SMVs) from hyperthyroid rats was significantly higher than that from euthyroid controls (2.1-times increase in V(max) with K(m) unchanged at approximately 18 mM), associated with increased GLUT2 expression. In contrast, glucose tr...

journal_title：Molecular and cellular endocrinology

authors： Kemp HF,Hundal HS,Taylor PM

更新日期：1997-04-04 00:00:00

abstract：:Fibroblasts from three patients with vitamin D-dependency rickets type II were used to study mutations in the 1,25-dihydroxyvitamin D3 receptor responsible for this hereditary disease. Normal human fibroblasts contain 43 +/- 13 fmol receptor/mg protein as determined by immunoradiometric assay and 22 +/- 3 fmol/mg by l...

journal_title：Molecular and cellular endocrinology

authors： Wiese RJ,Goto H,Prahl JM,Marx SJ,Thomas M,al-Aqeel A,DeLuca HF

更新日期：1993-01-01 00:00:00

abstract：:In the characterization of newly identified proteins, subcellular localization studies can provide important hints to the proteins' metabolic functions. Depending on the biochemical task of an enzyme, certain subcellular environmental conditions as pH or availability of cofactors and substrates have to be fulfilled. C...

journal_title：Molecular and cellular endocrinology

authors： Keller B,Meier M,Adamski J

更新日期：2009-03-25 00:00:00

abstract：:We have examined the relationship between extracellular Ca2+, cytosolic free Ca2+ and insulin release in the clonal beta-cell line HIT-T15. Glucose-stimulated insulin release was dependent on the extracellular Ca2+ concentration in a dose-related manner; the threshold medium Ca2+ concentration for glucose-stimulated i...

journal_title：Molecular and cellular endocrinology

authors： Hughes SJ,Chalk JG,Ashcroft SJ

更新日期：1989-08-01 00:00:00

abstract：:The angiotensin II (AngII) type 1 (AT(1)) receptor is a seven-transmembrane G protein-coupled receptor, and is involved in regulating the physiological and pathological process of the cardiovascular system. Systemically and locally generated AngII has agonistic action on AT(1) receptor, but recent studies have demonst...

journal_title：Molecular and cellular endocrinology

authors： Akazawa H,Yasuda N,Komuro I

更新日期：2009-04-29 00:00:00

abstract：:Studies were conducted in vitro and in vivo to determine whether or not inhibin affects the transcription rate of the gene for the beta subunit of follicle stimulating hormone (FSH beta). Pituitary cells in primary culture were incubated with 0-3000 milli-units/ml inhibin; a dose-related decrement in mRNA was obtained...

journal_title：Molecular and cellular endocrinology

authors： Clarke IJ,Rao A,Fallest PC,Shupnik MA

更新日期：1993-02-01 00:00:00

abstract：:After i.m. injection of [3H]butyrobetaine into rats, the accumulation of carnitine into the epididymis, prostate gland, seminal vesicles, testis and heart was studied. The concentration of radiolabeled carnitine into the cauda epididymis increased linearly with time up to 72 h after the injection of the precursor, whi...

journal_title：Molecular and cellular endocrinology

authors： Bohmer T,Hansson V

更新日期：1975-08-01 00:00:00

abstract：:A major change in thyroid setpoint regulation occurs in various clinical conditions such as critical illness and psychiatric disorders. As a first step towards identifying determinants of these setpoint changes, we have studied the distribution and expression of thyroid hormone receptor (TR) isoforms, type 2 and type ...

journal_title：Molecular and cellular endocrinology

authors： Fliers E,Unmehopa UA,Alkemade A

更新日期：2006-06-07 00:00:00

abstract：:PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. ...

journal_title：Molecular and cellular endocrinology

authors： Athanason MG,Ratliff WA,Chaput D,MarElia CB,Kuehl MN,Stevens SM Jr,Burkhardt BR

更新日期：2016-11-15 00:00:00

abstract：:The binding of triiodothyronine (T3) to tadpole liver, intestine, and tail fin nuclei was consistent with a single class of binding sites. The KD for the binding of T3 to isolated nuclei from the liver (1.02 nM), intestine (1.40 nM), and tail fin (0.831 nM) nuclei were not significantly different. The number of bindin...

journal_title：Molecular and cellular endocrinology

authors： Jaffe RC

更新日期：1987-07-01 00:00:00

abstract：:While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

journal_title：Molecular and cellular endocrinology

authors： Thoennes SR,Tate PL,Price TM,Kilgore MW

更新日期：2000-02-25 00:00:00

abstract：:Human breast cancer cells selected for multidrug resistance frequently overexpress ligands and receptors in the epidermal growth factor (EGF) receptor family. To determine whether this overexpression contributes to the drug resistant phenotype, EGF receptor transfected ZR75B human breast cancer cells were examined. Tw...

journal_title：Molecular and cellular endocrinology

authors： Dickstein BM,Wosikowski K,Bates SE

更新日期：1995-04-28 00:00:00

abstract：:During critical periods of development, hypothyroidism causes abnormalities of the central nervous system such as incomplete maturation of neuronal and glial cells, reduction in synaptic densities and myelin deficits. In this study expression of development regulated genes, ie transcription of beta-actin, sema 3F, CRM...

journal_title：Molecular and cellular endocrinology

authors： Wong CC,Leung MS

更新日期：2001-11-26 00:00:00

abstract：:While the transcriptional effects of glucocorticoid hormone manipulation on the pituitary pro-opiomelanocortin (POMC) gene have been documented, it is not yet clear whether glucocorticoids activate additional post-transcriptional mechanisms to regulate POMC gene expression. We have used RNA probes that span exon/intro...

journal_title：Molecular and cellular endocrinology

authors： Autelitano DJ,Blum M,Roberts JL

更新日期：1989-10-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a persistent pollutant worldwide and even found in human cord blood and breast milk. Some animal studies have reported that PFOA causes developmental toxicity such as fetal weight loss, but the mechanism is still unclear. This study focused on developmental toxicity of PFOA, particular...

journal_title：Molecular and cellular endocrinology

authors： Suh CH,Cho NK,Lee CK,Lee CH,Kim DH,Kim JH,Son BC,Lee JT

更新日期：2011-04-30 00:00:00

abstract：:The red-spotted grouper, Epinephelus akaara, is a protogynous hermaphroditic fish that shows the characteristic of natural sex change. In this study, 2-year-old female groupers were successfully reversed to functional males by oral administration of 17alpha-methyltestosterone (MT) for 42 days. The protein inhibitor of...

journal_title：Molecular and cellular endocrinology

authors： Li SW,Long ZF,Du J,Liu SG,Wen JJ

更新日期：2009-10-15 00:00:00

abstract：:Carbamylcholine and acetylcholine through a muscarinic type of receptor, KCl, ionophore A-23187 and NaF increased cyclic GMP accumulation in dog-thyroid slices. These effects were abolished in calcium-depleted slices, which findings confirm that Ca2+ is required for cyclic GMP accumulation. All these agents depressed ...

journal_title：Molecular and cellular endocrinology

authors： van Sande J,Decoster C,Dumont JE

更新日期：1979-04-01 00:00:00

abstract：:Phospholipase C (PHL-C) activity determined in homogenates of fat cells treated with physiological concentrations of insulin showed a 2-3-fold increase as compared to controls in the absence of insulin. The changes of PHL-C and pyruvate dehydrogenase (PDH) activity which was measured concomitantly exhibited very simil...

journal_title：Molecular and cellular endocrinology

authors： Koepfer-Hobelsberger B,Wieland OH

更新日期：1984-06-01 00:00:00

abstract：:The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have...

journal_title：Molecular and cellular endocrinology

authors： Stocco DM,Clark BJ,Reinhart AJ,Williams SC,Dyson M,Dassi B,Walsh LP,Manna PR,Wang XJ,Zeleznik AJ,Orly J

更新日期：2001-05-25 00:00:00

abstract：:When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accum...

journal_title：Molecular and cellular endocrinology

authors： Verhoeven G,Cailleau J,de Moor P

更新日期：1980-11-01 00:00:00

abstract：:Recently, the structures of two forms of inhibin present in human follicular fluid were elucidated from the corresponding cDNA sequences. Using specific antisera generated against the alpha-chain common to both forms, we have examined the cellular localization of inhibin in the male and female rat gonads and in human ...

journal_title：Molecular and cellular endocrinology

authors： Merchenthaler I,Culler MD,Petrusz P,Negro-Vilar A

更新日期：1987-12-01 00:00:00